HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment the core is released into the cytoplasm, it interacts with a range of cellular factors that, ultimately, direct the pre-integration complex to the integration site. For integration to occur, the CA lattice m...

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Veröffentlicht in:	PLoS pathogens 2021-09, Vol.17 (9), p.e1009484-e1009484
Hauptverfasser:	Guedán, Anabel, Donaldson, Callum D, Caroe, Eve R, Cosnefroy, Ophélie, Taylor, Ian A, Bishop, Kate N
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Capsid Proteins - metabolism Capsids Chromatin Complementary DNA Cores Cytoplasm Development and progression Genetic aspects Genomes HEK293 Cells HeLa Cells HIV HIV infection HIV-1 - physiology Host-virus relationships Human immunodeficiency virus Humans Immunofluorescence Infections Infectivity Integration Interfaces Medicine and Health Sciences Mutants Mutation Nuclear membranes Nuclear Pore Physiological aspects Proteins Reduction Research and analysis methods Reverse transcription Stability Structure Uncoating Viral envelopes Virus Integration - physiology Virus Replication - physiology Viruses
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