Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting a...
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| Veröffentlicht in: | PLoS biology 2021-09, Vol.19 (9), p.e3001353 |
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| description | Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response. |
| doi_str_mv | 10.1371/journal.pbio.3001353 |
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| source | MEDLINE; Public Library of Science; PubMed Central; Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Antiviral drugs Bias Biology and life sciences CpG islands CpG Islands - genetics Defense mechanisms DNA methylation Evolution Gene expression Genomes Immune response Immune system Interferon Medicine and Health Sciences Nucleotides Pathogens Physiological aspects Primer Proteins RNA-Binding Proteins - genetics Viral infections Virus Replication Viruses Zinc finger proteins |
| title | Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity |
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