Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis
Background Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disea...
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| description | Background Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose. Methods Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers. Results Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17–2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19–2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15–2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72–10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35–2.80, p |
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Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose. Methods Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers. Results Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17–2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19–2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15–2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72–10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35–2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05–2.95, p = 0.032) risk of IF/IL than non-carriers. Conclusion Functional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0258138</identifier><identifier>PMID: 34610045</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Bone loss ; Bone turnover ; Confidence intervals ; Cytokines ; Dental implants ; Dental prosthetics ; Dental restorative materials ; Disease ; Disease control ; Engineering and Technology ; Ethnicity ; Failure ; Gene polymorphism ; Genotype & phenotype ; Genotypes ; Gum disease ; Health risks ; Hospitals ; IL-1β ; Immune response ; Inflammation ; Interleukin ; Interleukin 1 ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Metabolism ; Osseointegration ; Physical Sciences ; Polymorphism ; Research and Analysis Methods ; Risk ; Smoking ; Subgroups ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>PloS one, 2021-10, Vol.16 (10), p.e0258138-e0258138</ispartof><rights>2021 Jin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Jin et al 2021 Jin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-262d06168abfde27e73803568902402dfa19ac5485c9c2e2a0330098e788d4e3</citedby><cites>FETCH-LOGICAL-c503t-262d06168abfde27e73803568902402dfa19ac5485c9c2e2a0330098e788d4e3</cites><orcidid>0000-0003-0870-6342</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491952/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491952/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids></links><search><contributor>Panda, Aditya K.</contributor><creatorcontrib>Jin, Qiuchen</creatorcontrib><creatorcontrib>Teng, Fangjun</creatorcontrib><creatorcontrib>Cheng, Zhigang</creatorcontrib><title>Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis</title><title>PloS one</title><description>Background Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose. Methods Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers. Results Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17–2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19–2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15–2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72–10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35–2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05–2.95, p = 0.032) risk of IF/IL than non-carriers. Conclusion Functional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.</description><subject>Biology and Life Sciences</subject><subject>Bone loss</subject><subject>Bone turnover</subject><subject>Confidence intervals</subject><subject>Cytokines</subject><subject>Dental implants</subject><subject>Dental prosthetics</subject><subject>Dental restorative materials</subject><subject>Disease</subject><subject>Disease control</subject><subject>Engineering and Technology</subject><subject>Ethnicity</subject><subject>Failure</subject><subject>Gene polymorphism</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Gum disease</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>IL-1β</subject><subject>Immune response</subject><subject>Inflammation</subject><subject>Interleukin</subject><subject>Interleukin 1</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metabolism</subject><subject>Osseointegration</subject><subject>Physical Sciences</subject><subject>Polymorphism</subject><subject>Research and Analysis Methods</subject><subject>Risk</subject><subject>Smoking</subject><subject>Subgroups</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis 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between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis</title><author>Jin, Qiuchen ; Teng, Fangjun ; Cheng, Zhigang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-262d06168abfde27e73803568902402dfa19ac5485c9c2e2a0330098e788d4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biology and Life Sciences</topic><topic>Bone loss</topic><topic>Bone turnover</topic><topic>Confidence intervals</topic><topic>Cytokines</topic><topic>Dental implants</topic><topic>Dental prosthetics</topic><topic>Dental restorative materials</topic><topic>Disease</topic><topic>Disease control</topic><topic>Engineering and Technology</topic><topic>Ethnicity</topic><topic>Failure</topic><topic>Gene polymorphism</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Gum disease</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>IL-1β</topic><topic>Immune response</topic><topic>Inflammation</topic><topic>Interleukin</topic><topic>Interleukin 1</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Metabolism</topic><topic>Osseointegration</topic><topic>Physical Sciences</topic><topic>Polymorphism</topic><topic>Research and Analysis Methods</topic><topic>Risk</topic><topic>Smoking</topic><topic>Subgroups</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Qiuchen</creatorcontrib><creatorcontrib>Teng, Fangjun</creatorcontrib><creatorcontrib>Cheng, Zhigang</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Qiuchen</au><au>Teng, Fangjun</au><au>Cheng, Zhigang</au><au>Panda, Aditya K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis</atitle><jtitle>PloS one</jtitle><date>2021-10-01</date><risdate>2021</risdate><volume>16</volume><issue>10</issue><spage>e0258138</spage><epage>e0258138</epage><pages>e0258138-e0258138</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Background Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose. Methods Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers. Results Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17–2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19–2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15–2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72–10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35–2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05–2.95, p = 0.032) risk of IF/IL than non-carriers. Conclusion Functional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34610045</pmid><doi>10.1371/journal.pone.0258138</doi><orcidid>https://orcid.org/0000-0003-0870-6342</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Bone loss Bone turnover Confidence intervals Cytokines Dental implants Dental prosthetics Dental restorative materials Disease Disease control Engineering and Technology Ethnicity Failure Gene polymorphism Genotype & phenotype Genotypes Gum disease Health risks Hospitals IL-1β Immune response Inflammation Interleukin Interleukin 1 Medical research Medicine and Health Sciences Meta-analysis Metabolism Osseointegration Physical Sciences Polymorphism Research and Analysis Methods Risk Smoking Subgroups Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T09%3A47%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20common%20polymorphisms%20in%20IL-1%20and%20TNF%CE%B1%20and%20risk%20of%20peri-implant%20disease:%20A%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Jin,%20Qiuchen&rft.date=2021-10-01&rft.volume=16&rft.issue=10&rft.spage=e0258138&rft.epage=e0258138&rft.pages=e0258138-e0258138&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0258138&rft_dat=%3Cproquest_plos_%3E2579630222%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2579349103&rft_id=info:pmid/34610045&rft_doaj_id=oai_doaj_org_article_366ba717a3254023a3620d6f6474ae75&rfr_iscdi=true |