Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function

The medial habenula (mHb) is an understudied small brain nucleus linking forebrain and midbrain structures controlling anxiety and fear behaviors. The mechanisms that maintain the structural and functional integrity of mHb neurons and their synapses remain unknown. Using spatiotemporally controlled...

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Veröffentlicht in:	PLoS biology 2021-11, Vol.19 (11), p.e3001350-e3001350
Hauptverfasser:	Fernández-Suárez, Diana, Krapacher, Favio A, Pietrajtis, Katarzyna, Andersson, Annika, Kisiswa, Lilian, Carrier-Ruiz, Alvaro, Diana, Marco A, Ibáñez, Carlos F
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Aging Animals Anxiety Anxiety - physiopathology Behavior, Animal Biology and Life Sciences Brain Calcium ions Calcium permeability Cell adhesion & migration Circuits Cre recombinase Engineering and Technology Fear Fear - physiology Forebrain Glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism Glial cells Glutamatergic transmission Glutamates - metabolism Habenula Habenula - metabolism Life Sciences Mammals Medicine and Health Sciences Mesencephalon Mice Mice, Inbred C57BL Nerve Net - physiology Nervous system Neural networks Neuronal-glial interactions Neurons Neurons - metabolism Neurons and Cognition Neurotrophin receptors Presynaptic Terminals Proteins Receptors Receptors, AMPA - metabolism Recombination Research and Analysis Methods Social Sciences Stability Structure-function relationships Synapses Synaptic plasticity α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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