Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill patients show an impaired type I IFN response accompanied by elevated inflammatory cytokine and chemokine levels, respon...

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Veröffentlicht in:	PLoS pathogens 2021-09, Vol.17 (9), p.e1009878-e1009878
Hauptverfasser:	Severa, Martina, Diotti, Roberta A, Etna, Marilena P, Rizzo, Fabiana, Fiore, Stefano, Ricci, Daniela, Iannetta, Marco, Sinigaglia, Alessandro, Lodi, Alessandra, Mancini, Nicasio, Criscuolo, Elena, Clementi, Massimo, Andreoni, Massimo, Balducci, Stefano, Barzon, Luisa, Stefanelli, Paola, Clementi, Nicola, Coccia, Eliana M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents Asymptomatic Biology and life sciences Carrier state (Communicable diseases) Cell culture Cell interaction Cell surface Chemokines Coronaviruses COVID-19 Cytokine storm Cytokines Dendritic cells Development and progression Disease Epithelial cells Epithelium Experiments Gene expression Health aspects Immune response Immune system Infections Inflammation Interferon Ligands Medicine and health sciences Movement disorders Neuropilin PD-L1 protein Peripheral blood mononuclear cells Phenotypes Pneumonia Replication Respiratory diseases Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 TLR7 protein Toll-like receptors Very Low Frequencies Viral diseases Viral infections Viruses
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