Intrathecal IGF2 siRNA injection provides long-lasting anti-allodynic effect in a spared nerve injury rat model of neuropathic pain

Previous studies have shown an increase of insulin-like growth factor-2 (IGF2) in animal models of neuropathic pain. We aimed to examine the hypothesis that reducing the expression of IGF2 using intrathecal IGF2 small-interfering RNA (siRNA) would attenuate the development of neuropathic pain in rat...

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Veröffentlicht in:	PloS one 2021-12, Vol.16 (12), p.e0260887-e0260887
Hauptverfasser:	Chan, Wei-Hung, Huang, Nian-Cih, Lin, Yi-Wen, Lin, Feng-Yen, Tsai, Chien-Sung, Yeh, Chun-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone Analgesics Analysis Anesthesiology Animal models Animals Biology and life sciences Disease Models, Animal Experiments Gene expression Genes Growth factors Health aspects Hospitals Hyperalgesia - etiology Hyperalgesia - metabolism Hyperalgesia - pathology Hyperalgesia - therapy Injections, Spinal Injuries Insulin Insulin-like growth factor II Insulin-Like Growth Factor II - antagonists & inhibitors Insulin-Like Growth Factor II - genetics Insulin-like growth factors Laboratory animals Male Medicine and Health Sciences Metal fibers Muscles Nerves Nervous system Neuralgia Neuralgia - etiology Neuralgia - metabolism Neuralgia - pathology Neuralgia - therapy Neuropathy Pain Pain perception Peripheral Nerve Injuries - complications Polymerase chain reaction Proteins Rats Rats, Wistar Research and Analysis Methods RNA RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics siRNA Spinal cord Surgery
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