Interplay of Trypanosome Lytic Factor and innate immune cells in the resolution of cutaneous Leishmania infection

Trypanosome Lytic Factor (TLF) is a primate-specific high-density lipoprotein (HDL) complex that, through the cation channel-forming protein apolipoprotein L-1 (APOL1), provides innate immunity to select kinetoplastid parasites. The immunoprotective effects of TLF have been extensively investigated...

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Veröffentlicht in:	PLoS pathogens 2021-09, Vol.17 (9), p.e1008768-e1008768
Hauptverfasser:	Pant, Jyoti, Samanovic, Marie, Nelson, Maria T, Keceli, Mert K, Verdi, Joseph, Beverley, Stephen M, Raper, Jayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Amastigotes Apolipoproteins Biology and Life Sciences Care and treatment Chromatography Development and progression Engineering and Technology Genes Glycoconjugates Health aspects High density lipoprotein High density lipoproteins Host-parasite interactions Host-parasite relationships Immune response Immune system Immunity Infections Innate immunity Ion channels Laboratories Leishmania Leishmaniasis, Cutaneous Leukocytes Leukocytes (neutrophilic) Lysis Mammals Medicine and Health Sciences Monkeys & apes Neutrophils Parasites Phagocytes Phagocytosis Physiological aspects Plasma Promastigotes Proteins Protozoa Research and Analysis Methods Rodents Transgenic animals Trypanosome
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