A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia
Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar,...
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| description | Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar, eastern Ethiopia.
A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant's socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. Spearman's correlation was used for correlation test. P values less than 0.05 was considered as statistically significant.
102 hypertensive and 102 healthy controls were enrolled in this study. The median ± IQR value of white blood cell (WBC) count, hemoglobin (Hgb), hematocrit (HCT), red cell distribution width (RDW) and mean platelet volume (MPV) were significantly higher in hypertensive group compared to apparently healthy control group. Additionally, RBC (red blood cell) count, HCT and RDW showed statistically significant positive correlations with systolic and diastolic blood pressure. WBC count and RDW were significantly and positively correlated with body mass index (BMI). Platelet (PLT) count had a significant but negative correlation (r = -0.219, P = 0.027) with duration of hypertension illness while MPV showed positive and significant correlation (r = 0.255, P = 0.010).
The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertensive patient compared to apparently healthy individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further studies are required to understand hypertensive associated changes in hematological parameters. |
| doi_str_mv | 10.1371/journal.pone.0260751 |
| format | Article |
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A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant's socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. Spearman's correlation was used for correlation test. P values less than 0.05 was considered as statistically significant.
102 hypertensive and 102 healthy controls were enrolled in this study. The median ± IQR value of white blood cell (WBC) count, hemoglobin (Hgb), hematocrit (HCT), red cell distribution width (RDW) and mean platelet volume (MPV) were significantly higher in hypertensive group compared to apparently healthy control group. Additionally, RBC (red blood cell) count, HCT and RDW showed statistically significant positive correlations with systolic and diastolic blood pressure. WBC count and RDW were significantly and positively correlated with body mass index (BMI). Platelet (PLT) count had a significant but negative correlation (r = -0.219, P = 0.027) with duration of hypertension illness while MPV showed positive and significant correlation (r = 0.255, P = 0.010).
The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertensive patient compared to apparently healthy individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further studies are required to understand hypertensive associated changes in hematological parameters.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0260751</identifier><identifier>PMID: 34874952</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Biology and Life Sciences ; Biomarkers - analysis ; Blood & organ donations ; Blood banks ; Blood donors ; Blood Pressure ; Blood tests ; Body mass ; Body Mass Index ; Body size ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Case-Control Studies ; Chronic illnesses ; Comparative studies ; Complications ; Correlation ; Cross-Sectional Studies ; Data collection ; Diagnosis ; Erythrocytes ; Female ; Follow-Up Studies ; Hematocrit ; Hematology ; Hemoglobin ; Hemoglobins - analysis ; Hospitals ; Humans ; Hypertension ; Hypertension - blood ; Hypertension - epidemiology ; Hypertension - pathology ; Leukocytes ; Male ; Medical laboratories ; Medical records ; Medicine and Health Sciences ; Middle Aged ; Parameters ; Patients ; People and Places ; Phlebotomy ; Platelets ; Prognosis ; Public health ; Questionnaires ; Risk factors ; Sampling methods ; Sampling techniques ; Statistical analysis ; Young Adult</subject><ispartof>PloS one, 2021-12, Vol.16 (12), p.e0260751-e0260751</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Sileshi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Sileshi et al 2021 Sileshi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f32d0f5144a2f856ca6312adf787ddd60f1b5ae7fe4ff531778e45dd56a6ea693</citedby><cites>FETCH-LOGICAL-c692t-f32d0f5144a2f856ca6312adf787ddd60f1b5ae7fe4ff531778e45dd56a6ea693</cites><orcidid>0000-0003-2097-6003</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651120/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651120/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34874952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Johnson, Colin</contributor><creatorcontrib>Sileshi, Beza</creatorcontrib><creatorcontrib>Urgessa, Fekadu</creatorcontrib><creatorcontrib>Wordofa, Moges</creatorcontrib><title>A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar, eastern Ethiopia.
A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant's socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. Spearman's correlation was used for correlation test. P values less than 0.05 was considered as statistically significant.
102 hypertensive and 102 healthy controls were enrolled in this study. The median ± IQR value of white blood cell (WBC) count, hemoglobin (Hgb), hematocrit (HCT), red cell distribution width (RDW) and mean platelet volume (MPV) were significantly higher in hypertensive group compared to apparently healthy control group. Additionally, RBC (red blood cell) count, HCT and RDW showed statistically significant positive correlations with systolic and diastolic blood pressure. WBC count and RDW were significantly and positively correlated with body mass index (BMI). Platelet (PLT) count had a significant but negative correlation (r = -0.219, P = 0.027) with duration of hypertension illness while MPV showed positive and significant correlation (r = 0.255, P = 0.010).
The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertensive patient compared to apparently healthy individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further studies are required to understand hypertensive associated changes in hematological parameters.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - analysis</subject><subject>Blood & organ donations</subject><subject>Blood banks</subject><subject>Blood donors</subject><subject>Blood Pressure</subject><subject>Blood tests</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Chronic illnesses</subject><subject>Comparative studies</subject><subject>Complications</subject><subject>Correlation</subject><subject>Cross-Sectional Studies</subject><subject>Data collection</subject><subject>Diagnosis</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hematocrit</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Hemoglobins - analysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - pathology</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medical laboratories</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Parameters</subject><subject>Patients</subject><subject>People and Places</subject><subject>Phlebotomy</subject><subject>Platelets</subject><subject>Prognosis</subject><subject>Public health</subject><subject>Questionnaires</subject><subject>Risk factors</subject><subject>Sampling methods</subject><subject>Sampling techniques</subject><subject>Statistical analysis</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgig4Y5M2aXsjDMvqDiws-HUbzjQnMxnaZDZJRwf88abzsczIXkgvGk6e983J254keUmyMclL8nFpe2egHa-swXFGeVYy8ig5J3VOR5xm-eOj9VnyzPtllrG84vxpcpYXVVnUjJ4nfyZpY7sVOAh6jakPvdykVqUL7CDY1s51A2067HcY0Pl0huEXokkXmxW6gMYPMjAyNdZ19lDQRuq1lj20Pq7T66h3H1IEHz1MehUW2q40PE-eqEjgi_37Ivnx-er75fXo5vbL9HJyM2p4TcNI5VRmipGiAKoqxhvgOaEgVVmVUkqeKTJjgKXCQimWk7KssGBSMg4cgdf5RfJ657tqrRf74LzYZlYzVmeRmO4IaWEpVk534DbCghbbgnVzAS7opkWRgeIZYxj7mRVSNjXUVM0KqhiL-c5U9Pq0P62fdSgbNMFBe2J6umP0QsztWlScEUKHZt7tDZy969EH0WnfYNuCQdtv-65ITlk-oG_-QR--3Z6aQ7yANsrGc5vBVEx4xcqCFoxEavwAFR-JnW7iX6Z0rJ8I3p8IIhPwd5hD772Yfvv6_-ztz1P27RG7QGjDwtu2D9oafwoWO7Bx1nuH6j5kkolhSA5piGFIxH5IouzV8Qe6Fx2mIv8LYCsPVw</recordid><startdate>20211207</startdate><enddate>20211207</enddate><creator>Sileshi, Beza</creator><creator>Urgessa, Fekadu</creator><creator>Wordofa, Moges</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2097-6003</orcidid></search><sort><creationdate>20211207</creationdate><title>A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia</title><author>Sileshi, Beza ; Urgessa, Fekadu ; Wordofa, Moges</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-f32d0f5144a2f856ca6312adf787ddd60f1b5ae7fe4ff531778e45dd56a6ea693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sileshi, Beza</au><au>Urgessa, Fekadu</au><au>Wordofa, Moges</au><au>Johnson, Colin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-12-07</date><risdate>2021</risdate><volume>16</volume><issue>12</issue><spage>e0260751</spage><epage>e0260751</epage><pages>e0260751-e0260751</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar, eastern Ethiopia.
A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant's socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. Spearman's correlation was used for correlation test. P values less than 0.05 was considered as statistically significant.
102 hypertensive and 102 healthy controls were enrolled in this study. The median ± IQR value of white blood cell (WBC) count, hemoglobin (Hgb), hematocrit (HCT), red cell distribution width (RDW) and mean platelet volume (MPV) were significantly higher in hypertensive group compared to apparently healthy control group. Additionally, RBC (red blood cell) count, HCT and RDW showed statistically significant positive correlations with systolic and diastolic blood pressure. WBC count and RDW were significantly and positively correlated with body mass index (BMI). Platelet (PLT) count had a significant but negative correlation (r = -0.219, P = 0.027) with duration of hypertension illness while MPV showed positive and significant correlation (r = 0.255, P = 0.010).
The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertensive patient compared to apparently healthy individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further studies are required to understand hypertensive associated changes in hematological parameters.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34874952</pmid><doi>10.1371/journal.pone.0260751</doi><tpages>e0260751</tpages><orcidid>https://orcid.org/0000-0003-2097-6003</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Biology and Life Sciences Biomarkers - analysis Blood & organ donations Blood banks Blood donors Blood Pressure Blood tests Body mass Body Mass Index Body size Cardiovascular disease Cardiovascular diseases Care and treatment Case-Control Studies Chronic illnesses Comparative studies Complications Correlation Cross-Sectional Studies Data collection Diagnosis Erythrocytes Female Follow-Up Studies Hematocrit Hematology Hemoglobin Hemoglobins - analysis Hospitals Humans Hypertension Hypertension - blood Hypertension - epidemiology Hypertension - pathology Leukocytes Male Medical laboratories Medical records Medicine and Health Sciences Middle Aged Parameters Patients People and Places Phlebotomy Platelets Prognosis Public health Questionnaires Risk factors Sampling methods Sampling techniques Statistical analysis Young Adult |
| title | A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T20%3A18%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20comparative%20study%20of%20hematological%20parameters%20between%20hypertensive%20and%20normotensive%20individuals%20in%20Harar,%20eastern%20Ethiopia&rft.jtitle=PloS%20one&rft.au=Sileshi,%20Beza&rft.date=2021-12-07&rft.volume=16&rft.issue=12&rft.spage=e0260751&rft.epage=e0260751&rft.pages=e0260751-e0260751&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0260751&rft_dat=%3Cgale_plos_%3EA685742451%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2607595590&rft_id=info:pmid/34874952&rft_galeid=A685742451&rft_doaj_id=oai_doaj_org_article_0af6055e514b4ddc9a92fb42f55053bf&rfr_iscdi=true |