Genetic diversity and population structure of the human malaria parasite Plasmodium falciparum surface protein Pfs47 in isolates from the lowlands in Western Kenya

Plasmodium falciparum parasites have evolved genetic adaptations to overcome immune responses mounted by diverse Anopheles vectors hindering malaria control efforts. Plasmodium falciparum surface protein Pfs47 is critical in the parasite's survival by manipulating the vector's immune syste...

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Veröffentlicht in:	PloS one 2021-11, Vol.16 (11), p.e0260434-e0260434
Hauptverfasser:	Onyango, Shirley A, Ochwedo, Kevin O, Machani, Maxwell G, Omondi, Collince J, Debrah, Isaiah, Ogolla, Sidney O, Lee, Ming-Chieh, Zhou, Guofa, Kokwaro, Elizabeth, Kazura, James W, Afrane, Yaw A, Githeko, Andrew K, Zhong, Daibin, Yan, Guiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Altitude Analysis Biological diversity Biology Biology and Life Sciences Blood Cross-Sectional Studies Deoxyribonucleic acid Disease transmission DNA DNA sequencing Ecology and Environmental Sciences Erythrocytes Gene flow Gene Frequency Gene sequencing Genetic aspects Genetic diversity Genetic Variation Genotypes Haplotypes Health sciences Humans Immune response Immune system Kenya - epidemiology Lowlands Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Medical research Medicine and Health Sciences Membrane Glycoproteins - genetics Mosquitoes Mutation Nucleotide sequencing Nucleotides Parasites People and Places Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - isolation & purification Polymerase chain reaction Population Population (statistical) Population genetics Population growth Population structure Population studies Positive selection Proteins Protozoan Proteins - genetics Public health Sea level Statistical analysis Statistical methods Vector-borne diseases Vectors
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