Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience
This study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome. A detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution...
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| Veröffentlicht in: | PloS one 2021-10, Vol.16 (10), p.e0259095-e0259095 |
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| creator | Stanić, Dragana Grujičić, Danica Pekmezović, Tatjana Bokun, Jelena Popović-Vuković, Marija Janić, Dragana Paripović, Lejla Ilić, Vesna Pudrlja Slović, Marija Ilić, Rosanda Raičević, Savo Sarić, Milan Mišković, Ivana Nidžović, Borko Nikitović, Marina |
| description | This study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome.
A detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution between 2007 and 2016, based on their clinical, histological, treatment, and follow-up data.
Mean survival time of all children was 94.5months. 2-, 5- and 10-year overall survival probabilities were 68.8%, 59.4%, and 52.8%, respectively. Patients with supratentorial tumors had longer survival than patients with infratentorial tumors and patients with tumors in both compartments (p = 0.011). Children with the unknown histopathology (brainstem glioma) and high-grade glioma had a shorter life than embryonal tumors, ependymoma, and low-grade glioma (p |
| doi_str_mv | 10.1371/journal.pone.0259095 |
| format | Article |
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A detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution between 2007 and 2016, based on their clinical, histological, treatment, and follow-up data.
Mean survival time of all children was 94.5months. 2-, 5- and 10-year overall survival probabilities were 68.8%, 59.4%, and 52.8%, respectively. Patients with supratentorial tumors had longer survival than patients with infratentorial tumors and patients with tumors in both compartments (p = 0.011). Children with the unknown histopathology (brainstem glioma) and high-grade glioma had a shorter life than embryonal tumors, ependymoma, and low-grade glioma (p<0.001). Survival of the children who underwent gross total resection was longer than the children in whom lesser degrees of resection were achieved (p = 0.015). The extent of the disease is a very important parameter found to be associated with survival. Patients with no evidence of disease after surgery had a mean survival of 123 months, compared with 82 months in patients with local residual disease and 55 months in patients with disseminated disease (p<0.001). By the univariate analysis, factors predicting poor outcome in our series were the presentation of disease with hormonal abnormalities, tumor location, and the extent of the disease, while the factors predicting a better outcome were age at the time of diagnosis, presentation of the disease with neurological deficit, and type of resection. By the multivariate analysis, the extent of the disease remained as the only strong adverse risk factor for survival (HR 2.06; 95% CI = 1.38-3.07; p<0.001).
With an organized and dedicated multidisciplinary team, the adequate outcomes can be achieved in a middle-income country setting. The presence of local residual disease after surgery and disseminated disease has a strong negative effect on survival.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0259095</identifier><identifier>PMID: 34699548</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adolescent ; Antineoplastic Agents - therapeutic use ; Brain ; Brain cancer ; Brain Neoplasms - mortality ; Brain Neoplasms - pathology ; Brain Neoplasms - therapy ; Brain stem ; Brain tumors ; Cancer therapies ; Care and treatment ; Chemotherapy ; Child ; Child, Preschool ; Children ; Disease ; Diseases ; Female ; Glioma ; Glioma - mortality ; Glioma - pathology ; Glioma - therapy ; Health physics ; Health services ; Histopathology ; Humans ; Infant ; Infant, Newborn ; Localization ; Male ; Medical imaging ; Medical records ; Medicine ; Medicine and Health Sciences ; Multidisciplinary teams ; Multivariate analysis ; Neurosurgery ; Neurosurgical Procedures ; Oncology ; Patient outcomes ; Patients ; Pediatrics ; Physics ; Prognosis ; Radiation therapy ; Radiotherapy ; Risk analysis ; Risk factors ; Serbia ; Surgery ; Survival ; Survival Rate ; Treatment Outcome ; Tumors</subject><ispartof>PloS one, 2021-10, Vol.16 (10), p.e0259095-e0259095</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Stanić et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Stanić et al 2021 Stanić et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-d80a005a0cf0fd9f96e2add9fc088ccf05a74fade7d8ea6627024829f8a948483</citedby><cites>FETCH-LOGICAL-c653t-d80a005a0cf0fd9f96e2add9fc088ccf05a74fade7d8ea6627024829f8a948483</cites><orcidid>0000-0001-7978-1409 ; 0000-0001-7272-9587 ; 0000-0002-8335-5661</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547703/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547703/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34699548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stanić, Dragana</creatorcontrib><creatorcontrib>Grujičić, Danica</creatorcontrib><creatorcontrib>Pekmezović, Tatjana</creatorcontrib><creatorcontrib>Bokun, Jelena</creatorcontrib><creatorcontrib>Popović-Vuković, Marija</creatorcontrib><creatorcontrib>Janić, Dragana</creatorcontrib><creatorcontrib>Paripović, Lejla</creatorcontrib><creatorcontrib>Ilić, Vesna</creatorcontrib><creatorcontrib>Pudrlja Slović, Marija</creatorcontrib><creatorcontrib>Ilić, Rosanda</creatorcontrib><creatorcontrib>Raičević, Savo</creatorcontrib><creatorcontrib>Sarić, Milan</creatorcontrib><creatorcontrib>Mišković, Ivana</creatorcontrib><creatorcontrib>Nidžović, Borko</creatorcontrib><creatorcontrib>Nikitović, Marina</creatorcontrib><title>Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome.
A detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution between 2007 and 2016, based on their clinical, histological, treatment, and follow-up data.
Mean survival time of all children was 94.5months. 2-, 5- and 10-year overall survival probabilities were 68.8%, 59.4%, and 52.8%, respectively. Patients with supratentorial tumors had longer survival than patients with infratentorial tumors and patients with tumors in both compartments (p = 0.011). Children with the unknown histopathology (brainstem glioma) and high-grade glioma had a shorter life than embryonal tumors, ependymoma, and low-grade glioma (p<0.001). Survival of the children who underwent gross total resection was longer than the children in whom lesser degrees of resection were achieved (p = 0.015). The extent of the disease is a very important parameter found to be associated with survival. Patients with no evidence of disease after surgery had a mean survival of 123 months, compared with 82 months in patients with local residual disease and 55 months in patients with disseminated disease (p<0.001). By the univariate analysis, factors predicting poor outcome in our series were the presentation of disease with hormonal abnormalities, tumor location, and the extent of the disease, while the factors predicting a better outcome were age at the time of diagnosis, presentation of the disease with neurological deficit, and type of resection. By the multivariate analysis, the extent of the disease remained as the only strong adverse risk factor for survival (HR 2.06; 95% CI = 1.38-3.07; p<0.001).
With an organized and dedicated multidisciplinary team, the adequate outcomes can be achieved in a middle-income country setting. The presence of local residual disease after surgery and disseminated disease has a strong negative effect on survival.</description><subject>Abnormalities</subject><subject>Adolescent</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - therapy</subject><subject>Brain stem</subject><subject>Brain tumors</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Disease</subject><subject>Diseases</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - mortality</subject><subject>Glioma - pathology</subject><subject>Glioma - therapy</subject><subject>Health physics</subject><subject>Health services</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Localization</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Multidisciplinary teams</subject><subject>Multivariate analysis</subject><subject>Neurosurgery</subject><subject>Neurosurgical Procedures</subject><subject>Oncology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Physics</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Serbia</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Treatment 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profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience</title><author>Stanić, Dragana ; Grujičić, Danica ; Pekmezović, Tatjana ; Bokun, Jelena ; Popović-Vuković, Marija ; Janić, Dragana ; Paripović, Lejla ; Ilić, Vesna ; Pudrlja Slović, Marija ; Ilić, Rosanda ; Raičević, Savo ; Sarić, Milan ; Mišković, Ivana ; Nidžović, Borko ; Nikitović, Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-d80a005a0cf0fd9f96e2add9fc088ccf05a74fade7d8ea6627024829f8a948483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abnormalities</topic><topic>Adolescent</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Brain</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - therapy</topic><topic>Brain 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stanić, Dragana</au><au>Grujičić, Danica</au><au>Pekmezović, Tatjana</au><au>Bokun, Jelena</au><au>Popović-Vuković, Marija</au><au>Janić, Dragana</au><au>Paripović, Lejla</au><au>Ilić, Vesna</au><au>Pudrlja Slović, Marija</au><au>Ilić, Rosanda</au><au>Raičević, Savo</au><au>Sarić, Milan</au><au>Mišković, Ivana</au><au>Nidžović, Borko</au><au>Nikitović, Marina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-10-26</date><risdate>2021</risdate><volume>16</volume><issue>10</issue><spage>e0259095</spage><epage>e0259095</epage><pages>e0259095-e0259095</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome.
A detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution between 2007 and 2016, based on their clinical, histological, treatment, and follow-up data.
Mean survival time of all children was 94.5months. 2-, 5- and 10-year overall survival probabilities were 68.8%, 59.4%, and 52.8%, respectively. Patients with supratentorial tumors had longer survival than patients with infratentorial tumors and patients with tumors in both compartments (p = 0.011). Children with the unknown histopathology (brainstem glioma) and high-grade glioma had a shorter life than embryonal tumors, ependymoma, and low-grade glioma (p<0.001). Survival of the children who underwent gross total resection was longer than the children in whom lesser degrees of resection were achieved (p = 0.015). The extent of the disease is a very important parameter found to be associated with survival. Patients with no evidence of disease after surgery had a mean survival of 123 months, compared with 82 months in patients with local residual disease and 55 months in patients with disseminated disease (p<0.001). By the univariate analysis, factors predicting poor outcome in our series were the presentation of disease with hormonal abnormalities, tumor location, and the extent of the disease, while the factors predicting a better outcome were age at the time of diagnosis, presentation of the disease with neurological deficit, and type of resection. By the multivariate analysis, the extent of the disease remained as the only strong adverse risk factor for survival (HR 2.06; 95% CI = 1.38-3.07; p<0.001).
With an organized and dedicated multidisciplinary team, the adequate outcomes can be achieved in a middle-income country setting. The presence of local residual disease after surgery and disseminated disease has a strong negative effect on survival.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34699548</pmid><doi>10.1371/journal.pone.0259095</doi><tpages>e0259095</tpages><orcidid>https://orcid.org/0000-0001-7978-1409</orcidid><orcidid>https://orcid.org/0000-0001-7272-9587</orcidid><orcidid>https://orcid.org/0000-0002-8335-5661</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-10, Vol.16 (10), p.e0259095-e0259095 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2586414457 |
| source | MEDLINE; Public Library of Science; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Abnormalities Adolescent Antineoplastic Agents - therapeutic use Brain Brain cancer Brain Neoplasms - mortality Brain Neoplasms - pathology Brain Neoplasms - therapy Brain stem Brain tumors Cancer therapies Care and treatment Chemotherapy Child Child, Preschool Children Disease Diseases Female Glioma Glioma - mortality Glioma - pathology Glioma - therapy Health physics Health services Histopathology Humans Infant Infant, Newborn Localization Male Medical imaging Medical records Medicine Medicine and Health Sciences Multidisciplinary teams Multivariate analysis Neurosurgery Neurosurgical Procedures Oncology Patient outcomes Patients Pediatrics Physics Prognosis Radiation therapy Radiotherapy Risk analysis Risk factors Serbia Surgery Survival Survival Rate Treatment Outcome Tumors |
| title | Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T16%3A02%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20profile,%20treatment%20and%20outcome%20of%20pediatric%20brain%20tumors%20in%20Serbia%20in%20a%2010-year%20period:%20A%20national%20referral%20institution%20experience&rft.jtitle=PloS%20one&rft.au=Stani%C4%87,%20Dragana&rft.date=2021-10-26&rft.volume=16&rft.issue=10&rft.spage=e0259095&rft.epage=e0259095&rft.pages=e0259095-e0259095&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0259095&rft_dat=%3Cgale_plos_%3EA680277649%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2586414457&rft_id=info:pmid/34699548&rft_galeid=A680277649&rft_doaj_id=oai_doaj_org_article_117c0a34c6764030ad04c41d4985a0a6&rfr_iscdi=true |