Teaching a new mouse old tricks: Humanized mice as an infection model for Variola virus

Smallpox, caused by the solely human pathogen Variola virus (VARV), was declared eradicated in 1980. While known VARV stocks are secure, smallpox remains a bioterrorist threat agent. Recent U.S. Food and Drug Administration approval of the first smallpox anti-viral (tecovirimat) therapeutic was a su...

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Veröffentlicht in:	PLoS pathogens 2021-09, Vol.17 (9), p.e1009633-e1009633
Hauptverfasser:	Hutson, Christina L, Kondas, Ashley V, Ritter, Jana M, Reed, Zachary, Ostergaard, Sharon Dietz, Morgan, Clint N, Gallardo-Romero, Nadia, Tansey, Cassandra, Mauldin, Matthew R, Salzer, Johanna S, Hughes, Christine M, Goldsmith, Cynthia S, Carroll, Darin, Olson, Victoria A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal experimentation Animal models Animals Antiviral agents Biology and life sciences Bioterrorism Diagnosis Disease Disease Models, Animal Disease susceptibility Disease transmission FDA approval Health aspects Humans Immune system Infections Laboratories Medicine and Health Sciences Methods Mice Model testing Mortality Pain Pathogens Physiological aspects Prevention Regulatory approval Research and Analysis Methods Risk factors Smallpox Treatment resistance Variola virus Viral infections Viruses
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