Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia
Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and geneti...
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| Veröffentlicht in: | PloS one 2021-11, Vol.16 (11), p.e0257895 |
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| creator | Al-Amer, Osama M Oyouni, Atif Abdulwahab A Alshehri, Mohammed Ali Alasmari, Abdulrahman Alzahrani, Othman R Aljohani, Saad Ali S Alasmael, Noura Theyab, Abdulrahman Algahtani, Mohammad Al Sadoun, Hadeel Alsharif, Khalaf F Hamad, Abdullah Abdali, Wed A Hawasawi, Yousef MohammedRabaa |
| description | Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin.
The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.
A cohort of 108 female university students aged 18-25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3-5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR.
The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P |
| doi_str_mv | 10.1371/journal.pone.0257895 |
| format | Article |
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The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.
A cohort of 108 female university students aged 18-25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3-5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR.
The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P<0.001) associated with dominant genotypes (TC+CC) and increased risk of IDA while BMP2 rs235756 is significantly (P<0.026) associated with recessive homozygote CC genotypes and increased risk of IDA.
Our finding potentially helps in the early prediction of iron deficiency in females through the genetic testing.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0257895</identifier><identifier>PMID: 34780475</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Alleles ; Analysis ; Anemia ; Anemia, Iron-Deficiency - epidemiology ; Anemia, Iron-Deficiency - genetics ; Biology ; Biology and Life Sciences ; Biotechnology ; Bone morphogenetic protein 2 ; Bone Morphogenetic Protein 2 - genetics ; Case-Control Studies ; Cohort Studies ; Female ; Females ; Ferritin ; Genes ; Genetic aspects ; Genetic factors ; Genetic screening ; Genetic Testing - methods ; Genomes ; Genotype ; Genotypes ; Genotyping ; Health risk assessment ; Health risks ; Hospitals ; Humans ; Iron ; Iron deficiency ; Iron deficiency anemia ; Medical laboratories ; Medicine ; Medicine and Health Sciences ; Membrane Proteins - genetics ; Nutrient deficiency ; Polymorphism, Single Nucleotide ; Risk Factors ; Saudi Arabia - epidemiology ; Serine Endopeptidases - genetics ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Students ; Universities ; Young Adult</subject><ispartof>PloS one, 2021-11, Vol.16 (11), p.e0257895</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Al-Amer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Al-Amer et al 2021 Al-Amer et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b76a88acd8bc3433d18181ac3fc8824f2eb5b10508e63a832cb98bd1cb9543e03</citedby><cites>FETCH-LOGICAL-c692t-b76a88acd8bc3433d18181ac3fc8824f2eb5b10508e63a832cb98bd1cb9543e03</cites><orcidid>0000-0001-8762-4999 ; 0000-0002-0188-1634 ; 0000-0002-6152-7709 ; 0000-0003-1901-697X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592490/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592490/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34780475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ciccacci, Cinzia</contributor><creatorcontrib>Al-Amer, Osama M</creatorcontrib><creatorcontrib>Oyouni, Atif Abdulwahab A</creatorcontrib><creatorcontrib>Alshehri, Mohammed Ali</creatorcontrib><creatorcontrib>Alasmari, Abdulrahman</creatorcontrib><creatorcontrib>Alzahrani, Othman R</creatorcontrib><creatorcontrib>Aljohani, Saad Ali S</creatorcontrib><creatorcontrib>Alasmael, Noura</creatorcontrib><creatorcontrib>Theyab, Abdulrahman</creatorcontrib><creatorcontrib>Algahtani, Mohammad</creatorcontrib><creatorcontrib>Al Sadoun, Hadeel</creatorcontrib><creatorcontrib>Alsharif, Khalaf F</creatorcontrib><creatorcontrib>Hamad, Abdullah</creatorcontrib><creatorcontrib>Abdali, Wed A</creatorcontrib><creatorcontrib>Hawasawi, Yousef MohammedRabaa</creatorcontrib><title>Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin.
The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.
A cohort of 108 female university students aged 18-25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3-5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR.
The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P<0.001) associated with dominant genotypes (TC+CC) and increased risk of IDA while BMP2 rs235756 is significantly (P<0.026) associated with recessive homozygote CC genotypes and increased risk of IDA.
Our finding potentially helps in the early prediction of iron deficiency in females through the genetic testing.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Anemia</subject><subject>Anemia, Iron-Deficiency - epidemiology</subject><subject>Anemia, Iron-Deficiency - genetics</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Biotechnology</subject><subject>Bone morphogenetic protein 2</subject><subject>Bone Morphogenetic Protein 2 - genetics</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Females</subject><subject>Ferritin</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic factors</subject><subject>Genetic screening</subject><subject>Genetic Testing - methods</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Genotyping</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron deficiency</subject><subject>Iron deficiency anemia</subject><subject>Medical laboratories</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Nutrient deficiency</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Saudi Arabia - epidemiology</subject><subject>Serine Endopeptidases - genetics</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Students</subject><subject>Universities</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkJw0eKP2HFukMrER6WNVcvgDlknjtO6Su0SO8D-Pe6aTQ3aBfKFLft5Xx8fn5MkzzGaYprjd2vXdxba6dZZPUWE5aJgD5JjXFAy4QTRhwfro-SJ92uEGBWcP06OaJYLlOXsOPkx894pA8E4m7omLb8ufPrbhJWx6dX54rIseQq2Tj-cL0i61FbvT1PTRb7WjVFGW3Wd-gCh92lUldDXJp11UBl4mjxqoPX62TCfJN8-fbw6_TI5u_g8P52dTRQvSJhUOQchQNWiUjSjtMYiDlC0UUKQrCG6YhVGDAnNKQhKVFWIqsZxYhnViJ4kL_e-29Z5OWTGS8IKgWhW5DwS8z1RO1jLbWc20F1LB0bebLhuKaELRrVacsQwQwg3dcMyjAlkUHBMdMZqELyqotf74ba-2uhaaRs6aEem4xNrVnLpfknBCpIVu3DfDAad-9lrH-TGeKXbFqx2_RB3zsRN3K_-Qe9_3UAtIT7A2MbFe9XOVM64iLWBEaWRmt5DxVHrjVGxjBoT90eCtyNBZIL-E5bQey_n5eX_sxffx-zrA3aloQ0r79p-V4R-DGZ7UHXO-043d0nGSO664DYbctcFcuiCKHtx-EF3otuyp38Bjtr_mQ</recordid><startdate>20211115</startdate><enddate>20211115</enddate><creator>Al-Amer, Osama M</creator><creator>Oyouni, Atif Abdulwahab A</creator><creator>Alshehri, Mohammed Ali</creator><creator>Alasmari, Abdulrahman</creator><creator>Alzahrani, Othman R</creator><creator>Aljohani, Saad Ali S</creator><creator>Alasmael, Noura</creator><creator>Theyab, Abdulrahman</creator><creator>Algahtani, Mohammad</creator><creator>Al Sadoun, Hadeel</creator><creator>Alsharif, Khalaf F</creator><creator>Hamad, Abdullah</creator><creator>Abdali, Wed A</creator><creator>Hawasawi, Yousef MohammedRabaa</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8762-4999</orcidid><orcidid>https://orcid.org/0000-0002-0188-1634</orcidid><orcidid>https://orcid.org/0000-0002-6152-7709</orcidid><orcidid>https://orcid.org/0000-0003-1901-697X</orcidid></search><sort><creationdate>20211115</creationdate><title>Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia</title><author>Al-Amer, Osama M ; Oyouni, Atif Abdulwahab A ; Alshehri, Mohammed Ali ; Alasmari, Abdulrahman ; Alzahrani, Othman R ; Aljohani, Saad Ali S ; Alasmael, Noura ; Theyab, Abdulrahman ; Algahtani, Mohammad ; Al Sadoun, Hadeel ; Alsharif, Khalaf F ; Hamad, Abdullah ; Abdali, Wed A ; Hawasawi, Yousef MohammedRabaa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b76a88acd8bc3433d18181ac3fc8824f2eb5b10508e63a832cb98bd1cb9543e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Analysis</topic><topic>Anemia</topic><topic>Anemia, Iron-Deficiency - epidemiology</topic><topic>Anemia, Iron-Deficiency - genetics</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Biotechnology</topic><topic>Bone morphogenetic protein 2</topic><topic>Bone Morphogenetic Protein 2 - genetics</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Females</topic><topic>Ferritin</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic factors</topic><topic>Genetic screening</topic><topic>Genetic Testing - methods</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Genotyping</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Iron</topic><topic>Iron deficiency</topic><topic>Iron deficiency anemia</topic><topic>Medical laboratories</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Nutrient deficiency</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Saudi Arabia - epidemiology</topic><topic>Serine Endopeptidases - genetics</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Students</topic><topic>Universities</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Amer, Osama M</creatorcontrib><creatorcontrib>Oyouni, Atif Abdulwahab A</creatorcontrib><creatorcontrib>Alshehri, Mohammed Ali</creatorcontrib><creatorcontrib>Alasmari, Abdulrahman</creatorcontrib><creatorcontrib>Alzahrani, Othman R</creatorcontrib><creatorcontrib>Aljohani, Saad Ali S</creatorcontrib><creatorcontrib>Alasmael, Noura</creatorcontrib><creatorcontrib>Theyab, Abdulrahman</creatorcontrib><creatorcontrib>Algahtani, Mohammad</creatorcontrib><creatorcontrib>Al Sadoun, Hadeel</creatorcontrib><creatorcontrib>Alsharif, Khalaf F</creatorcontrib><creatorcontrib>Hamad, Abdullah</creatorcontrib><creatorcontrib>Abdali, Wed A</creatorcontrib><creatorcontrib>Hawasawi, Yousef MohammedRabaa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Amer, Osama M</au><au>Oyouni, Atif Abdulwahab A</au><au>Alshehri, Mohammed Ali</au><au>Alasmari, Abdulrahman</au><au>Alzahrani, Othman R</au><au>Aljohani, Saad Ali S</au><au>Alasmael, Noura</au><au>Theyab, Abdulrahman</au><au>Algahtani, Mohammad</au><au>Al Sadoun, Hadeel</au><au>Alsharif, Khalaf F</au><au>Hamad, Abdullah</au><au>Abdali, Wed A</au><au>Hawasawi, Yousef MohammedRabaa</au><au>Ciccacci, Cinzia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-11-15</date><risdate>2021</risdate><volume>16</volume><issue>11</issue><spage>e0257895</spage><pages>e0257895-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin.
The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.
A cohort of 108 female university students aged 18-25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3-5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR.
The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P<0.001) associated with dominant genotypes (TC+CC) and increased risk of IDA while BMP2 rs235756 is significantly (P<0.026) associated with recessive homozygote CC genotypes and increased risk of IDA.
Our finding potentially helps in the early prediction of iron deficiency in females through the genetic testing.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34780475</pmid><doi>10.1371/journal.pone.0257895</doi><tpages>e0257895</tpages><orcidid>https://orcid.org/0000-0001-8762-4999</orcidid><orcidid>https://orcid.org/0000-0002-0188-1634</orcidid><orcidid>https://orcid.org/0000-0002-6152-7709</orcidid><orcidid>https://orcid.org/0000-0003-1901-697X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-11, Vol.16 (11), p.e0257895 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2598034976 |
| source | PubMed Central Free; MEDLINE; Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Alleles Analysis Anemia Anemia, Iron-Deficiency - epidemiology Anemia, Iron-Deficiency - genetics Biology Biology and Life Sciences Biotechnology Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - genetics Case-Control Studies Cohort Studies Female Females Ferritin Genes Genetic aspects Genetic factors Genetic screening Genetic Testing - methods Genomes Genotype Genotypes Genotyping Health risk assessment Health risks Hospitals Humans Iron Iron deficiency Iron deficiency anemia Medical laboratories Medicine Medicine and Health Sciences Membrane Proteins - genetics Nutrient deficiency Polymorphism, Single Nucleotide Risk Factors Saudi Arabia - epidemiology Serine Endopeptidases - genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Students Universities Young Adult |
| title | Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia |
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