Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit
Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess whether cortical thickness di...
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| Veröffentlicht in: | PloS one 2021-12, Vol.16 (12), p.e0261208-e0261208 |
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| creator | Cabral, Rafael Ferracini Corrêa, Diogo Goulart Zimmermann, Nicolle Tukamoto, Gustavo Kubo, Tadeu Takao Almodovar Fonseca, Rochele Paz Silva, Marcos Martins Wilner, Nina Ventura Bahia, Paulo Roberto Valle Gasparetto, Emerson Leandro Marchiori, Edson |
| description | Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess whether cortical thickness differs between HIV-infected patients with and without working memory deficit.
Forty-one adult HIV-infected patients with and without working memory deficit were imaged on a 1.5 T scanner. Working memory deficit was classified by composite Z scores for performance on the Digits and Letter-Number Sequencing subtests of the Wechsler Adult Intelligence Scale (third edition; WAIS-III). Cortical thickness was determined using FreeSurfer software. Differences in mean cortical thickness between groups, corrected for multiple comparisons using Monte-Carlo simulation, were examined using the query design estimate contrast tool of the FreeSurfer software.
Greater cortical thickness in left pars opercularis of the inferior frontal gyrus, and rostral and caudal portions of the left middle frontal gyrus (cluster 1; p = .004), and left superior frontal gyrus (cluster 2; p = .004) was observed in HIV-infected patients with working memory deficit compared with those without such deficit. Negative correlations were found between WAIS-III-based Z scores and cortical thickness in the two clusters (cluster 1: ρ = -0.59; cluster 2: ρ = -0.47).
HIV-infected patients with working memory deficit have regions of greater thickness in the left frontal cortices compared with those without such deficit, which may reflect increased synaptic contacts and/or an inflammatory response related to the damage caused by HIV infection. |
| doi_str_mv | 10.1371/journal.pone.0261208 |
| format | Article |
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Forty-one adult HIV-infected patients with and without working memory deficit were imaged on a 1.5 T scanner. Working memory deficit was classified by composite Z scores for performance on the Digits and Letter-Number Sequencing subtests of the Wechsler Adult Intelligence Scale (third edition; WAIS-III). Cortical thickness was determined using FreeSurfer software. Differences in mean cortical thickness between groups, corrected for multiple comparisons using Monte-Carlo simulation, were examined using the query design estimate contrast tool of the FreeSurfer software.
Greater cortical thickness in left pars opercularis of the inferior frontal gyrus, and rostral and caudal portions of the left middle frontal gyrus (cluster 1; p = .004), and left superior frontal gyrus (cluster 2; p = .004) was observed in HIV-infected patients with working memory deficit compared with those without such deficit. Negative correlations were found between WAIS-III-based Z scores and cortical thickness in the two clusters (cluster 1: ρ = -0.59; cluster 2: ρ = -0.47).
HIV-infected patients with working memory deficit have regions of greater thickness in the left frontal cortices compared with those without such deficit, which may reflect increased synaptic contacts and/or an inflammatory response related to the damage caused by HIV infection.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0261208</identifier><identifier>PMID: 34890434</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Analysis ; Attention ; Biology and Life Sciences ; Brain ; Brazil - epidemiology ; Care and treatment ; Cerebral cortex ; Cerebral Cortex - pathology ; Cerebral Cortex - virology ; Clusters ; Cocaine ; Cognition ; Cognition disorders ; Cognitive ability ; Comparative studies ; Computer programs ; Contraindications ; Dementia ; Diagnosis ; Ecstasy ; Female ; Frontal gyrus ; HIV ; HIV - isolation & purification ; HIV Infections - epidemiology ; HIV Infections - pathology ; HIV Infections - psychology ; HIV Infections - virology ; HIV patients ; Human immunodeficiency virus ; Humans ; Infections ; Inflammation ; Inflammatory response ; Intelligence ; Male ; Measurement ; Medicine and Health Sciences ; Memory ; Memory Disorders - epidemiology ; Memory Disorders - pathology ; Memory Disorders - psychology ; Memory Disorders - virology ; Memory, Short-Term - physiology ; Middle Aged ; Monte Carlo simulation ; Mortality ; Neuroimaging ; Neuropsychological Tests ; Neuropsychology ; Quality of life ; Ratings & rankings ; Research and Analysis Methods ; Risk factors ; Sequences ; Short term memory ; Social Sciences ; Software ; Thickness</subject><ispartof>PloS one, 2021-12, Vol.16 (12), p.e0261208-e0261208</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Cabral et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Cabral et al 2021 Cabral et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1a96fd962f3f13cc5e32cbe7fd5bb19a7df7b009013b9da05bf01f18fcc32ec23</citedby><cites>FETCH-LOGICAL-c692t-1a96fd962f3f13cc5e32cbe7fd5bb19a7df7b009013b9da05bf01f18fcc32ec23</cites><orcidid>0000-0002-7886-1164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664225/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664225/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34890434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cysique, Lucette A.</contributor><creatorcontrib>Cabral, Rafael Ferracini</creatorcontrib><creatorcontrib>Corrêa, Diogo Goulart</creatorcontrib><creatorcontrib>Zimmermann, Nicolle</creatorcontrib><creatorcontrib>Tukamoto, Gustavo</creatorcontrib><creatorcontrib>Kubo, Tadeu Takao Almodovar</creatorcontrib><creatorcontrib>Fonseca, Rochele Paz</creatorcontrib><creatorcontrib>Silva, Marcos Martins</creatorcontrib><creatorcontrib>Wilner, Nina Ventura</creatorcontrib><creatorcontrib>Bahia, Paulo Roberto Valle</creatorcontrib><creatorcontrib>Gasparetto, Emerson Leandro</creatorcontrib><creatorcontrib>Marchiori, Edson</creatorcontrib><title>Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess whether cortical thickness differs between HIV-infected patients with and without working memory deficit.
Forty-one adult HIV-infected patients with and without working memory deficit were imaged on a 1.5 T scanner. Working memory deficit was classified by composite Z scores for performance on the Digits and Letter-Number Sequencing subtests of the Wechsler Adult Intelligence Scale (third edition; WAIS-III). Cortical thickness was determined using FreeSurfer software. Differences in mean cortical thickness between groups, corrected for multiple comparisons using Monte-Carlo simulation, were examined using the query design estimate contrast tool of the FreeSurfer software.
Greater cortical thickness in left pars opercularis of the inferior frontal gyrus, and rostral and caudal portions of the left middle frontal gyrus (cluster 1; p = .004), and left superior frontal gyrus (cluster 2; p = .004) was observed in HIV-infected patients with working memory deficit compared with those without such deficit. Negative correlations were found between WAIS-III-based Z scores and cortical thickness in the two clusters (cluster 1: ρ = -0.59; cluster 2: ρ = -0.47).
HIV-infected patients with working memory deficit have regions of greater thickness in the left frontal cortices compared with those without such deficit, which may reflect increased synaptic contacts and/or an inflammatory response related to the damage caused by HIV infection.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Attention</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Brazil - epidemiology</subject><subject>Care and treatment</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - virology</subject><subject>Clusters</subject><subject>Cocaine</subject><subject>Cognition</subject><subject>Cognition disorders</subject><subject>Cognitive ability</subject><subject>Comparative studies</subject><subject>Computer programs</subject><subject>Contraindications</subject><subject>Dementia</subject><subject>Diagnosis</subject><subject>Ecstasy</subject><subject>Female</subject><subject>Frontal gyrus</subject><subject>HIV</subject><subject>HIV - isolation & purification</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - pathology</subject><subject>HIV Infections - psychology</subject><subject>HIV Infections - virology</subject><subject>HIV patients</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Intelligence</subject><subject>Male</subject><subject>Measurement</subject><subject>Medicine and Health Sciences</subject><subject>Memory</subject><subject>Memory Disorders - epidemiology</subject><subject>Memory Disorders - pathology</subject><subject>Memory Disorders - psychology</subject><subject>Memory Disorders - 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cabral, Rafael Ferracini</au><au>Corrêa, Diogo Goulart</au><au>Zimmermann, Nicolle</au><au>Tukamoto, Gustavo</au><au>Kubo, Tadeu Takao Almodovar</au><au>Fonseca, Rochele Paz</au><au>Silva, Marcos Martins</au><au>Wilner, Nina Ventura</au><au>Bahia, Paulo Roberto Valle</au><au>Gasparetto, Emerson Leandro</au><au>Marchiori, Edson</au><au>Cysique, Lucette A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-12-10</date><risdate>2021</risdate><volume>16</volume><issue>12</issue><spage>e0261208</spage><epage>e0261208</epage><pages>e0261208-e0261208</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess whether cortical thickness differs between HIV-infected patients with and without working memory deficit.
Forty-one adult HIV-infected patients with and without working memory deficit were imaged on a 1.5 T scanner. Working memory deficit was classified by composite Z scores for performance on the Digits and Letter-Number Sequencing subtests of the Wechsler Adult Intelligence Scale (third edition; WAIS-III). Cortical thickness was determined using FreeSurfer software. Differences in mean cortical thickness between groups, corrected for multiple comparisons using Monte-Carlo simulation, were examined using the query design estimate contrast tool of the FreeSurfer software.
Greater cortical thickness in left pars opercularis of the inferior frontal gyrus, and rostral and caudal portions of the left middle frontal gyrus (cluster 1; p = .004), and left superior frontal gyrus (cluster 2; p = .004) was observed in HIV-infected patients with working memory deficit compared with those without such deficit. Negative correlations were found between WAIS-III-based Z scores and cortical thickness in the two clusters (cluster 1: ρ = -0.59; cluster 2: ρ = -0.47).
HIV-infected patients with working memory deficit have regions of greater thickness in the left frontal cortices compared with those without such deficit, which may reflect increased synaptic contacts and/or an inflammatory response related to the damage caused by HIV infection.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34890434</pmid><doi>10.1371/journal.pone.0261208</doi><tpages>e0261208</tpages><orcidid>https://orcid.org/0000-0002-7886-1164</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-12, Vol.16 (12), p.e0261208-e0261208 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2608861295 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Analysis Attention Biology and Life Sciences Brain Brazil - epidemiology Care and treatment Cerebral cortex Cerebral Cortex - pathology Cerebral Cortex - virology Clusters Cocaine Cognition Cognition disorders Cognitive ability Comparative studies Computer programs Contraindications Dementia Diagnosis Ecstasy Female Frontal gyrus HIV HIV - isolation & purification HIV Infections - epidemiology HIV Infections - pathology HIV Infections - psychology HIV Infections - virology HIV patients Human immunodeficiency virus Humans Infections Inflammation Inflammatory response Intelligence Male Measurement Medicine and Health Sciences Memory Memory Disorders - epidemiology Memory Disorders - pathology Memory Disorders - psychology Memory Disorders - virology Memory, Short-Term - physiology Middle Aged Monte Carlo simulation Mortality Neuroimaging Neuropsychological Tests Neuropsychology Quality of life Ratings & rankings Research and Analysis Methods Risk factors Sequences Short term memory Social Sciences Software Thickness |
| title | Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T23%3A18%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preliminary%20comparative%20study%20of%20cortical%20thickness%20in%20HIV-infected%20patients%20with%20and%20without%20working%20memory%20deficit&rft.jtitle=PloS%20one&rft.au=Cabral,%20Rafael%20Ferracini&rft.date=2021-12-10&rft.volume=16&rft.issue=12&rft.spage=e0261208&rft.epage=e0261208&rft.pages=e0261208-e0261208&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0261208&rft_dat=%3Cgale_plos_%3EA686267640%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2608861295&rft_id=info:pmid/34890434&rft_galeid=A686267640&rft_doaj_id=oai_doaj_org_article_4428d16c2d864d5fabb8cb6fca820305&rfr_iscdi=true |