Rift Valley fever virus 78kDa envelope protein attenuates virus replication in macrophage-derived cell lines and viral virulence in mice

Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus with a wide host range including ruminants and humans. RVFV outbreaks have had devastating effects on public health and the livestock industry in African countries. However, there is no approved RVFV vaccine for human use in non-endemic c...

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Veröffentlicht in:	PLoS neglected tropical diseases 2021-09, Vol.15 (9), p.e0009785-e0009785
Hauptverfasser:	Terasaki, Kaori, Kalveram, Birte, Johnson, Kendra N, Juelich, Terry, Smith, Jennifer K, Zhang, Lihong, Freiberg, Alexander N, Makino, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antiviral agents Aquatic insects Attenuation Biology and Life Sciences Bunyaviruses Cell lines Cells Coccidioidomycosis Countries Disease control Drug therapy Fever Genetic aspects Glycoproteins Host range Infectivity Internalization Laboratory animals Levels Livestock Livestock industry Macrophages Macrophages - virology Mammals Medicine and health sciences Membrane proteins Mice Microbiological strains Mortality Mosquitoes Physical Sciences Physiological aspects Prevention Proteins Public health Replication Research and Analysis Methods Rift Valley fever Rift Valley Fever - virology Rift Valley fever virus - pathogenicity Rift Valley fever virus - physiology RNA polymerase Strain Tropical diseases Vaccines Vector-borne diseases Viral diseases Viral envelope proteins Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Viral envelopes Viral vaccines Virions Virulence Virulence (Microbiology) Virus Replication - physiology Virus research Viruses
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