Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study

To investigate the effects of axial length (AL) on the peripapillary microvascular density acquired from optical coherence tomography angiography (OCTA). Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups...

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Veröffentlicht in:PloS one 2021-10, Vol.16 (10), p.e0258479-e0258479
Hauptverfasser: Park, Kee Sup, Lim, Hyung Bin, Shin, Yong Il, Park, Gi Seok, Lee, Woo Hyuk, Kim, Jung-Yeul
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Lee, Woo Hyuk
Kim, Jung-Yeul
description To investigate the effects of axial length (AL) on the peripapillary microvascular density acquired from optical coherence tomography angiography (OCTA). Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups according to the AL: Group 1 (AL: < 24.0 mm; 35 eyes), Group 2 (AL: 24.0-25.99 mm; 37 eyes), and Group 3 (AL: [greater than or equal to] 26 mm; 39 eyes). Peripapillary OCTA images were acquired using 6x 6 mm angiography scans, and vessel density (VD) and perfusion density (PD) of the superficial capillary plexus were calculated automatically. VD and PD were compared among the three groups according to the distance from the optic disc (inner and outer rings). Linear regression analyses were also performed to identify clinical factors associated with average VD. The average ALs of Groups 1-3 were 23.33± 0.57, 25.05± 0.60, and 27.42± 0.82, respectively. Average VD (P = 0.009) and PD (P = 0.029) in the inner ring increased with increasing AL. However, average VD (P < 0.001) and PD (P < 0.001) in the outer ring decreased with AL increased; the same trends were found for the full areas (VD, p
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Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups according to the AL: Group 1 (AL: &lt; 24.0 mm; 35 eyes), Group 2 (AL: 24.0-25.99 mm; 37 eyes), and Group 3 (AL: [greater than or equal to] 26 mm; 39 eyes). Peripapillary OCTA images were acquired using 6x 6 mm angiography scans, and vessel density (VD) and perfusion density (PD) of the superficial capillary plexus were calculated automatically. VD and PD were compared among the three groups according to the distance from the optic disc (inner and outer rings). Linear regression analyses were also performed to identify clinical factors associated with average VD. The average ALs of Groups 1-3 were 23.33± 0.57, 25.05± 0.60, and 27.42± 0.82, respectively. Average VD (P = 0.009) and PD (P = 0.029) in the inner ring increased with increasing AL. However, average VD (P &lt; 0.001) and PD (P &lt; 0.001) in the outer ring decreased with AL increased; the same trends were found for the full areas (VD, p&lt;0.001; PD, p = 0.001). Average VDs in the inner and outer rings were not associated (P = 0.938). Peripapillary VD and PD were significantly associated with AL. Depending on the distance from the disc, peripapillary VDs and PDs of the inner and outer rings were differentially affected by AL. Physicians should therefore consider the effects of AL in the analyses of peripapillary microvasculature.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0258479</identifier><identifier>PMID: 34648529</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Angiography ; Biology and Life Sciences ; Blood vessels ; Coherence (Optics) ; Density ; Diabetes ; Diabetic retinopathy ; Disease ; Engineering and Technology ; Evaluation ; Eye ; Glaucoma ; Hospitals ; Image acquisition ; Information management ; Medical imaging ; Medical schools ; Medical screening ; Medicine ; Medicine and Health Sciences ; Microvasculature ; Observational studies ; Ophthalmology ; Optical Coherence Tomography ; Optics ; Patients ; Perfusion ; Physical Sciences ; Physicians ; Research and Analysis Methods ; Tomography ; Variance analysis</subject><ispartof>PloS one, 2021-10, Vol.16 (10), p.e0258479-e0258479</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Park et al. 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Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups according to the AL: Group 1 (AL: &lt; 24.0 mm; 35 eyes), Group 2 (AL: 24.0-25.99 mm; 37 eyes), and Group 3 (AL: [greater than or equal to] 26 mm; 39 eyes). Peripapillary OCTA images were acquired using 6x 6 mm angiography scans, and vessel density (VD) and perfusion density (PD) of the superficial capillary plexus were calculated automatically. VD and PD were compared among the three groups according to the distance from the optic disc (inner and outer rings). Linear regression analyses were also performed to identify clinical factors associated with average VD. The average ALs of Groups 1-3 were 23.33± 0.57, 25.05± 0.60, and 27.42± 0.82, respectively. Average VD (P = 0.009) and PD (P = 0.029) in the inner ring increased with increasing AL. 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Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups according to the AL: Group 1 (AL: &lt; 24.0 mm; 35 eyes), Group 2 (AL: 24.0-25.99 mm; 37 eyes), and Group 3 (AL: [greater than or equal to] 26 mm; 39 eyes). Peripapillary OCTA images were acquired using 6x 6 mm angiography scans, and vessel density (VD) and perfusion density (PD) of the superficial capillary plexus were calculated automatically. VD and PD were compared among the three groups according to the distance from the optic disc (inner and outer rings). Linear regression analyses were also performed to identify clinical factors associated with average VD. The average ALs of Groups 1-3 were 23.33± 0.57, 25.05± 0.60, and 27.42± 0.82, respectively. Average VD (P = 0.009) and PD (P = 0.029) in the inner ring increased with increasing AL. However, average VD (P &lt; 0.001) and PD (P &lt; 0.001) in the outer ring decreased with AL increased; the same trends were found for the full areas (VD, p&lt;0.001; PD, p = 0.001). Average VDs in the inner and outer rings were not associated (P = 0.938). Peripapillary VD and PD were significantly associated with AL. Depending on the distance from the disc, peripapillary VDs and PDs of the inner and outer rings were differentially affected by AL. Physicians should therefore consider the effects of AL in the analyses of peripapillary microvasculature.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34648529</pmid><doi>10.1371/journal.pone.0258479</doi><tpages>e0258479</tpages><orcidid>https://orcid.org/0000-0003-3679-1310</orcidid><oa>free_for_read</oa></addata></record>
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subjects Angiography
Biology and Life Sciences
Blood vessels
Coherence (Optics)
Density
Diabetes
Diabetic retinopathy
Disease
Engineering and Technology
Evaluation
Eye
Glaucoma
Hospitals
Image acquisition
Information management
Medical imaging
Medical schools
Medical screening
Medicine
Medicine and Health Sciences
Microvasculature
Observational studies
Ophthalmology
Optical Coherence Tomography
Optics
Patients
Perfusion
Physical Sciences
Physicians
Research and Analysis Methods
Tomography
Variance analysis
title Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study
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