Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study
Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) is useful to diagnose peripheral lung lesions. The data of tumor cell numbers obtained by two differe...
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| Veröffentlicht in: | PloS one 2021-10, Vol.16 (10), p.e0259236-e0259236 |
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| creator | Katsurada, Naoko Tachihara, Motoko Jimbo, Naoe Yamamoto, Masatsugu Yoshioka, Junya Mimura, Chihiro Satoh, Hiroki Furukawa, Koichi Otoshi, Takehiro Kiriu, Tatsunori Yasuda, Yuichiro Tanaka, Tomonori Nagano, Tatsuya Nishimura, Yoshihiro |
| description | Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) is useful to diagnose peripheral lung lesions. The data of tumor cell numbers obtained by two different sizes of GSs is limited. We conducted this study to investigate the utility of a large GS kit to obtain many tumor cells in patients with NSCLC.
Patients with a peripheral lung lesion and suspected of NSCLC were prospectively enrolled. They underwent TBB with a 5.9-mm diameter bronchoscope with a large GS. When the lesion was invisible in EBUS, we changed to a thinner bronchoscope and TBB was performed with a small GS. We compared the tumor cell number prospectively obtained with a large GS (prospective large GS group) and those previously obtained with a small GS (small GS cohort). The primary endpoint was the tumor cell number per sample, and we assessed characteristics of lesions that could be obtained by TBB with large GS.
Biopsy with large GS was performed in 55 of 87 patients (63.2%), and 37 were diagnosed with NSCLC based on histological samples. The number of tumor cells per sample was not different between two groups (658±553 vs. 532±526, estimated difference between two groups with 95% confidence interval (CI); 125 (-125-376), p = 0.32). The sample size of the large GS group was significantly larger than that of the small GS cohort (1.75 mm2 vs. 0.83 mm2, estimated difference with 95% CI; 0.92 (0.60-1.23) mm2, p = 0.00000019). The lesion involving a third or less bronchus generation was predictive factors using large GS.
The sample size obtained with large GS was significantly larger compared to that obtained with small GS, but there was no significant difference in tumor cell number. The 5.9-mm diameter bronchoscope with large GS can be used for lesions involving a third or less bronchus generation. |
| doi_str_mv | 10.1371/journal.pone.0259236 |
| format | Article |
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Patients with a peripheral lung lesion and suspected of NSCLC were prospectively enrolled. They underwent TBB with a 5.9-mm diameter bronchoscope with a large GS. When the lesion was invisible in EBUS, we changed to a thinner bronchoscope and TBB was performed with a small GS. We compared the tumor cell number prospectively obtained with a large GS (prospective large GS group) and those previously obtained with a small GS (small GS cohort). The primary endpoint was the tumor cell number per sample, and we assessed characteristics of lesions that could be obtained by TBB with large GS.
Biopsy with large GS was performed in 55 of 87 patients (63.2%), and 37 were diagnosed with NSCLC based on histological samples. The number of tumor cells per sample was not different between two groups (658±553 vs. 532±526, estimated difference between two groups with 95% confidence interval (CI); 125 (-125-376), p = 0.32). The sample size of the large GS group was significantly larger than that of the small GS cohort (1.75 mm2 vs. 0.83 mm2, estimated difference with 95% CI; 0.92 (0.60-1.23) mm2, p = 0.00000019). The lesion involving a third or less bronchus generation was predictive factors using large GS.
The sample size obtained with large GS was significantly larger compared to that obtained with small GS, but there was no significant difference in tumor cell number. The 5.9-mm diameter bronchoscope with large GS can be used for lesions involving a third or less bronchus generation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0259236</identifier><identifier>PMID: 34714868</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Biology and Life Sciences ; Biopsy ; Bronchoscopy ; Bronchoscopy - methods ; Bronchoscopy - standards ; Bronchus ; Carcinoma, Non-Small-Cell Lung - pathology ; Cell number ; Clinical medicine ; Confidence intervals ; Diagnosis ; Evaluation ; Female ; Genetic aspects ; Humans ; Image-Guided Biopsy - methods ; Image-Guided Biopsy - standards ; Internal medicine ; Lesions ; Lung cancer ; Lung cancer, Non-small cell ; Lung diseases ; Lung Neoplasms - pathology ; Male ; Medical instruments ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Non-small cell lung carcinoma ; Patients ; Research and Analysis Methods ; Sample size ; Sheaths ; Small cell lung carcinoma ; Tumor cells ; Tumors ; Ultrasonography - methods ; Ultrasonography - standards ; Ultrasound imaging ; University graduates</subject><ispartof>PloS one, 2021-10, Vol.16 (10), p.e0259236-e0259236</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Katsurada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Katsurada et al 2021 Katsurada et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-c9b5c3d290afe660d0bf8ef7f621849eab67ea2f0bdf92a5cc03bb4472cf55c63</citedby><cites>FETCH-LOGICAL-c791t-c9b5c3d290afe660d0bf8ef7f621849eab67ea2f0bdf92a5cc03bb4472cf55c63</cites><orcidid>0000-0003-0596-555X ; 0000-0002-9401-466X ; 0000-0002-4598-220X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555788/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555788/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34714868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Males, Jamie</contributor><creatorcontrib>Katsurada, Naoko</creatorcontrib><creatorcontrib>Tachihara, Motoko</creatorcontrib><creatorcontrib>Jimbo, Naoe</creatorcontrib><creatorcontrib>Yamamoto, Masatsugu</creatorcontrib><creatorcontrib>Yoshioka, Junya</creatorcontrib><creatorcontrib>Mimura, Chihiro</creatorcontrib><creatorcontrib>Satoh, Hiroki</creatorcontrib><creatorcontrib>Furukawa, Koichi</creatorcontrib><creatorcontrib>Otoshi, Takehiro</creatorcontrib><creatorcontrib>Kiriu, Tatsunori</creatorcontrib><creatorcontrib>Yasuda, Yuichiro</creatorcontrib><creatorcontrib>Tanaka, Tomonori</creatorcontrib><creatorcontrib>Nagano, Tatsuya</creatorcontrib><creatorcontrib>Nishimura, Yoshihiro</creatorcontrib><title>Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) is useful to diagnose peripheral lung lesions. The data of tumor cell numbers obtained by two different sizes of GSs is limited. We conducted this study to investigate the utility of a large GS kit to obtain many tumor cells in patients with NSCLC.
Patients with a peripheral lung lesion and suspected of NSCLC were prospectively enrolled. They underwent TBB with a 5.9-mm diameter bronchoscope with a large GS. When the lesion was invisible in EBUS, we changed to a thinner bronchoscope and TBB was performed with a small GS. We compared the tumor cell number prospectively obtained with a large GS (prospective large GS group) and those previously obtained with a small GS (small GS cohort). The primary endpoint was the tumor cell number per sample, and we assessed characteristics of lesions that could be obtained by TBB with large GS.
Biopsy with large GS was performed in 55 of 87 patients (63.2%), and 37 were diagnosed with NSCLC based on histological samples. The number of tumor cells per sample was not different between two groups (658±553 vs. 532±526, estimated difference between two groups with 95% confidence interval (CI); 125 (-125-376), p = 0.32). The sample size of the large GS group was significantly larger than that of the small GS cohort (1.75 mm2 vs. 0.83 mm2, estimated difference with 95% CI; 0.92 (0.60-1.23) mm2, p = 0.00000019). The lesion involving a third or less bronchus generation was predictive factors using large GS.
The sample size obtained with large GS was significantly larger compared to that obtained with small GS, but there was no significant difference in tumor cell number. The 5.9-mm diameter bronchoscope with large GS can be used for lesions involving a third or less bronchus generation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Bronchoscopy</subject><subject>Bronchoscopy - methods</subject><subject>Bronchoscopy - standards</subject><subject>Bronchus</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell number</subject><subject>Clinical medicine</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Evaluation</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Image-Guided Biopsy - methods</subject><subject>Image-Guided Biopsy - standards</subject><subject>Internal medicine</subject><subject>Lesions</subject><subject>Lung cancer</subject><subject>Lung cancer, Non-small cell</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical instruments</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Non-small cell lung carcinoma</subject><subject>Patients</subject><subject>Research and Analysis Methods</subject><subject>Sample size</subject><subject>Sheaths</subject><subject>Small cell lung carcinoma</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>Ultrasonography - methods</subject><subject>Ultrasonography - standards</subject><subject>Ultrasound imaging</subject><subject>University 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of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study</title><author>Katsurada, Naoko ; Tachihara, Motoko ; Jimbo, Naoe ; Yamamoto, Masatsugu ; Yoshioka, Junya ; Mimura, Chihiro ; Satoh, Hiroki ; Furukawa, Koichi ; Otoshi, Takehiro ; Kiriu, Tatsunori ; Yasuda, Yuichiro ; Tanaka, Tomonori ; Nagano, Tatsuya ; Nishimura, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c791t-c9b5c3d290afe660d0bf8ef7f621849eab67ea2f0bdf92a5cc03bb4472cf55c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Bronchoscopy</topic><topic>Bronchoscopy - methods</topic><topic>Bronchoscopy - standards</topic><topic>Bronchus</topic><topic>Carcinoma, Non-Small-Cell Lung - 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Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katsurada, Naoko</au><au>Tachihara, Motoko</au><au>Jimbo, Naoe</au><au>Yamamoto, Masatsugu</au><au>Yoshioka, Junya</au><au>Mimura, Chihiro</au><au>Satoh, Hiroki</au><au>Furukawa, Koichi</au><au>Otoshi, Takehiro</au><au>Kiriu, Tatsunori</au><au>Yasuda, Yuichiro</au><au>Tanaka, Tomonori</au><au>Nagano, Tatsuya</au><au>Nishimura, Yoshihiro</au><au>Males, Jamie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-10-29</date><risdate>2021</risdate><volume>16</volume><issue>10</issue><spage>e0259236</spage><epage>e0259236</epage><pages>e0259236-e0259236</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) is useful to diagnose peripheral lung lesions. The data of tumor cell numbers obtained by two different sizes of GSs is limited. We conducted this study to investigate the utility of a large GS kit to obtain many tumor cells in patients with NSCLC.
Patients with a peripheral lung lesion and suspected of NSCLC were prospectively enrolled. They underwent TBB with a 5.9-mm diameter bronchoscope with a large GS. When the lesion was invisible in EBUS, we changed to a thinner bronchoscope and TBB was performed with a small GS. We compared the tumor cell number prospectively obtained with a large GS (prospective large GS group) and those previously obtained with a small GS (small GS cohort). The primary endpoint was the tumor cell number per sample, and we assessed characteristics of lesions that could be obtained by TBB with large GS.
Biopsy with large GS was performed in 55 of 87 patients (63.2%), and 37 were diagnosed with NSCLC based on histological samples. The number of tumor cells per sample was not different between two groups (658±553 vs. 532±526, estimated difference between two groups with 95% confidence interval (CI); 125 (-125-376), p = 0.32). The sample size of the large GS group was significantly larger than that of the small GS cohort (1.75 mm2 vs. 0.83 mm2, estimated difference with 95% CI; 0.92 (0.60-1.23) mm2, p = 0.00000019). The lesion involving a third or less bronchus generation was predictive factors using large GS.
The sample size obtained with large GS was significantly larger compared to that obtained with small GS, but there was no significant difference in tumor cell number. The 5.9-mm diameter bronchoscope with large GS can be used for lesions involving a third or less bronchus generation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34714868</pmid><doi>10.1371/journal.pone.0259236</doi><tpages>e0259236</tpages><orcidid>https://orcid.org/0000-0003-0596-555X</orcidid><orcidid>https://orcid.org/0000-0002-9401-466X</orcidid><orcidid>https://orcid.org/0000-0002-4598-220X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-10, Vol.16 (10), p.e0259236-e0259236 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2588314694 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Biology and Life Sciences Biopsy Bronchoscopy Bronchoscopy - methods Bronchoscopy - standards Bronchus Carcinoma, Non-Small-Cell Lung - pathology Cell number Clinical medicine Confidence intervals Diagnosis Evaluation Female Genetic aspects Humans Image-Guided Biopsy - methods Image-Guided Biopsy - standards Internal medicine Lesions Lung cancer Lung cancer, Non-small cell Lung diseases Lung Neoplasms - pathology Male Medical instruments Medicine Medicine and Health Sciences Middle Aged Non-small cell lung carcinoma Patients Research and Analysis Methods Sample size Sheaths Small cell lung carcinoma Tumor cells Tumors Ultrasonography - methods Ultrasonography - standards Ultrasound imaging University graduates |
| title | Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study |
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