Bile acid-independent protection against Clostridioides difficile infection

Clostridioides difficile infections occur upon ecological / metabolic disruptions to the normal colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids through a 7α-dehydroxylation pathway found in select members of the healthy microbiota is regarded to be the pro...

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Veröffentlicht in:	PLoS pathogens 2021-10, Vol.17 (10), p.e1010015-e1010015
Hauptverfasser:	Aguirre, Andrea Martinez, Yalcinkaya, Nazli, Wu, Qinglong, Swennes, Alton, Tessier, Mary Elizabeth, Roberts, Paul, Miyajima, Fabio, Savidge, Tor, Sorg, Joseph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid production Acids Amino acids Animals Antibiotics Bacteria Bile Bile acid metabolism Bile acids Bile Acids and Salts - metabolism Biology and Life Sciences Biomarkers Cholesterol Cholic acid Clostridioides difficile Clostridium infections Clostridium Infections - metabolism Development and progression Disease Resistance - physiology Gastrointestinal Microbiome - physiology Germfree Health aspects Infections Liver Medicine and Health Sciences Metabolism Mice Mice, Knockout Microbiomes Microbiota Microbiota (Symbiotic organisms) Nutrients Physical Sciences Prevention Research and Analysis Methods Spores
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