ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells

Epstein-Barr virus (EBV) is a human herpesvirus that causes infectious mononucleosis and contributes to both B-cell and epithelial-cell malignancies. EBV-infected epithelial cell tumors, including nasopharyngeal carcinoma (NPC), are largely composed of latently infected cells, but the mechanism(s) m...

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Veröffentlicht in:	PLoS pathogens 2021-11, Vol.17 (11), p.e1010045-e1010045
Hauptverfasser:	Van Sciver, Nicholas, Ohashi, Makoto, Nawandar, Dhananjay M, Pauly, Nicholas P, Lee, Denis, Makielski, Kathleen R, Bristol, Jillian A, Tsao, Sai Wah, Lambert, Paul F, Johannsen, Eric C, Kenney, Shannon C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing B-cell lymphoma Biology and Life Sciences Burkitt's lymphoma BZLF1 protein c-Myc protein Cancer Cell cycle Cell Differentiation Cell proliferation Cell survival Chemotherapy Differentiation (biology) DNA methylation DNA polymerase Epithelial cells Epithelial Cells - virology Epithelium Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - virology Gene expression Genomes Herpesvirus 4, Human - pathogenicity Host-Pathogen Interactions Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Infections Infectious mononucleosis Keratinocytes - virology Kinases KLF4 protein Latency Latent infection Lymphocytes B Lymphoma Medicine and Health Sciences Mononucleosis Myc protein Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Carcinoma - pathology Nasopharyngeal Carcinoma - virology Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - virology p53 Protein Platinum Proteins Research and Analysis Methods Stem cells Telomerase Throat cancer Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Virus Activation Virus Latency Viruses
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