The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages
Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacteriu...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2021-10, Vol.15 (10), p.e0009832-e0009832 |
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| creator | Mikaty, Guillain Coullon, Héloïse Fiette, Laurence Pizarro-Cerdá, Javier Carniel, Elisabeth |
| description | Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacterium to cross and disrupt the endothelial vascular barrier remain poorly understood. In this study, an innovative model of in vivo infection was used to focus on the interaction between Y. pestis and its host vascular system. In the draining lymph nodes and in secondary organs, bacteria provoked the porosity and disruption of blood vessels. An in vitro model of endothelial barrier showed a role in this phenotype for the pYV/pCD1 plasmid that carries a Type Three Secretion System. This work supports that the pYV/pCD1 plasmid is responsible for the powerful tissue invasiveness capacity of the plague bacillus and the hemorrhagic features of plague. |
| doi_str_mv | 10.1371/journal.pntd.0009832 |
| format | Article |
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This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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complications</topic><topic>Plague - microbiology</topic><topic>Plasmids</topic><topic>Plasmids - genetics</topic><topic>Plasmids - metabolism</topic><topic>Porosity</topic><topic>Research and Analysis Methods</topic><topic>Secretion</topic><topic>Tropical diseases</topic><topic>Vascular system</topic><topic>Virulence</topic><topic>Yersinia infections</topic><topic>Yersinia pestis</topic><topic>Yersinia pestis - genetics</topic><topic>Yersinia pestis - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mikaty, Guillain</creatorcontrib><creatorcontrib>Coullon, Héloïse</creatorcontrib><creatorcontrib>Fiette, Laurence</creatorcontrib><creatorcontrib>Pizarro-Cerdá, Javier</creatorcontrib><creatorcontrib>Carniel, Elisabeth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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In this study, an innovative model of in vivo infection was used to focus on the interaction between Y. pestis and its host vascular system. In the draining lymph nodes and in secondary organs, bacteria provoked the porosity and disruption of blood vessels. An in vitro model of endothelial barrier showed a role in this phenotype for the pYV/pCD1 plasmid that carries a Type Three Secretion System. This work supports that the pYV/pCD1 plasmid is responsible for the powerful tissue invasiveness capacity of the plague bacillus and the hemorrhagic features of plague.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34610007</pmid><doi>10.1371/journal.pntd.0009832</doi><orcidid>https://orcid.org/0000-0002-6758-2514</orcidid><orcidid>https://orcid.org/0000-0002-4582-0585</orcidid><orcidid>https://orcid.org/0000-0002-4343-0508</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PLoS neglected tropical diseases, 2021-10, Vol.15 (10), p.e0009832-e0009832 |
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| source | PubMed (Medline); MEDLINE; Public Library of Science; DOAJ Directory of Open Access Journals; Free E-Journal (出版社公開部分のみ）; PubMed Central Open Access |
| subjects | Animal genetics Animals Bacteria Bacteriology Biology and Life Sciences Blood Blood vessels Blood Vessels - microbiology Body organs Cell Behavior Cellular Biology Circulatory system Complications and side effects Development and progression Drainage systems Experiments Genes Genetics Haemorrhage Hemorrhage Hemorrhage - etiology Hemorrhage - microbiology Host-bacteria relationships Human health and pathology Humans Immune system In vivo methods and tests Infections Infectious diseases Invasiveness Laboratories Life Sciences Lymph Lymph nodes Lymphatic system Medicine and Health Sciences Mice Microbiology and Parasitology Organs Pathogenesis Pathogens Permeability Phenotypes Physiological aspects Plague Plague - complications Plague - microbiology Plasmids Plasmids - genetics Plasmids - metabolism Porosity Research and Analysis Methods Secretion Tropical diseases Vascular system Virulence Yersinia infections Yersinia pestis Yersinia pestis - genetics Yersinia pestis - physiology |
| title | The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages |
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