Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study
Myocardial perfusion imaging (MPI) is a well-established diagnostic tool to evaluate coronary artery disease (CAD) and also an effective prognostic tool for patients with CAD. However, few studies investigated the prognostic value of attenuation correction (AC) in MPI, and the results were controver...
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| description | Myocardial perfusion imaging (MPI) is a well-established diagnostic tool to evaluate coronary artery disease (CAD) and also an effective prognostic tool for patients with CAD. However, few studies investigated the prognostic value of attenuation correction (AC) in MPI, and the results were controversial.
To investigate the prognostic value of computed tomography (CT)-based AC thallium-201 (Tl-201) MPI.
A total of 108 consecutive patients who underwent Tl-201 MPI and received coronary angiography within 90 days were included. Medical records were reviewed and missing information was completed after telephone contact. The prognostic value was evaluated by Kaplan-Meier analysis, univariable and multivariable Cox proportional hazards model.
After a mean follow-up of 7.72 ± 3.72 years, 27 patients had died, 41 had been readmitted for cardiovascular (CV)-related events and 44 had reached the composite of death plus CV-related re-admission. Kaplan-Meier curves for all-cause mortality for SSS with a cutoff value of 13 for AC and 16 for non-AC (NAC) images showed a significant difference between the two curves for both AC and NAC images (p = 0.011 for AC and p = 0.021 for NAC). In the multivariable model, SSS and SRS showed similar independent predictive values in predicting all-cause mortality and composite of all-cause mortality plus CV-related re-admission, in both AC and NAC images. Subgroup analysis implicated that AC MPI possibly provided better risk stratification in obese patients.
CT-based AC and NAC MPI showed similar value and were the only significant predictors for the composite of mortality and CV events. |
| doi_str_mv | 10.1371/journal.pone.0258983 |
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To investigate the prognostic value of computed tomography (CT)-based AC thallium-201 (Tl-201) MPI.
A total of 108 consecutive patients who underwent Tl-201 MPI and received coronary angiography within 90 days were included. Medical records were reviewed and missing information was completed after telephone contact. The prognostic value was evaluated by Kaplan-Meier analysis, univariable and multivariable Cox proportional hazards model.
After a mean follow-up of 7.72 ± 3.72 years, 27 patients had died, 41 had been readmitted for cardiovascular (CV)-related events and 44 had reached the composite of death plus CV-related re-admission. Kaplan-Meier curves for all-cause mortality for SSS with a cutoff value of 13 for AC and 16 for non-AC (NAC) images showed a significant difference between the two curves for both AC and NAC images (p = 0.011 for AC and p = 0.021 for NAC). In the multivariable model, SSS and SRS showed similar independent predictive values in predicting all-cause mortality and composite of all-cause mortality plus CV-related re-admission, in both AC and NAC images. Subgroup analysis implicated that AC MPI possibly provided better risk stratification in obese patients.
CT-based AC and NAC MPI showed similar value and were the only significant predictors for the composite of mortality and CV events.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0258983</identifier><identifier>PMID: 34699538</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Angiography ; Attenuation ; Biology and Life Sciences ; Cohort analysis ; Computed tomography ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - mortality ; Coronary heart disease ; Drug dosages ; Evaluation ; Female ; Health risks ; Heart diseases ; Heart failure ; Humans ; Male ; Medical imaging ; Medical prognosis ; Medical records ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Myocardial Perfusion Imaging ; Obesity ; Patients ; Perfusion ; Preventive medicine ; Prognosis ; Research and Analysis Methods ; Statistical models ; Subgroups ; Survival Rate ; Thallium ; Thallium isotopes ; Thallium Radioisotopes ; Thallium-201 ; Tomography ; Tomography, X-Ray Computed</subject><ispartof>PloS one, 2021-10, Vol.16 (10), p.e0258983-e0258983</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Huang et al 2021 Huang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-33c824ec4b44127bd9db5cca337eefc98c17f4fb92707eca6d5f109cd41a39d83</citedby><cites>FETCH-LOGICAL-c692t-33c824ec4b44127bd9db5cca337eefc98c17f4fb92707eca6d5f109cd41a39d83</cites><orcidid>0000-0003-1520-1166</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547642/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547642/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34699538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nakamura, Michinari</contributor><creatorcontrib>Huang, Jei-Yie</creatorcontrib><creatorcontrib>Yen, Ruoh-Fang</creatorcontrib><creatorcontrib>Huang, Chun-Kai</creatorcontrib><creatorcontrib>Liu, Chia-Ju</creatorcontrib><creatorcontrib>Cheng, Mei-Fang</creatorcontrib><creatorcontrib>Chien, Kuo-Liong</creatorcontrib><creatorcontrib>Wu, Yen-Wen</creatorcontrib><title>Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Myocardial perfusion imaging (MPI) is a well-established diagnostic tool to evaluate coronary artery disease (CAD) and also an effective prognostic tool for patients with CAD. However, few studies investigated the prognostic value of attenuation correction (AC) in MPI, and the results were controversial.
To investigate the prognostic value of computed tomography (CT)-based AC thallium-201 (Tl-201) MPI.
A total of 108 consecutive patients who underwent Tl-201 MPI and received coronary angiography within 90 days were included. Medical records were reviewed and missing information was completed after telephone contact. The prognostic value was evaluated by Kaplan-Meier analysis, univariable and multivariable Cox proportional hazards model.
After a mean follow-up of 7.72 ± 3.72 years, 27 patients had died, 41 had been readmitted for cardiovascular (CV)-related events and 44 had reached the composite of death plus CV-related re-admission. Kaplan-Meier curves for all-cause mortality for SSS with a cutoff value of 13 for AC and 16 for non-AC (NAC) images showed a significant difference between the two curves for both AC and NAC images (p = 0.011 for AC and p = 0.021 for NAC). In the multivariable model, SSS and SRS showed similar independent predictive values in predicting all-cause mortality and composite of all-cause mortality plus CV-related re-admission, in both AC and NAC images. Subgroup analysis implicated that AC MPI possibly provided better risk stratification in obese patients.
CT-based AC and NAC MPI showed similar value and were the only significant predictors for the composite of mortality and CV events.</description><subject>Aged</subject><subject>Angiography</subject><subject>Attenuation</subject><subject>Biology and Life Sciences</subject><subject>Cohort analysis</subject><subject>Computed tomography</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary heart disease</subject><subject>Drug dosages</subject><subject>Evaluation</subject><subject>Female</subject><subject>Health risks</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Perfusion Imaging</subject><subject>Obesity</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Preventive medicine</subject><subject>Prognosis</subject><subject>Research and Analysis Methods</subject><subject>Statistical models</subject><subject>Subgroups</subject><subject>Survival Rate</subject><subject>Thallium</subject><subject>Thallium isotopes</subject><subject>Thallium Radioisotopes</subject><subject>Thallium-201</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7rr6DUQLguhDx6TpNI0PwrB4GRhY8PYaTpP0sqRNTdLF-Qx-adOZ7jKVfZAGmpz8zv-cnORE0XOMVphQ_O7ajLYHvRpMr1YoXResIA-ic8xImuQpIg9P5mfRE-euEVqTIs8fR2ckyxkLi_Poz870deKV7eLBmro3zrcivgE9qthUsTDdMHolY286U1sYmn1SggsG8F71I_jW9IGyVonDNAzfgNbt2CUpwnG3NwKsbEHHg7LV6Cao7aBu-_p9vAmujbE-dn6U-6fRowq0U8_m_0X049PH75dfkt3V5-3lZpeInKU-IUQUaaZEVmYZTmkpmSzXQgAhVKlKsEJgWmVVyVKKqBKQy3WFERMyw0CYLMhF9PKoO2jj-FxHx0MJ8wxnKMeB2B4JaeCaDzYkbPfcQMsPBmNrDjYUSisuS8BMFKQAiUPQokBpSQlIiRVbI4GC1oc52lh2SgrVewt6Ibrc6duG1-aGF-uM5lkaBN7MAtb8GpXzvGudUFpDr8x4yJuGq2VsQl_9g95_upmqIRyg7SsT4opJlG_ykD-lOaGBWt1DhU-qrhXh0VVtsC8c3i4cAuPVb1_D6Bzffvv6_-zVzyX7-oRtFGjfOKPH6b25JZgdQWGNc1ZVd0XGiE89c1sNPvUMn3smuL04vaA7p9smIX8BmUAVDg</recordid><startdate>20211026</startdate><enddate>20211026</enddate><creator>Huang, 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prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study</title><author>Huang, Jei-Yie ; Yen, Ruoh-Fang ; Huang, Chun-Kai ; Liu, Chia-Ju ; Cheng, Mei-Fang ; Chien, Kuo-Liong ; Wu, Yen-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-33c824ec4b44127bd9db5cca337eefc98c17f4fb92707eca6d5f109cd41a39d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Angiography</topic><topic>Attenuation</topic><topic>Biology and Life Sciences</topic><topic>Cohort analysis</topic><topic>Computed tomography</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary heart disease</topic><topic>Drug 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Jei-Yie</au><au>Yen, Ruoh-Fang</au><au>Huang, Chun-Kai</au><au>Liu, Chia-Ju</au><au>Cheng, Mei-Fang</au><au>Chien, Kuo-Liong</au><au>Wu, Yen-Wen</au><au>Nakamura, Michinari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-10-26</date><risdate>2021</risdate><volume>16</volume><issue>10</issue><spage>e0258983</spage><epage>e0258983</epage><pages>e0258983-e0258983</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Myocardial perfusion imaging (MPI) is a well-established diagnostic tool to evaluate coronary artery disease (CAD) and also an effective prognostic tool for patients with CAD. However, few studies investigated the prognostic value of attenuation correction (AC) in MPI, and the results were controversial.
To investigate the prognostic value of computed tomography (CT)-based AC thallium-201 (Tl-201) MPI.
A total of 108 consecutive patients who underwent Tl-201 MPI and received coronary angiography within 90 days were included. Medical records were reviewed and missing information was completed after telephone contact. The prognostic value was evaluated by Kaplan-Meier analysis, univariable and multivariable Cox proportional hazards model.
After a mean follow-up of 7.72 ± 3.72 years, 27 patients had died, 41 had been readmitted for cardiovascular (CV)-related events and 44 had reached the composite of death plus CV-related re-admission. Kaplan-Meier curves for all-cause mortality for SSS with a cutoff value of 13 for AC and 16 for non-AC (NAC) images showed a significant difference between the two curves for both AC and NAC images (p = 0.011 for AC and p = 0.021 for NAC). In the multivariable model, SSS and SRS showed similar independent predictive values in predicting all-cause mortality and composite of all-cause mortality plus CV-related re-admission, in both AC and NAC images. Subgroup analysis implicated that AC MPI possibly provided better risk stratification in obese patients.
CT-based AC and NAC MPI showed similar value and were the only significant predictors for the composite of mortality and CV events.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34699538</pmid><doi>10.1371/journal.pone.0258983</doi><tpages>e0258983</tpages><orcidid>https://orcid.org/0000-0003-1520-1166</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-10, Vol.16 (10), p.e0258983-e0258983 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2586414061 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Angiography Attenuation Biology and Life Sciences Cohort analysis Computed tomography Coronary artery Coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - mortality Coronary heart disease Drug dosages Evaluation Female Health risks Heart diseases Heart failure Humans Male Medical imaging Medical prognosis Medical records Medicine and Health Sciences Middle Aged Mortality Myocardial Perfusion Imaging Obesity Patients Perfusion Preventive medicine Prognosis Research and Analysis Methods Statistical models Subgroups Survival Rate Thallium Thallium isotopes Thallium Radioisotopes Thallium-201 Tomography Tomography, X-Ray Computed |
| title | Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T17%3A16%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20prognostic%20value%20of%20computed%20tomography-based%20attenuation%20correction%20on%20thallium-201%20myocardial%20perfusion%20imaging:%20A%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Huang,%20Jei-Yie&rft.date=2021-10-26&rft.volume=16&rft.issue=10&rft.spage=e0258983&rft.epage=e0258983&rft.pages=e0258983-e0258983&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0258983&rft_dat=%3Cgale_plos_%3EA680277637%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2586414061&rft_id=info:pmid/34699538&rft_galeid=A680277637&rft_doaj_id=oai_doaj_org_article_dba19c838ad14fb8802b73add1e950c0&rfr_iscdi=true |