Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis

The tenosynovial giant cell tumor (TGCT) is a usually benign lesion which arises from the synovium. It affects joints, tendon sheaths and bursae. The clinical course is often unpredictable, and local recurrences frequently occur. The aim of this study was to describe different treatment options, sur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2021-12, Vol.16 (12), p.e0260795-e0260795
Hauptverfasser: Siegel, M, Bode, L, Südkamp, N, Kühle, J, Zwingmann, J, Schmal, H, Herget, G W
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page e0260795
container_issue 12
container_start_page e0260795
container_title PloS one
container_volume 16
creator Siegel, M
Bode, L
Südkamp, N
Kühle, J
Zwingmann, J
Schmal, H
Herget, G W
description The tenosynovial giant cell tumor (TGCT) is a usually benign lesion which arises from the synovium. It affects joints, tendon sheaths and bursae. The clinical course is often unpredictable, and local recurrences frequently occur. The aim of this study was to describe different treatment options, surgical complications, and to develop a follow-up regime based on a systematic literature review and meta-analysis of foot and ankle lesions. 1284 studies published between 01/1966 and 06/2021 were identified. 25 met the inclusion criteria, with a total of 382 patients. Of these, 212 patients had a diffuse (dTGCT) and 170 a localized (lTGCT) TGCT. Patients with a dTGCT had a mean age of 36.6±8.2 years, and 55% were female. The overall complication rate was 24% in dTGCT, irrespective of the therapeutic procedure; the mean follow-up was 37.9±27.4 months with a recurrence rate of 21%, and recurrences occurred between 3 and 144 months, the vast majority (86%) within the first 5 years following intervention. Patients with a lTGCT had a mean age of 31.2±5.7 years, and 53% were female. Complications occurred in 12%. The mean follow-up was 51.1±24.6 months, the recurrence rate was 7%, and recurrence occurred between 1 and 244 months after intervention. Diffuse TGCTs of the foot and ankle region have a remarkable recurrence rate irrespective of therapeutic procedures, and most lesions reoccurred within 5, with more than half of these in the first 2 years. The lTGCTs are well treatable lesions, with a low recurrence and a moderate complication rate. Based on these findings, we propose a follow-up regime for the dTGCT including a clinical survey and MR imaging 3 months after surgical intervention (baseline), followed by twice-yearly intervals for the first 2 years, yearly intervals up to the fifth year, and further individual follow-up due to the fact that recurrences can even occur for years later. For the lTGCT a clinical survey and MRT is proposed after 3-6 months after intervention (baseline), followed by annual clinical examination for 3 years, and in case of symptoms MR-imaging. Larger prospective multi-center studies are necessary to confirm these results and recommendations.
doi_str_mv 10.1371/journal.pone.0260795
format Article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2605598831</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A684621179</galeid><doaj_id>oai_doaj_org_article_4ba64c3079f34c0587b3533bd81a2999</doaj_id><sourcerecordid>A684621179</sourcerecordid><originalsourceid>FETCH-LOGICAL-c659t-8c15cad846136a8d5a686cf155bb4d537ec268b651fd74ea06a6e532396df5d83</originalsourceid><addsrcrecordid>eNptUsFu1DAUjBCIlsIfIIjEpUhkiePYcS6VVitYKlXiEs7Wi_Oy9ZLYi51stR_BP-PsplWLmhwS2TPz3owmit6TdEFoQb5u7egMdIudNbhIM54WJXsRnZOSZgnPUvry0f9Z9Mb7bZoyKjh_HZ3RXDAmCnYe_a0cwtCjGb7EDtXoHBqFsYMBfQymiVvbdfYuGXexbeMKjfUHY_caunitwQzxCrsursbeuviyWq-qzxNuuMVAtMNRAczvDpNl7A9-wB4GrcKkvca7422PAyQQjBy89m-jVy10Ht_N34vo1_dv1epHcvNzfb1a3iSKs3JIhCJMQSNyTigH0TDggquWMFbXecNogSrjouaMtE2RI6QcODKa0ZI3LWsEvYg-nnR3nfVyTtLLECJjpRCUBMT1CdFY2Mqd0z24g7Sg5fHAuo0EF6x0KPMaeK5oyL-luUpDrjVllNaNIJCVZRm0ruZpY91jo0LYDronok9vjL6VG7uXglMRniBwOQs4-2dEP8heexWCB4N2PO7Nyyxn6QT99B_0eXczagPBgDatDXPVJCqXPMSaEVJMey-eQYW3wV6rULtWh_MnhPxEUM5677B98EhSOZX2fhk5lVbOpQ20D4_zeSDdt5T-A-386cg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2605598831</pqid></control><display><type>article</type><title>Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Siegel, M ; Bode, L ; Südkamp, N ; Kühle, J ; Zwingmann, J ; Schmal, H ; Herget, G W</creator><contributor>Takeuchi, Akihiko</contributor><creatorcontrib>Siegel, M ; Bode, L ; Südkamp, N ; Kühle, J ; Zwingmann, J ; Schmal, H ; Herget, G W ; Takeuchi, Akihiko</creatorcontrib><description>The tenosynovial giant cell tumor (TGCT) is a usually benign lesion which arises from the synovium. It affects joints, tendon sheaths and bursae. The clinical course is often unpredictable, and local recurrences frequently occur. The aim of this study was to describe different treatment options, surgical complications, and to develop a follow-up regime based on a systematic literature review and meta-analysis of foot and ankle lesions. 1284 studies published between 01/1966 and 06/2021 were identified. 25 met the inclusion criteria, with a total of 382 patients. Of these, 212 patients had a diffuse (dTGCT) and 170 a localized (lTGCT) TGCT. Patients with a dTGCT had a mean age of 36.6±8.2 years, and 55% were female. The overall complication rate was 24% in dTGCT, irrespective of the therapeutic procedure; the mean follow-up was 37.9±27.4 months with a recurrence rate of 21%, and recurrences occurred between 3 and 144 months, the vast majority (86%) within the first 5 years following intervention. Patients with a lTGCT had a mean age of 31.2±5.7 years, and 53% were female. Complications occurred in 12%. The mean follow-up was 51.1±24.6 months, the recurrence rate was 7%, and recurrence occurred between 1 and 244 months after intervention. Diffuse TGCTs of the foot and ankle region have a remarkable recurrence rate irrespective of therapeutic procedures, and most lesions reoccurred within 5, with more than half of these in the first 2 years. The lTGCTs are well treatable lesions, with a low recurrence and a moderate complication rate. Based on these findings, we propose a follow-up regime for the dTGCT including a clinical survey and MR imaging 3 months after surgical intervention (baseline), followed by twice-yearly intervals for the first 2 years, yearly intervals up to the fifth year, and further individual follow-up due to the fact that recurrences can even occur for years later. For the lTGCT a clinical survey and MRT is proposed after 3-6 months after intervention (baseline), followed by annual clinical examination for 3 years, and in case of symptoms MR-imaging. Larger prospective multi-center studies are necessary to confirm these results and recommendations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0260795</identifier><identifier>PMID: 34855875</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Ankle ; Ankle - pathology ; Ankle - surgery ; Biology and Life Sciences ; Care and treatment ; Complications ; Diagnosis ; Diseases ; Evidence-based medicine ; Feet ; Females ; Follow-Up Studies ; Foot diseases ; Foot Diseases - pathology ; Foot Diseases - surgery ; Giant Cell Tumor of Tendon Sheath - pathology ; Giant Cell Tumor of Tendon Sheath - surgery ; Humans ; Intervals ; Lesions ; Literature reviews ; Localization ; Magnetic resonance imaging ; Medicine ; Medicine and Health Sciences ; Meta-analysis ; Neoplasm Recurrence, Local - etiology ; Neoplasm Recurrence, Local - pathology ; Orthopedics ; Patients ; Physical Sciences ; Polls &amp; surveys ; Postoperative Complications - etiology ; Postoperative Complications - pathology ; Radiation therapy ; Relapse ; Research and Analysis Methods ; Sheaths ; Surgery ; Surgical Procedures, Operative - adverse effects ; Surgical techniques ; Synovium ; Systematic review ; Tumors</subject><ispartof>PloS one, 2021-12, Vol.16 (12), p.e0260795-e0260795</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Siegel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Siegel et al 2021 Siegel et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-8c15cad846136a8d5a686cf155bb4d537ec268b651fd74ea06a6e532396df5d83</citedby><cites>FETCH-LOGICAL-c659t-8c15cad846136a8d5a686cf155bb4d537ec268b651fd74ea06a6e532396df5d83</cites><orcidid>0000-0002-9466-2157 ; 0000-0001-8755-6383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638888/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638888/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34855875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Takeuchi, Akihiko</contributor><creatorcontrib>Siegel, M</creatorcontrib><creatorcontrib>Bode, L</creatorcontrib><creatorcontrib>Südkamp, N</creatorcontrib><creatorcontrib>Kühle, J</creatorcontrib><creatorcontrib>Zwingmann, J</creatorcontrib><creatorcontrib>Schmal, H</creatorcontrib><creatorcontrib>Herget, G W</creatorcontrib><title>Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The tenosynovial giant cell tumor (TGCT) is a usually benign lesion which arises from the synovium. It affects joints, tendon sheaths and bursae. The clinical course is often unpredictable, and local recurrences frequently occur. The aim of this study was to describe different treatment options, surgical complications, and to develop a follow-up regime based on a systematic literature review and meta-analysis of foot and ankle lesions. 1284 studies published between 01/1966 and 06/2021 were identified. 25 met the inclusion criteria, with a total of 382 patients. Of these, 212 patients had a diffuse (dTGCT) and 170 a localized (lTGCT) TGCT. Patients with a dTGCT had a mean age of 36.6±8.2 years, and 55% were female. The overall complication rate was 24% in dTGCT, irrespective of the therapeutic procedure; the mean follow-up was 37.9±27.4 months with a recurrence rate of 21%, and recurrences occurred between 3 and 144 months, the vast majority (86%) within the first 5 years following intervention. Patients with a lTGCT had a mean age of 31.2±5.7 years, and 53% were female. Complications occurred in 12%. The mean follow-up was 51.1±24.6 months, the recurrence rate was 7%, and recurrence occurred between 1 and 244 months after intervention. Diffuse TGCTs of the foot and ankle region have a remarkable recurrence rate irrespective of therapeutic procedures, and most lesions reoccurred within 5, with more than half of these in the first 2 years. The lTGCTs are well treatable lesions, with a low recurrence and a moderate complication rate. Based on these findings, we propose a follow-up regime for the dTGCT including a clinical survey and MR imaging 3 months after surgical intervention (baseline), followed by twice-yearly intervals for the first 2 years, yearly intervals up to the fifth year, and further individual follow-up due to the fact that recurrences can even occur for years later. For the lTGCT a clinical survey and MRT is proposed after 3-6 months after intervention (baseline), followed by annual clinical examination for 3 years, and in case of symptoms MR-imaging. Larger prospective multi-center studies are necessary to confirm these results and recommendations.</description><subject>Ankle</subject><subject>Ankle - pathology</subject><subject>Ankle - surgery</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Complications</subject><subject>Diagnosis</subject><subject>Diseases</subject><subject>Evidence-based medicine</subject><subject>Feet</subject><subject>Females</subject><subject>Follow-Up Studies</subject><subject>Foot diseases</subject><subject>Foot Diseases - pathology</subject><subject>Foot Diseases - surgery</subject><subject>Giant Cell Tumor of Tendon Sheath - pathology</subject><subject>Giant Cell Tumor of Tendon Sheath - surgery</subject><subject>Humans</subject><subject>Intervals</subject><subject>Lesions</subject><subject>Literature reviews</subject><subject>Localization</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Neoplasm Recurrence, Local - etiology</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Polls &amp; surveys</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - pathology</subject><subject>Radiation therapy</subject><subject>Relapse</subject><subject>Research and Analysis Methods</subject><subject>Sheaths</subject><subject>Surgery</subject><subject>Surgical Procedures, Operative - adverse effects</subject><subject>Surgical techniques</subject><subject>Synovium</subject><subject>Systematic review</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUsFu1DAUjBCIlsIfIIjEpUhkiePYcS6VVitYKlXiEs7Wi_Oy9ZLYi51stR_BP-PsplWLmhwS2TPz3owmit6TdEFoQb5u7egMdIudNbhIM54WJXsRnZOSZgnPUvry0f9Z9Mb7bZoyKjh_HZ3RXDAmCnYe_a0cwtCjGb7EDtXoHBqFsYMBfQymiVvbdfYuGXexbeMKjfUHY_caunitwQzxCrsursbeuviyWq-qzxNuuMVAtMNRAczvDpNl7A9-wB4GrcKkvca7422PAyQQjBy89m-jVy10Ht_N34vo1_dv1epHcvNzfb1a3iSKs3JIhCJMQSNyTigH0TDggquWMFbXecNogSrjouaMtE2RI6QcODKa0ZI3LWsEvYg-nnR3nfVyTtLLECJjpRCUBMT1CdFY2Mqd0z24g7Sg5fHAuo0EF6x0KPMaeK5oyL-luUpDrjVllNaNIJCVZRm0ruZpY91jo0LYDronok9vjL6VG7uXglMRniBwOQs4-2dEP8heexWCB4N2PO7Nyyxn6QT99B_0eXczagPBgDatDXPVJCqXPMSaEVJMey-eQYW3wV6rULtWh_MnhPxEUM5677B98EhSOZX2fhk5lVbOpQ20D4_zeSDdt5T-A-386cg</recordid><startdate>20211202</startdate><enddate>20211202</enddate><creator>Siegel, M</creator><creator>Bode, L</creator><creator>Südkamp, N</creator><creator>Kühle, J</creator><creator>Zwingmann, J</creator><creator>Schmal, H</creator><creator>Herget, G W</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9466-2157</orcidid><orcidid>https://orcid.org/0000-0001-8755-6383</orcidid></search><sort><creationdate>20211202</creationdate><title>Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis</title><author>Siegel, M ; Bode, L ; Südkamp, N ; Kühle, J ; Zwingmann, J ; Schmal, H ; Herget, G W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-8c15cad846136a8d5a686cf155bb4d537ec268b651fd74ea06a6e532396df5d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ankle</topic><topic>Ankle - pathology</topic><topic>Ankle - surgery</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Complications</topic><topic>Diagnosis</topic><topic>Diseases</topic><topic>Evidence-based medicine</topic><topic>Feet</topic><topic>Females</topic><topic>Follow-Up Studies</topic><topic>Foot diseases</topic><topic>Foot Diseases - pathology</topic><topic>Foot Diseases - surgery</topic><topic>Giant Cell Tumor of Tendon Sheath - pathology</topic><topic>Giant Cell Tumor of Tendon Sheath - surgery</topic><topic>Humans</topic><topic>Intervals</topic><topic>Lesions</topic><topic>Literature reviews</topic><topic>Localization</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Neoplasm Recurrence, Local - etiology</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Orthopedics</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Polls &amp; surveys</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - pathology</topic><topic>Radiation therapy</topic><topic>Relapse</topic><topic>Research and Analysis Methods</topic><topic>Sheaths</topic><topic>Surgery</topic><topic>Surgical Procedures, Operative - adverse effects</topic><topic>Surgical techniques</topic><topic>Synovium</topic><topic>Systematic review</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siegel, M</creatorcontrib><creatorcontrib>Bode, L</creatorcontrib><creatorcontrib>Südkamp, N</creatorcontrib><creatorcontrib>Kühle, J</creatorcontrib><creatorcontrib>Zwingmann, J</creatorcontrib><creatorcontrib>Schmal, H</creatorcontrib><creatorcontrib>Herget, G W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siegel, M</au><au>Bode, L</au><au>Südkamp, N</au><au>Kühle, J</au><au>Zwingmann, J</au><au>Schmal, H</au><au>Herget, G W</au><au>Takeuchi, Akihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-12-02</date><risdate>2021</risdate><volume>16</volume><issue>12</issue><spage>e0260795</spage><epage>e0260795</epage><pages>e0260795-e0260795</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The tenosynovial giant cell tumor (TGCT) is a usually benign lesion which arises from the synovium. It affects joints, tendon sheaths and bursae. The clinical course is often unpredictable, and local recurrences frequently occur. The aim of this study was to describe different treatment options, surgical complications, and to develop a follow-up regime based on a systematic literature review and meta-analysis of foot and ankle lesions. 1284 studies published between 01/1966 and 06/2021 were identified. 25 met the inclusion criteria, with a total of 382 patients. Of these, 212 patients had a diffuse (dTGCT) and 170 a localized (lTGCT) TGCT. Patients with a dTGCT had a mean age of 36.6±8.2 years, and 55% were female. The overall complication rate was 24% in dTGCT, irrespective of the therapeutic procedure; the mean follow-up was 37.9±27.4 months with a recurrence rate of 21%, and recurrences occurred between 3 and 144 months, the vast majority (86%) within the first 5 years following intervention. Patients with a lTGCT had a mean age of 31.2±5.7 years, and 53% were female. Complications occurred in 12%. The mean follow-up was 51.1±24.6 months, the recurrence rate was 7%, and recurrence occurred between 1 and 244 months after intervention. Diffuse TGCTs of the foot and ankle region have a remarkable recurrence rate irrespective of therapeutic procedures, and most lesions reoccurred within 5, with more than half of these in the first 2 years. The lTGCTs are well treatable lesions, with a low recurrence and a moderate complication rate. Based on these findings, we propose a follow-up regime for the dTGCT including a clinical survey and MR imaging 3 months after surgical intervention (baseline), followed by twice-yearly intervals for the first 2 years, yearly intervals up to the fifth year, and further individual follow-up due to the fact that recurrences can even occur for years later. For the lTGCT a clinical survey and MRT is proposed after 3-6 months after intervention (baseline), followed by annual clinical examination for 3 years, and in case of symptoms MR-imaging. Larger prospective multi-center studies are necessary to confirm these results and recommendations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34855875</pmid><doi>10.1371/journal.pone.0260795</doi><orcidid>https://orcid.org/0000-0002-9466-2157</orcidid><orcidid>https://orcid.org/0000-0001-8755-6383</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2021-12, Vol.16 (12), p.e0260795-e0260795
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2605598831
source MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry
subjects Ankle
Ankle - pathology
Ankle - surgery
Biology and Life Sciences
Care and treatment
Complications
Diagnosis
Diseases
Evidence-based medicine
Feet
Females
Follow-Up Studies
Foot diseases
Foot Diseases - pathology
Foot Diseases - surgery
Giant Cell Tumor of Tendon Sheath - pathology
Giant Cell Tumor of Tendon Sheath - surgery
Humans
Intervals
Lesions
Literature reviews
Localization
Magnetic resonance imaging
Medicine
Medicine and Health Sciences
Meta-analysis
Neoplasm Recurrence, Local - etiology
Neoplasm Recurrence, Local - pathology
Orthopedics
Patients
Physical Sciences
Polls & surveys
Postoperative Complications - etiology
Postoperative Complications - pathology
Radiation therapy
Relapse
Research and Analysis Methods
Sheaths
Surgery
Surgical Procedures, Operative - adverse effects
Surgical techniques
Synovium
Systematic review
Tumors
title Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T22%3A41%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Treatment,%20recurrence%20rates%20and%20follow-up%20of%20Tenosynovial%20Giant%20Cell%20Tumor%20(TGCT)%20of%20the%20foot%20and%20ankle-A%20systematic%20review%20and%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Siegel,%20M&rft.date=2021-12-02&rft.volume=16&rft.issue=12&rft.spage=e0260795&rft.epage=e0260795&rft.pages=e0260795-e0260795&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0260795&rft_dat=%3Cgale_plos_%3EA684621179%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2605598831&rft_id=info:pmid/34855875&rft_galeid=A684621179&rft_doaj_id=oai_doaj_org_article_4ba64c3079f34c0587b3533bd81a2999&rfr_iscdi=true