The gammaherpesvirus 68 viral cyclin facilitates expression of LANA

Gammaherpesviruses establish life-long infections within their host and have been shown to be the causative agents of devastating malignancies. Chronic infection within the host is mediated through cycles of transcriptionally quiescent stages of latency with periods of reactivation into detectable l...

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Veröffentlicht in:	PLoS pathogens 2021-11, Vol.17 (11), p.e1010019-e1010019
Hauptverfasser:	Niemeyer, Brian F, Sanford, Bridget, Gibson, Joy E, Berger, Jennifer N, Oko, Lauren M, Medina, Eva, Clambey, Eric T, van Dyk, Linda F
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antigens, Viral - genetics Antigens, Viral - metabolism Biology and Life Sciences Cell culture Cell cycle Chronic infection Cyclin-dependent kinases Cyclins Cyclins - genetics Cyclins - metabolism Disruption Distribution Epstein-Barr virus Fibroblasts Flow cytometry Fusion protein Gammaherpesvirinae - physiology Gene expression Gene Expression Regulation, Viral Genetic aspects Genomes Herpesviridae Infections - metabolism Herpesviridae Infections - virology Herpesviruses Host-virus relationships Immunodeficiency Infections Kinases Latency Latent infection Lymphoma Medicine and Health Sciences Mice Mice, Inbred C57BL Nuclear Proteins - genetics Nuclear Proteins - metabolism Persistent Infection Physiological aspects Research and Analysis Methods Sarcoma Transcription Viral Proteins - genetics Viral Proteins - metabolism Virus Activation Virus Latency Virus Replication Viruses β Lactamase
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