Enhanced serodiagnostic potential of a fusion molecule consisting of Rv1793, Rv2628 and a truncated Rv2608 of Mycobacterium tuberculosis

Serodiagnosis of tuberculosis (TB) can be rapid, reliable and cost-effective if the issue of variable antibody responses of TB patients against different Mycobacterium tuberculosis (Mtb) antigens can be overcome by developing fusion proteins containing epitopes from multiple antigens of Mtb. In this...

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Veröffentlicht in:	PloS one 2021-11, Vol.16 (11), p.e0258389-e0258389
Hauptverfasser:	Sulman, Sadaf, Shahid, Saher, Khaliq, Aasia, Ambreen, Atiqa, Khan, Imran H, Cooper, Andrea M, Akhtar, Muhammad Waheed
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Analysis Antibodies Antibodies, Bacterial - blood Antigenic determinants Antigens Antigens, Bacterial - immunology Bacterial Proteins - genetics Bacterial Proteins - immunology BCG BCG vaccines Biology and Life Sciences Biomarkers Care and treatment Cloning Diagnosis Dosage and administration E coli Epitopes Epitopes - immunology Escherichia coli - genetics Escherichia coli - metabolism Female Follow-Up Studies Fusion protein Humans Male Medical diagnosis Medicine and Health Sciences Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - isolation & purification Pakistan - epidemiology Plasmids Proteins Recombinant Fusion Proteins - immunology Research and Analysis Methods Risk factors Sensitivity Sensitivity and Specificity Serologic Tests - methods Serology Sex Sputum Sputum - microbiology Tuberculosis Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - microbiology Viral antibodies Young Adult
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