Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence

PfSPZ Vaccine against malaria is composed of Plasmodium falciparum (Pf) sporozoites (SPZ) manufactured using aseptically reared Anopheles stephensi mosquitoes. Immune response genes of Anopheles mosquitoes such as Leucin-Rich protein (LRIM1), inhibit Plasmodium SPZ development (sporogony) in mosquit...

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Veröffentlicht in:	PLoS pathogens 2021-11, Vol.17 (11), p.e1009770-e1009770
Hauptverfasser:	Inbar, Ehud, Eappen, Abraham G, Alford, Robert T, Reid, William, Harrell, Robert A, Hosseini, Maryam, Chakravarty, Sumana, Li, Tao, Sim, B Kim Lee, Billingsley, Peter F, Hoffman, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acetic acid bacteria Analysis Animals Anopheles Anopheles - physiology Anopheles stephensi Antibiotics Aquatic insects Attenuation Bacteria Bacteria - growth & development Bacterial infections Biology and Life Sciences Care and treatment CRISPR CRISPR-Cas Systems Culicidae Deletion Diagnosis Digestive System - microbiology Dosage and administration Eggs Embryos Engineering and Technology Fecundity Female Females Fertility Gene deletion Genetic aspects Genome editing Genomes Identification and classification Immune response Immune system Infections Insect Proteins - antagonists & inhibitors Insect Proteins - genetics Insect Proteins - metabolism Malaria Malaria - parasitology Malaria vaccine Male Medicine and Health Sciences Melanization Microbiomes Midgut Mosquito Vectors - genetics Mosquito Vectors - growth & development Mosquito Vectors - parasitology Mosquitoes Oviposition Parasites Phagocytosis Plasmodium - growth & development Plasmodium falciparum Prevention Proteins Reproduction Research and Analysis Methods Risk factors Sporogony Sporozoites Survival Vaccines Vector-borne diseases Zygotes
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