7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy

Retinopathy of prematurity (ROP) is one of the main causes of blindness in children worldwide. Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), play critical protective roles in the development and function of neurons and vasculature. Lack of BDNF expre...

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Veröffentlicht in:	PloS one 2021-12, Vol.16 (12), p.e0260793-e0260793
Hauptverfasser:	Zaitoun, Ismail S, Song, Yong-Seok, Suscha, Andrew, El Ragaby, Mohamed, Sorenson, Christine M, Sheibani, Nader
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Agonists Angiogenesis Animals Animals, Newborn Apoptosis Bioflavonoids Biology and Life Sciences Blindness Blood vessels Body weight Brain-derived neurotrophic factor Cell adhesion Development and progression Diabetic retinopathy Disease Models, Animal Endothelial cells Experiments Flavones Flavones - pharmacology Flavonoids Health aspects Hyperoxia Ischemia Ischemia - chemically induced Ischemia - drug therapy Ischemia - metabolism Ischemia - pathology Kinases Laboratory animals Medical research Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Mitigation Neonates Neovascularization, Pathologic - chemically induced Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Ophthalmology Oxygen Oxygen - toxicity Pediatric research Pharmacokinetics Physical Sciences Physiological aspects Premature babies Premature birth Prevention Protein tyrosine kinase Public health Receptor, trkB - agonists Receptors Retina Retinal Neovascularization - chemically induced Retinal Neovascularization - drug therapy Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinopathy Retinopathy of Prematurity - chemically induced Retinopathy of Prematurity - drug therapy Retinopathy of Prematurity - metabolism Retinopathy of Prematurity - pathology Retrolental fibroplasia Risk factors Survival factor TrkB receptors Tropomyosin Vascular endothelial growth factor Vascularization
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