Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin

High grade glioma is one of the deadliest human cancers with a median survival rate of only one year following diagnosis. The highly motile and invasive nature of high grade glioma makes it difficult to completely remove surgically. Therefore, increasing our knowledge of the mechanisms glioma cells...

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Veröffentlicht in:	PloS one 2021-11, Vol.16 (11), p.e0260252-e0260252
Hauptverfasser:	Coniglio, Salvatore J, Segall, Jeffrey E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiregulin Amphiregulin - genetics Amphiregulin - metabolism Animals Antibodies Biology Biology and Life Sciences Blocking antibodies Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Breast cancer Cancer invasiveness Cell culture Cell Line, Tumor Cerebrospinal fluid Development and progression Epidermal growth factor receptors ErbB Receptors - metabolism Gene Expression Regulation, Neoplastic Genomes Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma cells Gliomas Health aspects Humans Ligands Ligands (Biochemistry) Macrophage colony-stimulating factor Macrophages Mammals Medical research Medicine and Health Sciences Mice Mice, Inbred C57BL Microglia Microglia - metabolism Microglia - pathology Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Pharmacology Physiological aspects Research and Analysis Methods RNA-mediated interference Signal Transduction Signaling Survival Tumors Up-Regulation
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