Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful mixed-effects differential equations framework to analyze da...

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Veröffentlicht in:	PLoS computational biology 2021-10, Vol.17 (10), p.e1009468
Hauptverfasser:	Zarnitsyna, Veronika I, Akondy, Rama S, Ahmed, Hasan, McGuire, Donald J, Zarnitsyn, Vladimir G, Moore, Mia, Johnson, Philip L F, Ahmed, Rafi, Li, Kelvin W, Hellerstein, Marc K, Antia, Rustom
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell culture Cell death Cell division Computational Biology Deuterium Differential equations Epidemic models Epidemiology Fever Health aspects Humans Immunologic Memory - immunology Immunological memory Immunology Infections Labeling Low level Lymphocytes Lymphocytes T Medicine and Health Sciences Memory cells Models, Immunological Pathogens Physical Sciences Physiological aspects Population Prevention Research and Analysis Methods T cells Vaccination Vaccines Vector-borne diseases Viral infections Viral vaccines Viruses Yellow fever Yellow Fever Vaccine - immunology Yellow fever virus - immunology
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