Perturbation of BRMS1 interactome reveals pathways that impact metastasis

Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic development. In this study, we confirmed that the...

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Veröffentlicht in:	PloS one 2021-11, Vol.16 (11), p.e0259128
Hauptverfasser:	Zimmermann, Rosalyn C, Sardiu, Mihaela E, Manton, Christa A, Miah, Md Sayem, Banks, Charles A S, Adams, Mark K, Koestler, Devin C, Hurst, Douglas R, Edmonds, Mick D, Washburn, Michael P, Welch, Danny R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biological activity Biology Biology and Life Sciences BRCA1 protein Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology C-Terminus Cancer Cell cycle Cell Line, Tumor Cell Movement Data science Deoxyribonucleic acid Development and progression DNA DNA repair Epigenetics Female Funding Genetic aspects Histone deacetylase Humans Interactomes Kinases Medical research Medicine and Health Sciences Metastases Metastasis Mice Neoplasm Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncology, Experimental Perturbation Phenotypes Phosphorylation Protein Binding Protein interaction Protein Interaction Maps Protein-protein interactions Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Research and analysis methods Sin3 Histone Deacetylase and Corepressor Complex - genetics Sin3 Histone Deacetylase and Corepressor Complex - metabolism Supervision
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