Bioinformatics analysis of genes related to iron death in diabetic nephropathy through network and pathway levels based approaches

Diabetic nephropathy is one of the common microvascular complications of diabetes. Iron death is a recently reported way of cell death. To explore the effects of iron death on diabetic nephropathy, iron death score of diabetic nephropathy was analyzed based on the network and pathway levels. Further...

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Veröffentlicht in:	PloS one 2021-11, Vol.16 (11), p.e0259436-e0259436
Hauptverfasser:	Hu, Yaling, Liu, Shuang, Liu, Wenyuan, Zhang, Ziyuan, Liu, Yuxiang, Sun, Dalin, Zhang, Mingyu, Fang, Jingai
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Antioxidants Apoptosis Bioinformatics Biology and Life Sciences Case-Control Studies CD14 antigen Cell death Chromosome 3 Complications Computational Biology - methods Databases, Genetic Datasets Diabetes Diabetes mellitus Diabetic nephropathies Diabetic Nephropathies - genetics Diabetic nephropathy Disease Ferroptosis Gene expression Gene Expression Profiling Gene Regulatory Networks Genes Genetic aspects Genetic transcription Health aspects Hospitals Humans Iron KLF4 protein Lipid peroxidation Lipids Liver cancer Medicine and Health Sciences MicroRNAs - genetics Microvasculature Modules Mortality Nephrology Nephropathy Pathogenesis Physical Sciences Principal Component Analysis Principal components analysis Rac2 protein Research and Analysis Methods Risk factors Runx1 protein Sequence Analysis, RNA Sp1 protein Transcription factors
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