Periodontitis, dental plaque, and atrial fibrillation in the Hamburg City Health Study
Atrial fibrillation (AF) is a major health problem and causes heart failure and stroke. Pathophysiological mechanisms indicate a link with oral health including periodontitis (PD), but supporting data are scarce. The aim was to investigate the link between features of oral health and the prevalence...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-11, Vol.16 (11), p.e0259652-e0259652 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0259652 |
|---|---|
| container_issue | 11 |
| container_start_page | e0259652 |
| container_title | PloS one |
| container_volume | 16 |
| creator | Struppek, Julia Schnabel, Renate B Walther, Carolin Heydecke, Guido Seedorf, Udo Lamprecht, Ragna Smeets, Ralf Borof, Katrin Zeller, Tanja Beikler, Thomas Börschel, Christin S Karakas, Mahir Gosau, Martin Aarabi, Ghazal |
| description | Atrial fibrillation (AF) is a major health problem and causes heart failure and stroke. Pathophysiological mechanisms indicate a link with oral health including periodontitis (PD), but supporting data are scarce. The aim was to investigate the link between features of oral health and the prevalence of AF.
This cross-sectional analysis of the Hamburg City Health Study included 5,634 participants with complete data on their PD and AF status. AF was assessed via self-reported questionnaire or medically diagnosed by standard 12-lead resting ECG. The oral health examination included full-mouth measurements of the dental plaque index (PI), the clinical attachment loss (CAL) at 6 sites per tooth, the bleeding on probing (BOP) and the decayed, missing and filled teeth (DMFT) index. Descriptive analyses for all variables stratified by the status of PD were performed. To test for an association between prevalent PD and prevalent AF, multivariable logistic regression models were used. Mediation analysis was used to test if interleukin-6 (IL-6) and/or C-reactive protein (CRP) mediated the association between PD and AF.
Atrial fibrillation (prevalence: 5.6%) and the severity of PD (prevalence: moderate: 57.7%, severe: 18.9%) increased with age in men and women. Prevalent severe PD, CAL ≥3 mm, PI, and BOP were all associated with prevalent AF in unadjusted regression analysis. However, no association except for PI (odds ratio (OR): 1.22, 95% confidence interval (CI): 1.1-1.35, p |
| doi_str_mv | 10.1371/journal.pone.0259652 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2601116240</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A683450987</galeid><doaj_id>oai_doaj_org_article_7345b50c16684697aa15706d63c2bc52</doaj_id><sourcerecordid>A683450987</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-1dfa4d9b4ef11bcf85400d04a37c6dd77012d7947a070aa96c9be2364651b83d3</originalsourceid><addsrcrecordid>eNqNklFv0zAUhSMEYmPwDxBEQkIgrcWOHTt5QZoqoJUmDTHYq3VjO60nN-5sB9F_j9tmU4P2gPLg6Pq7x77HJ8teYzTFhONPt673HdjpxnV6ioqyZmXxJDvFNSkmrEDk6dH_SfYihFuESlIx9jw7IbRCvCblaXbzXXvjlOuiiSac50p3EWy-sXDX6_McOpVD9CaVWtN4Yy1E47rcdHlc6XwO66b3y3xm4jafa7BxlV_HXm1fZs9asEG_Gtaz7NfXLz9n88nl1bfF7OJyIlldxAlWLVBVN1S3GDeyrUqKkEIUCJdMKc4RLhSvKQfEEUDNZN3ogjDKStxURJGz7O1Bd2NdEIMlQRQMYYxZQVEiFgdCObgVG2_W4LfCgRH7gvNLAT4aabXghJZNiSRmrKKs5gC45IgpRmTRyLJIWp-H0_pmrZVMXnmwI9HxTmdWYul-i4qhiiCWBD4MAt4lf0MUaxOkTq522vWHe6enwXv03T_o49MN1BLSAKZrXTpX7kTFBavSPKiueKKmj1DpU3ptZMpPa1J91PBx1JCYqP_EJfQhiMX1j_9nr27G7PsjdrUPTHC232UqjEF6AKV3IXjdPpiMkdjF_94NsYu_GOKf2t4cP9BD033eyV-NQv32</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2601116240</pqid></control><display><type>article</type><title>Periodontitis, dental plaque, and atrial fibrillation in the Hamburg City Health Study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Struppek, Julia ; Schnabel, Renate B ; Walther, Carolin ; Heydecke, Guido ; Seedorf, Udo ; Lamprecht, Ragna ; Smeets, Ralf ; Borof, Katrin ; Zeller, Tanja ; Beikler, Thomas ; Börschel, Christin S ; Karakas, Mahir ; Gosau, Martin ; Aarabi, Ghazal</creator><contributor>Ai, Tomohiko</contributor><creatorcontrib>Struppek, Julia ; Schnabel, Renate B ; Walther, Carolin ; Heydecke, Guido ; Seedorf, Udo ; Lamprecht, Ragna ; Smeets, Ralf ; Borof, Katrin ; Zeller, Tanja ; Beikler, Thomas ; Börschel, Christin S ; Karakas, Mahir ; Gosau, Martin ; Aarabi, Ghazal ; Ai, Tomohiko</creatorcontrib><description>Atrial fibrillation (AF) is a major health problem and causes heart failure and stroke. Pathophysiological mechanisms indicate a link with oral health including periodontitis (PD), but supporting data are scarce. The aim was to investigate the link between features of oral health and the prevalence of AF.
This cross-sectional analysis of the Hamburg City Health Study included 5,634 participants with complete data on their PD and AF status. AF was assessed via self-reported questionnaire or medically diagnosed by standard 12-lead resting ECG. The oral health examination included full-mouth measurements of the dental plaque index (PI), the clinical attachment loss (CAL) at 6 sites per tooth, the bleeding on probing (BOP) and the decayed, missing and filled teeth (DMFT) index. Descriptive analyses for all variables stratified by the status of PD were performed. To test for an association between prevalent PD and prevalent AF, multivariable logistic regression models were used. Mediation analysis was used to test if interleukin-6 (IL-6) and/or C-reactive protein (CRP) mediated the association between PD and AF.
Atrial fibrillation (prevalence: 5.6%) and the severity of PD (prevalence: moderate: 57.7%, severe: 18.9%) increased with age in men and women. Prevalent severe PD, CAL ≥3 mm, PI, and BOP were all associated with prevalent AF in unadjusted regression analysis. However, no association except for PI (odds ratio (OR): 1.22, 95% confidence interval (CI): 1.1-1.35, p<0.001) could be observed after adjusting for age, sex, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), body mass index, diabetes, smoking, and educational level. Participants brushing their teeth at least twice daily had a lower AF prevalence compared with those brushing only once daily. Hs-CRP, IL-6, and the odds of AF increased as a function of PD severity grades in unadjusted analysis. However, neither the DMFT index nor IL-6 or CRP was associated with AF after adjusting for age and sex. Mediation analyses could not provide support for the hypothesis that IL-6 or CRP acted as mediator of the association between prevalent PD and prevalent AF.
The study shows an association between prevalent AF and increased dental plaque levels indicated by a higher PI. In contrast, an association of prevalent PD with prevalent AF after adjustments for several confounders could not be demonstrated. Further studies are necessary to investigate the mechanisms underlying poor oral hygiene and AF as well as the influence of improved oral hygiene on AF onset.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0259652</identifier><identifier>PMID: 34807935</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Atrial fibrillation ; Atrial Fibrillation - blood ; Atrial Fibrillation - pathology ; Biology and Life Sciences ; Biomarkers - blood ; Body mass ; Body mass index ; Body size ; Brushing ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiac arrhythmia ; Cardiology ; Confidence intervals ; Congestive heart failure ; Cross-Sectional Studies ; Dental plaque ; Dental Plaque - blood ; Dental Plaque - pathology ; Dentistry ; Dentists ; Diabetes ; Diabetes mellitus ; Disease prevention ; EKG ; Endocarditis ; Epidemiology ; Female ; Fibrillation ; Gum disease ; Heart ; Humans ; Hygiene ; Inflammation ; Interleukin 6 ; Interleukin-6 - blood ; Logistic Models ; Male ; Maxillofacial surgery ; Medicine ; Medicine and Health Sciences ; Men ; Middle Aged ; Oral hygiene ; Periodontitis ; Periodontitis - blood ; Periodontitis - pathology ; Plaque index ; Prostheses ; Proteins ; Regression analysis ; Regression models ; Research and Analysis Methods ; Risk factors ; Sex ; Statistical analysis ; Statistics ; Stroke ; Teeth ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2021-11, Vol.16 (11), p.e0259652-e0259652</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Struppek et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Struppek et al 2021 Struppek et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1dfa4d9b4ef11bcf85400d04a37c6dd77012d7947a070aa96c9be2364651b83d3</citedby><cites>FETCH-LOGICAL-c692t-1dfa4d9b4ef11bcf85400d04a37c6dd77012d7947a070aa96c9be2364651b83d3</cites><orcidid>0000-0003-4652-5358</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608306/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608306/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34807935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ai, Tomohiko</contributor><creatorcontrib>Struppek, Julia</creatorcontrib><creatorcontrib>Schnabel, Renate B</creatorcontrib><creatorcontrib>Walther, Carolin</creatorcontrib><creatorcontrib>Heydecke, Guido</creatorcontrib><creatorcontrib>Seedorf, Udo</creatorcontrib><creatorcontrib>Lamprecht, Ragna</creatorcontrib><creatorcontrib>Smeets, Ralf</creatorcontrib><creatorcontrib>Borof, Katrin</creatorcontrib><creatorcontrib>Zeller, Tanja</creatorcontrib><creatorcontrib>Beikler, Thomas</creatorcontrib><creatorcontrib>Börschel, Christin S</creatorcontrib><creatorcontrib>Karakas, Mahir</creatorcontrib><creatorcontrib>Gosau, Martin</creatorcontrib><creatorcontrib>Aarabi, Ghazal</creatorcontrib><title>Periodontitis, dental plaque, and atrial fibrillation in the Hamburg City Health Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Atrial fibrillation (AF) is a major health problem and causes heart failure and stroke. Pathophysiological mechanisms indicate a link with oral health including periodontitis (PD), but supporting data are scarce. The aim was to investigate the link between features of oral health and the prevalence of AF.
This cross-sectional analysis of the Hamburg City Health Study included 5,634 participants with complete data on their PD and AF status. AF was assessed via self-reported questionnaire or medically diagnosed by standard 12-lead resting ECG. The oral health examination included full-mouth measurements of the dental plaque index (PI), the clinical attachment loss (CAL) at 6 sites per tooth, the bleeding on probing (BOP) and the decayed, missing and filled teeth (DMFT) index. Descriptive analyses for all variables stratified by the status of PD were performed. To test for an association between prevalent PD and prevalent AF, multivariable logistic regression models were used. Mediation analysis was used to test if interleukin-6 (IL-6) and/or C-reactive protein (CRP) mediated the association between PD and AF.
Atrial fibrillation (prevalence: 5.6%) and the severity of PD (prevalence: moderate: 57.7%, severe: 18.9%) increased with age in men and women. Prevalent severe PD, CAL ≥3 mm, PI, and BOP were all associated with prevalent AF in unadjusted regression analysis. However, no association except for PI (odds ratio (OR): 1.22, 95% confidence interval (CI): 1.1-1.35, p<0.001) could be observed after adjusting for age, sex, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), body mass index, diabetes, smoking, and educational level. Participants brushing their teeth at least twice daily had a lower AF prevalence compared with those brushing only once daily. Hs-CRP, IL-6, and the odds of AF increased as a function of PD severity grades in unadjusted analysis. However, neither the DMFT index nor IL-6 or CRP was associated with AF after adjusting for age and sex. Mediation analyses could not provide support for the hypothesis that IL-6 or CRP acted as mediator of the association between prevalent PD and prevalent AF.
The study shows an association between prevalent AF and increased dental plaque levels indicated by a higher PI. In contrast, an association of prevalent PD with prevalent AF after adjustments for several confounders could not be demonstrated. Further studies are necessary to investigate the mechanisms underlying poor oral hygiene and AF as well as the influence of improved oral hygiene on AF onset.</description><subject>Age</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - blood</subject><subject>Atrial Fibrillation - pathology</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - blood</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Brushing</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Confidence intervals</subject><subject>Congestive heart failure</subject><subject>Cross-Sectional Studies</subject><subject>Dental plaque</subject><subject>Dental Plaque - blood</subject><subject>Dental Plaque - pathology</subject><subject>Dentistry</subject><subject>Dentists</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Disease prevention</subject><subject>EKG</subject><subject>Endocarditis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Gum disease</subject><subject>Heart</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Maxillofacial surgery</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Oral hygiene</subject><subject>Periodontitis</subject><subject>Periodontitis - blood</subject><subject>Periodontitis - pathology</subject><subject>Plaque index</subject><subject>Prostheses</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Sex</subject><subject>Statistical analysis</subject><subject>Statistics</subject><subject>Stroke</subject><subject>Teeth</subject><subject>Tumor necrosis factor-TNF</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNklFv0zAUhSMEYmPwDxBEQkIgrcWOHTt5QZoqoJUmDTHYq3VjO60nN-5sB9F_j9tmU4P2gPLg6Pq7x77HJ8teYzTFhONPt673HdjpxnV6ioqyZmXxJDvFNSkmrEDk6dH_SfYihFuESlIx9jw7IbRCvCblaXbzXXvjlOuiiSac50p3EWy-sXDX6_McOpVD9CaVWtN4Yy1E47rcdHlc6XwO66b3y3xm4jafa7BxlV_HXm1fZs9asEG_Gtaz7NfXLz9n88nl1bfF7OJyIlldxAlWLVBVN1S3GDeyrUqKkEIUCJdMKc4RLhSvKQfEEUDNZN3ogjDKStxURJGz7O1Bd2NdEIMlQRQMYYxZQVEiFgdCObgVG2_W4LfCgRH7gvNLAT4aabXghJZNiSRmrKKs5gC45IgpRmTRyLJIWp-H0_pmrZVMXnmwI9HxTmdWYul-i4qhiiCWBD4MAt4lf0MUaxOkTq522vWHe6enwXv03T_o49MN1BLSAKZrXTpX7kTFBavSPKiueKKmj1DpU3ptZMpPa1J91PBx1JCYqP_EJfQhiMX1j_9nr27G7PsjdrUPTHC232UqjEF6AKV3IXjdPpiMkdjF_94NsYu_GOKf2t4cP9BD033eyV-NQv32</recordid><startdate>20211122</startdate><enddate>20211122</enddate><creator>Struppek, Julia</creator><creator>Schnabel, Renate B</creator><creator>Walther, Carolin</creator><creator>Heydecke, Guido</creator><creator>Seedorf, Udo</creator><creator>Lamprecht, Ragna</creator><creator>Smeets, Ralf</creator><creator>Borof, Katrin</creator><creator>Zeller, Tanja</creator><creator>Beikler, Thomas</creator><creator>Börschel, Christin S</creator><creator>Karakas, Mahir</creator><creator>Gosau, Martin</creator><creator>Aarabi, Ghazal</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4652-5358</orcidid></search><sort><creationdate>20211122</creationdate><title>Periodontitis, dental plaque, and atrial fibrillation in the Hamburg City Health Study</title><author>Struppek, Julia ; Schnabel, Renate B ; Walther, Carolin ; Heydecke, Guido ; Seedorf, Udo ; Lamprecht, Ragna ; Smeets, Ralf ; Borof, Katrin ; Zeller, Tanja ; Beikler, Thomas ; Börschel, Christin S ; Karakas, Mahir ; Gosau, Martin ; Aarabi, Ghazal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1dfa4d9b4ef11bcf85400d04a37c6dd77012d7947a070aa96c9be2364651b83d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - blood</topic><topic>Atrial Fibrillation - pathology</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - blood</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Brushing</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Confidence intervals</topic><topic>Congestive heart failure</topic><topic>Cross-Sectional Studies</topic><topic>Dental plaque</topic><topic>Dental Plaque - blood</topic><topic>Dental Plaque - pathology</topic><topic>Dentistry</topic><topic>Dentists</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Disease prevention</topic><topic>EKG</topic><topic>Endocarditis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fibrillation</topic><topic>Gum disease</topic><topic>Heart</topic><topic>Humans</topic><topic>Hygiene</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Maxillofacial surgery</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Oral hygiene</topic><topic>Periodontitis</topic><topic>Periodontitis - blood</topic><topic>Periodontitis - pathology</topic><topic>Plaque index</topic><topic>Prostheses</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Research and Analysis Methods</topic><topic>Risk factors</topic><topic>Sex</topic><topic>Statistical analysis</topic><topic>Statistics</topic><topic>Stroke</topic><topic>Teeth</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Struppek, Julia</creatorcontrib><creatorcontrib>Schnabel, Renate B</creatorcontrib><creatorcontrib>Walther, Carolin</creatorcontrib><creatorcontrib>Heydecke, Guido</creatorcontrib><creatorcontrib>Seedorf, Udo</creatorcontrib><creatorcontrib>Lamprecht, Ragna</creatorcontrib><creatorcontrib>Smeets, Ralf</creatorcontrib><creatorcontrib>Borof, Katrin</creatorcontrib><creatorcontrib>Zeller, Tanja</creatorcontrib><creatorcontrib>Beikler, Thomas</creatorcontrib><creatorcontrib>Börschel, Christin S</creatorcontrib><creatorcontrib>Karakas, Mahir</creatorcontrib><creatorcontrib>Gosau, Martin</creatorcontrib><creatorcontrib>Aarabi, Ghazal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Struppek, Julia</au><au>Schnabel, Renate B</au><au>Walther, Carolin</au><au>Heydecke, Guido</au><au>Seedorf, Udo</au><au>Lamprecht, Ragna</au><au>Smeets, Ralf</au><au>Borof, Katrin</au><au>Zeller, Tanja</au><au>Beikler, Thomas</au><au>Börschel, Christin S</au><au>Karakas, Mahir</au><au>Gosau, Martin</au><au>Aarabi, Ghazal</au><au>Ai, Tomohiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodontitis, dental plaque, and atrial fibrillation in the Hamburg City Health Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-11-22</date><risdate>2021</risdate><volume>16</volume><issue>11</issue><spage>e0259652</spage><epage>e0259652</epage><pages>e0259652-e0259652</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Atrial fibrillation (AF) is a major health problem and causes heart failure and stroke. Pathophysiological mechanisms indicate a link with oral health including periodontitis (PD), but supporting data are scarce. The aim was to investigate the link between features of oral health and the prevalence of AF.
This cross-sectional analysis of the Hamburg City Health Study included 5,634 participants with complete data on their PD and AF status. AF was assessed via self-reported questionnaire or medically diagnosed by standard 12-lead resting ECG. The oral health examination included full-mouth measurements of the dental plaque index (PI), the clinical attachment loss (CAL) at 6 sites per tooth, the bleeding on probing (BOP) and the decayed, missing and filled teeth (DMFT) index. Descriptive analyses for all variables stratified by the status of PD were performed. To test for an association between prevalent PD and prevalent AF, multivariable logistic regression models were used. Mediation analysis was used to test if interleukin-6 (IL-6) and/or C-reactive protein (CRP) mediated the association between PD and AF.
Atrial fibrillation (prevalence: 5.6%) and the severity of PD (prevalence: moderate: 57.7%, severe: 18.9%) increased with age in men and women. Prevalent severe PD, CAL ≥3 mm, PI, and BOP were all associated with prevalent AF in unadjusted regression analysis. However, no association except for PI (odds ratio (OR): 1.22, 95% confidence interval (CI): 1.1-1.35, p<0.001) could be observed after adjusting for age, sex, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), body mass index, diabetes, smoking, and educational level. Participants brushing their teeth at least twice daily had a lower AF prevalence compared with those brushing only once daily. Hs-CRP, IL-6, and the odds of AF increased as a function of PD severity grades in unadjusted analysis. However, neither the DMFT index nor IL-6 or CRP was associated with AF after adjusting for age and sex. Mediation analyses could not provide support for the hypothesis that IL-6 or CRP acted as mediator of the association between prevalent PD and prevalent AF.
The study shows an association between prevalent AF and increased dental plaque levels indicated by a higher PI. In contrast, an association of prevalent PD with prevalent AF after adjustments for several confounders could not be demonstrated. Further studies are necessary to investigate the mechanisms underlying poor oral hygiene and AF as well as the influence of improved oral hygiene on AF onset.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34807935</pmid><doi>10.1371/journal.pone.0259652</doi><tpages>e0259652</tpages><orcidid>https://orcid.org/0000-0003-4652-5358</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-11, Vol.16 (11), p.e0259652-e0259652 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2601116240 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Atrial fibrillation Atrial Fibrillation - blood Atrial Fibrillation - pathology Biology and Life Sciences Biomarkers - blood Body mass Body mass index Body size Brushing C-reactive protein C-Reactive Protein - metabolism Cardiac arrhythmia Cardiology Confidence intervals Congestive heart failure Cross-Sectional Studies Dental plaque Dental Plaque - blood Dental Plaque - pathology Dentistry Dentists Diabetes Diabetes mellitus Disease prevention EKG Endocarditis Epidemiology Female Fibrillation Gum disease Heart Humans Hygiene Inflammation Interleukin 6 Interleukin-6 - blood Logistic Models Male Maxillofacial surgery Medicine Medicine and Health Sciences Men Middle Aged Oral hygiene Periodontitis Periodontitis - blood Periodontitis - pathology Plaque index Prostheses Proteins Regression analysis Regression models Research and Analysis Methods Risk factors Sex Statistical analysis Statistics Stroke Teeth Tumor necrosis factor-TNF |
| title | Periodontitis, dental plaque, and atrial fibrillation in the Hamburg City Health Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T09%3A41%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Periodontitis,%20dental%20plaque,%20and%20atrial%20fibrillation%20in%20the%20Hamburg%20City%20Health%20Study&rft.jtitle=PloS%20one&rft.au=Struppek,%20Julia&rft.date=2021-11-22&rft.volume=16&rft.issue=11&rft.spage=e0259652&rft.epage=e0259652&rft.pages=e0259652-e0259652&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0259652&rft_dat=%3Cgale_plos_%3EA683450987%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2601116240&rft_id=info:pmid/34807935&rft_galeid=A683450987&rft_doaj_id=oai_doaj_org_article_7345b50c16684697aa15706d63c2bc52&rfr_iscdi=true |