IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene

Meiosis initiation and progression are regulated by both germ cells and gonadal somatic cells. However, little is known about what genes or proteins connecting somatic and germ cells are required for this regulation. Our results show that deficiency for adhesion molecule IGSF11, which is expressed i...

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Veröffentlicht in:	PLoS genetics 2021-09, Vol.17 (9), p.e1009778-e1009778
Hauptverfasser:	Chen, Bo, Zhu, Gengzhen, Yan, An, He, Jing, Liu, Yang, Li, Lin, Yang, Xuerui, Dong, Chen, Kee, Kehkooi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Cell adhesion & migration Cell Adhesion Molecules - genetics Cell Adhesion Molecules - physiology Chromatin Chromosomes Engineering and Technology Female Genes, Reporter Genetic aspects Germ cells Heterochromatin Heterochromatin - metabolism Humans Immunoglobulins Immunoglobulins - genetics Immunoglobulins - physiology Infertility Localization Male Medicine and Health Sciences Meiosis Meiotic Prophase I Mice Ovaries Pachytene Physiological aspects Proteins Sertoli cells Sertoli Cells - metabolism Somatic cells Spermatocytes Spermatocytes - metabolism Transgenic animals Transplantation
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