Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference

Intergenic transcription is a common feature of eukaryotic genomes and performs important and diverse cellular functions. Here, we investigate the iab-8 ncRNA from the Drosophila Bithorax Complex and show that this RNA is able to repress the transcription of genes located at its 3' end by a seq...

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Veröffentlicht in:	PLoS genetics 2021-11, Vol.17 (11), p.e1009843-e1009843
Hauptverfasser:	Castro Alvarez, Javier J, Revel, Maxime, Carrasco, Judit, Cléard, Fabienne, Pauli, Daniel, Hilgers, Valérie, Karch, François, Maeda, Robert K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Binding proteins Biology and life sciences Clustered Regularly Interspaced Short Palindromic Repeats CRISPR Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins - genetics ELAV Proteins - genetics Embryos Epidermis Gene expression Genes, Homeobox Genes, Reporter Genetic regulation Genomes HOX gene Hybridization Influence Medicine and Health Sciences MicroRNAs MicroRNAs - genetics Mutation Non-coding RNA Nuclear Proteins - genetics Nucleotide sequence Proteins Research and Analysis Methods Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA-binding protein RNA-mediated interference Sequence Deletion Transcription Transcription Factors - genetics Transcription, Genetic
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