A 6-CpG validated methylation risk score model for metabolic syndrome: The HyperGEN and GOLDN studies

There has been great interest in genetic risk prediction using risk scores in recent years, however, the utility of scores developed in European populations and later applied to non-European populations has not been successful. The goal of this study was to create a methylation risk score (MRS) for...

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Veröffentlicht in:	PloS one 2021-11, Vol.16 (11), p.e0259836-e0259836
Hauptverfasser:	Hidalgo, Bertha A, Minniefield, Bre, Patki, Amit, Tanner, Rikki, Bagheri, Minoo, Tiwari, Hemant K, Arnett, Donna K, Irvin, Marguerite Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Algorithms Analysis Biology and life sciences Black or African American - genetics Blood pressure Complications CpG Islands Cross-Sectional Studies Cytokines Cytosine Demographic aspects Diabetes Diagnosis Disease DNA Methylation Epidemiology Epigenesis, Genetic Estimates Fasting Female Genetic aspects Genetic Association Studies - methods Genetic Markers Genetic testing Genetics Glucose Guanine Health risk assessment Health risks High density lipoprotein Humans Hypertension Lipids Logistic Models Male Medicine and Health Sciences Metabolic disorders Metabolic syndrome Metabolic Syndrome - ethnology Metabolic Syndrome - genetics Metabolic syndrome X Methylation Middle Aged Minority & ethnic groups Parameter estimation Populations Public health Race Risk Risk factors Triglycerides Validation studies White People - genetics
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