NKX2-1 re-expression induces cell death through apoptosis and necrosis in dedifferentiated thyroid carcinoma cells

NK2 homeobox 1 (NKX2-1) is a thyroid transcription factor essential for proper thyroid formation and maintaining its physiological function. In thyroid cancer, NKX2-1 expression decreases in parallel with declined differentiation. However, the molecular pathways and mechanisms connecting NKX2-1 to t...

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Veröffentlicht in:	PloS one 2021-11, Vol.16 (11), p.e0259558
Hauptverfasser:	Ito, Yuko, Furuya, Fumihiko, Taki, Katsumi, Suzuki, Hideaki, Shimura, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Analysis Apoptosis Apoptosis - genetics Arginase Biology and Life Sciences Cancer Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology Cell cycle Cell death Cell growth Cell Line, Tumor Cell Survival - genetics Cell viability Complications and side effects Cytomegalovirus Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Homeobox Humans Infections Internal medicine Kinases Laboratories Medical prognosis Medicine Medicine and Health Sciences Mortality Necrosis Nuclear Proteins - genetics Nuclear Proteins - metabolism Papillary thyroid carcinoma Patient outcomes Phenotypes Physiological effects Proteins Reagents RGS Proteins - genetics RGS Proteins - metabolism Signal transduction siRNA Thyroid Thyroid cancer Thyroid Cancer, Papillary - genetics Thyroid Cancer, Papillary - metabolism Thyroid Cancer, Papillary - pathology Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid Nuclear Factor 1 - genetics Thyroid Nuclear Factor 1 - metabolism Thyroid transcription factor 1 Transcription Factors - genetics Transcription Factors - metabolism Tumors
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