Impacts of fungal entomopathogens on survival and immune responses of Aedes albopictus and Culex pipiens mosquitoes in the context of native Wolbachia infections
Microbial control of mosquitoes via the use of symbiotic or pathogenic microbes, such as Wolbachia and entomopathogenic fungi, are promising alternatives to synthetic insecticides to tackle the rapid increase in insecticide resistance and vector-borne disease outbreaks. This study evaluated the susc...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2021-11, Vol.15 (11), p.e0009984-e0009984 |
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| creator | Ramirez, Jose L Schumacher, Molly K Ower, Geoff Palmquist, Debra E Juliano, Steven A |
| description | Microbial control of mosquitoes via the use of symbiotic or pathogenic microbes, such as Wolbachia and entomopathogenic fungi, are promising alternatives to synthetic insecticides to tackle the rapid increase in insecticide resistance and vector-borne disease outbreaks. This study evaluated the susceptibility and host responses of two important mosquito vectors, Ae. albopictus and Cx. pipiens, that naturally carry Wolbachia, to infections by entomopathogenic fungi. Our study indicated that while Wolbachia presence did not provide a protective advantage against entomopathogenic fungal infection, it nevertheless influenced the bacterial / fungal load and the expression of select anti-microbial effectors and phenoloxidase cascade genes in mosquitoes. Furthermore, although host responses from Ae. albopictus and Cx. pipiens were mostly similar, we observed contrasting phenotypes with regards to susceptibility and immune responses to fungal entomopathogenic infection in these two mosquitoes. This study provides new insights into the intricate multipartite interaction between the mosquito host, its native symbiont and pathogenic microbes that might be employed to control mosquito populations. |
| doi_str_mv | 10.1371/journal.pntd.0009984 |
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genetics</topic><topic>Monophenol Monooxygenase - metabolism</topic><topic>Mosquito Vectors - immunology</topic><topic>Mosquito Vectors - microbiology</topic><topic>Mosquitoes</topic><topic>Pathogens</topic><topic>Pest outbreaks</topic><topic>Pesticide resistance</topic><topic>Phenoloxidase</topic><topic>Phenotypes</topic><topic>Physiological aspects</topic><topic>Public health</topic><topic>Sucrose</topic><topic>Survival</topic><topic>Symbionts</topic><topic>Symbiosis</topic><topic>Tropical diseases</topic><topic>Vector Borne Diseases</topic><topic>Vectors</topic><topic>Wolbachia</topic><topic>Wolbachia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramirez, Jose L</creatorcontrib><creatorcontrib>Schumacher, Molly K</creatorcontrib><creatorcontrib>Ower, Geoff</creatorcontrib><creatorcontrib>Palmquist, Debra E</creatorcontrib><creatorcontrib>Juliano, Steven A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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This study evaluated the susceptibility and host responses of two important mosquito vectors, Ae. albopictus and Cx. pipiens, that naturally carry Wolbachia, to infections by entomopathogenic fungi. Our study indicated that while Wolbachia presence did not provide a protective advantage against entomopathogenic fungal infection, it nevertheless influenced the bacterial / fungal load and the expression of select anti-microbial effectors and phenoloxidase cascade genes in mosquitoes. Furthermore, although host responses from Ae. albopictus and Cx. pipiens were mostly similar, we observed contrasting phenotypes with regards to susceptibility and immune responses to fungal entomopathogenic infection in these two mosquitoes. This study provides new insights into the intricate multipartite interaction between the mosquito host, its native symbiont and pathogenic microbes that might be employed to control mosquito populations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34843477</pmid><doi>10.1371/journal.pntd.0009984</doi><orcidid>https://orcid.org/0000-0001-9607-1097</orcidid><orcidid>https://orcid.org/0000-0002-6178-4553</orcidid><orcidid>https://orcid.org/0000-0003-0847-1715</orcidid><orcidid>https://orcid.org/0000-0002-9770-2345</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aedes Aedes - drug effects Aedes - genetics Aedes - immunology Aedes - microbiology Aedes albopictus Animals Antiinfectives and antibacterials Aquatic insects Bacteria Bioassays Biological assays Biological control Biology and Life Sciences Culex - drug effects Culex - genetics Culex - immunology Culex - microbiology Culicidae Disease outbreaks Disease resistance Eggs Entomopathogenic fungi Fungal infections Fungi Gene Expression Genes Immune response Immune system Immunity - genetics Infections Infectious diseases Insect pests Insecticide Resistance Insecticides Insects Insects as carriers of disease Medicine and Health Sciences Microbiota Microorganisms Monophenol Monooxygenase - genetics Monophenol Monooxygenase - metabolism Mosquito Vectors - immunology Mosquito Vectors - microbiology Mosquitoes Pathogens Pest outbreaks Pesticide resistance Phenoloxidase Phenotypes Physiological aspects Public health Sucrose Survival Symbionts Symbiosis Tropical diseases Vector Borne Diseases Vectors Wolbachia Wolbachia - genetics |
| title | Impacts of fungal entomopathogens on survival and immune responses of Aedes albopictus and Culex pipiens mosquitoes in the context of native Wolbachia infections |
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