Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs
Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet b...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2021-09, Vol.15 (9), p.e0009736-e0009736 |
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| creator | Santos, Ana Amélia Nunes Ribeiro, Priscyla Dos Santos da França, Geórgia Virgínia Souza, Fábio Neves Ramos, Eduardo Antônio Gonçalves Figueira, Cláudio Pereira Reis, Mitermayer G Costa, Federico Ristow, Paula |
| description | Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs. |
| doi_str_mv | 10.1371/journal.pntd.0009736 |
| format | Article |
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Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0009736</identifier><identifier>PMID: 34495971</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol ; Animals ; Animals as carriers of disease ; Bacteria ; Biofilms ; Biology and Life Sciences ; Chronic illnesses ; Colonization ; Composition ; Development and progression ; Disease ; Disease Reservoirs - microbiology ; Drinking water ; Gene expression ; Gram-negative bacterial infections ; Health aspects ; Infections ; Kidney - microbiology ; Kidneys ; Leptospira ; Leptospira interrogans ; Leptospira interrogans - genetics ; Leptospira interrogans - physiology ; Leptospirosis ; Leptospirosis - microbiology ; Leptospirosis - veterinary ; Male ; Medicine and Health Sciences ; Microbial mats ; Microscopy ; Occlusion ; Pathogenesis ; Pathogens ; Rats ; Rattus norvegicus ; Renal tubules ; Research and Analysis Methods ; Risk factors ; Rodent Diseases - microbiology ; Slums ; Survival ; Tropical diseases ; Urban environments ; Urine ; Virulence</subject><ispartof>PLoS neglected tropical diseases, 2021-09, Vol.15 (9), p.e0009736-e0009736</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs.</description><subject>Alcohol</subject><subject>Animals</subject><subject>Animals as carriers of disease</subject><subject>Bacteria</subject><subject>Biofilms</subject><subject>Biology and Life Sciences</subject><subject>Chronic illnesses</subject><subject>Colonization</subject><subject>Composition</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Disease Reservoirs - microbiology</subject><subject>Drinking water</subject><subject>Gene expression</subject><subject>Gram-negative bacterial infections</subject><subject>Health aspects</subject><subject>Infections</subject><subject>Kidney - microbiology</subject><subject>Kidneys</subject><subject>Leptospira</subject><subject>Leptospira interrogans</subject><subject>Leptospira interrogans - 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microbiology</topic><topic>Drinking water</topic><topic>Gene expression</topic><topic>Gram-negative bacterial infections</topic><topic>Health aspects</topic><topic>Infections</topic><topic>Kidney - microbiology</topic><topic>Kidneys</topic><topic>Leptospira</topic><topic>Leptospira interrogans</topic><topic>Leptospira interrogans - genetics</topic><topic>Leptospira interrogans - physiology</topic><topic>Leptospirosis</topic><topic>Leptospirosis - microbiology</topic><topic>Leptospirosis - veterinary</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Microbial mats</topic><topic>Microscopy</topic><topic>Occlusion</topic><topic>Pathogenesis</topic><topic>Pathogens</topic><topic>Rats</topic><topic>Rattus norvegicus</topic><topic>Renal tubules</topic><topic>Research and Analysis Methods</topic><topic>Risk factors</topic><topic>Rodent Diseases - microbiology</topic><topic>Slums</topic><topic>Survival</topic><topic>Tropical diseases</topic><topic>Urban environments</topic><topic>Urine</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santos, Ana Amélia Nunes</creatorcontrib><creatorcontrib>Ribeiro, Priscyla Dos Santos</creatorcontrib><creatorcontrib>da França, Geórgia Virgínia</creatorcontrib><creatorcontrib>Souza, Fábio Neves</creatorcontrib><creatorcontrib>Ramos, Eduardo Antônio Gonçalves</creatorcontrib><creatorcontrib>Figueira, Cláudio Pereira</creatorcontrib><creatorcontrib>Reis, Mitermayer G</creatorcontrib><creatorcontrib>Costa, Federico</creatorcontrib><creatorcontrib>Ristow, Paula</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - 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Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34495971</pmid><doi>10.1371/journal.pntd.0009736</doi><orcidid>https://orcid.org/0000-0002-3051-9060</orcidid><orcidid>https://orcid.org/0000-0001-8494-361X</orcidid><orcidid>https://orcid.org/0000-0002-3542-8918</orcidid><orcidid>https://orcid.org/0000-0001-8282-8757</orcidid><orcidid>https://orcid.org/0000-0001-7048-6999</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2021-09, Vol.15 (9), p.e0009736-e0009736 |
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| language | eng |
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| subjects | Alcohol Animals Animals as carriers of disease Bacteria Biofilms Biology and Life Sciences Chronic illnesses Colonization Composition Development and progression Disease Disease Reservoirs - microbiology Drinking water Gene expression Gram-negative bacterial infections Health aspects Infections Kidney - microbiology Kidneys Leptospira Leptospira interrogans Leptospira interrogans - genetics Leptospira interrogans - physiology Leptospirosis Leptospirosis - microbiology Leptospirosis - veterinary Male Medicine and Health Sciences Microbial mats Microscopy Occlusion Pathogenesis Pathogens Rats Rattus norvegicus Renal tubules Research and Analysis Methods Risk factors Rodent Diseases - microbiology Slums Survival Tropical diseases Urban environments Urine Virulence |
| title | Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs |
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