Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach

PIM1, is a serine/threonine proto-oncogene kinase, involved in many biological functions, including cell survival, proliferation, and differentiation, thus play a key role in oncogenesis. It plays a crucial role in the onset and progression of various hematopoietic and non-hematopoietic malignancies...

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Veröffentlicht in:	PloS one 2021-10, Vol.16 (10), p.e0258929
Hauptverfasser:	Shafie, Alaa, Khan, Shama, Batra, Sagar, Anjum, Farah, Mohammad, Taj, Alam, Shoaib, Yadav, Dharmendra Kumar, Islam, Asimul, Hassan, Md Imtaiyaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Algorithms Amino Acid Substitution Amino acids Analysis Apoptosis Binding sites Cell cycle Cell differentiation Cell survival Computer applications Domains Gene expression Genetic aspects Genomics Humans Interdisciplinary aspects Kinases Leukemia Medical laboratories Molecular dynamics Mutation Myeloid leukemia Prostate cancer Proteins Proto-Oncogene Proteins c-pim-1 - genetics Proto-Oncogene Proteins c-pim-1 - metabolism Signal transduction Threonine Tumorigenesis
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