Screening for undiagnosed non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH): A population-based risk factor assessment using vibration controlled transient elastography (VCTE)

The screening for undiagnosed non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (SUNN) study was a population-based screening study that aimed to provide proof of concept to encourage community-level screening and detection for this non-communicable disease. Current screening guide...

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Veröffentlicht in:PloS one 2021-11, Vol.16 (11), p.e0260320-e0260320
Hauptverfasser: Eskridge, Wayne, Vierling, John M, Gosbee, Wayne, Wan, Gabriella A, Hyunh, May-Linh, Chang, Henry E
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creator Eskridge, Wayne
Vierling, John M
Gosbee, Wayne
Wan, Gabriella A
Hyunh, May-Linh
Chang, Henry E
description The screening for undiagnosed non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (SUNN) study was a population-based screening study that aimed to provide proof of concept to encourage community-level screening and detection for this non-communicable disease. Current screening guidelines do not recommend the routine screening of nonalcoholic fatty liver disease (NAFLD) for asymptomatic populations, so providers are not encouraged to actively seek disease, even in high-risk patients. This study sought to determine whether a self-selecting cohort of asymptomatic individuals would have scores based on vibration controlled transient elastography (VCTE) and controlled attenuation parameter (CAP) significantly correlated to risk factors to suggest that routine screening for high-risk patients should be recommended. The study recruited 1,070 self-selected participants in Houston and Galveston County, Texas, 940 of which were included in final analysis. A pre-screening survey was used to determine eligibility. VCTE-based scores analyzed steatosis and fibrosis levels. Fifty-seven percent of the study population demonstrated steatosis without fibrosis, suggesting NAFLD, while 16% demonstrated both steatosis and fibrosis, suggesting NASH. Statistically significant risk factors included factors related to metabolic syndrome, race, and age, while statistically significant protective factors included consumption of certain foods and exercise. The findings of this study suggest that high-risk individuals should be screened for NAFLD even in the absence of symptoms and that community-based screenings are an effective tool, particularly in the absence of proactive guidelines for providers.
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Current screening guidelines do not recommend the routine screening of nonalcoholic fatty liver disease (NAFLD) for asymptomatic populations, so providers are not encouraged to actively seek disease, even in high-risk patients. This study sought to determine whether a self-selecting cohort of asymptomatic individuals would have scores based on vibration controlled transient elastography (VCTE) and controlled attenuation parameter (CAP) significantly correlated to risk factors to suggest that routine screening for high-risk patients should be recommended. The study recruited 1,070 self-selected participants in Houston and Galveston County, Texas, 940 of which were included in final analysis. A pre-screening survey was used to determine eligibility. VCTE-based scores analyzed steatosis and fibrosis levels. Fifty-seven percent of the study population demonstrated steatosis without fibrosis, suggesting NAFLD, while 16% demonstrated both steatosis and fibrosis, suggesting NASH. 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subjects Adolescent
Adult
Aged
Aged, 80 and over
Alcohol
Asymptomatic
Attenuation
Biology and Life Sciences
Biopsy
Comorbidity
Diabetes
Elasticity Imaging Techniques
Fatty liver
Female
Fibrosis
Food consumption
Guidelines
Health risks
Humans
Hypertension
Lifestyles
Liver
Liver diseases
Male
Medicine and Health Sciences
Metabolic disorders
Metabolic syndrome
Middle Aged
Non-alcoholic Fatty Liver Disease - diagnostic imaging
Patients
Population
Population studies
Risk analysis
Risk Factors
Risk groups
Signs and symptoms
Statistical analysis
Steatosis
Transplants & implants
Ultrasonic imaging
Vibration
Weight control
title Screening for undiagnosed non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH): A population-based risk factor assessment using vibration controlled transient elastography (VCTE)
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