Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function
Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. W...
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| creator | Ryu, Jung-Hwa Koo, Tai Yeon Ro, Han Cho, Jang-Hee Kim, Myung-Gyu Huh, Kyu Ha Park, Jae Berm Lee, Sik Han, Seungyeup Kim, Jayoun Oh, Kook-Hwan Yang, Jaeseok |
| description | Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1-3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. Furthermore, KT was an independent prognostic factor for better HRQOL. These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar. |
| doi_str_mv | 10.1371/journal.pone.0257981 |
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However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1-3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. Furthermore, KT was an independent prognostic factor for better HRQOL. These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0257981</identifier><identifier>PMID: 34606505</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Biology and Life Sciences ; Cerebrovascular diseases ; Cerebrovascular Disorders - epidemiology ; Chronic kidney failure ; Comorbidity ; Comparative analysis ; Delivery of Health Care ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Employment ; Female ; Follow-Up Studies ; Health aspects ; Health care ; Hemoglobin ; Hemoglobins - analysis ; Higher education ; Hospitals ; Humans ; Income ; Internal medicine ; Kidney - physiopathology ; Kidney diseases ; Kidney Transplantation ; Kidney transplants ; Kidneys ; Laboratories ; Longitudinal Studies ; Male ; Marital Status ; Medical prognosis ; Medical schools ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Morbidity ; Mortality ; Nephrology ; Patient outcomes ; Patient satisfaction ; Patients ; Peritoneal dialysis ; Population ; Prognosis ; Quality of Life ; Questionnaires ; Renal function ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - physiopathology ; Seoul - epidemiology ; Statistical analysis ; Transplant Recipients ; Transplantation ; Variables ; Vascular diseases</subject><ispartof>PloS one, 2021-10, Vol.16 (10), p.e0257981-e0257981</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Ryu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Ryu et al 2021 Ryu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4af1d6b97e3af6824aae62ce8e6d5465807720b162f128a24f71f1a11ec64833</citedby><cites>FETCH-LOGICAL-c692t-4af1d6b97e3af6824aae62ce8e6d5465807720b162f128a24f71f1a11ec64833</cites><orcidid>0000-0002-5378-7797 ; 0000-0001-8807-2452 ; 0000-0002-7561-6534</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489710/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489710/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34606505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryu, Jung-Hwa</creatorcontrib><creatorcontrib>Koo, Tai Yeon</creatorcontrib><creatorcontrib>Ro, Han</creatorcontrib><creatorcontrib>Cho, Jang-Hee</creatorcontrib><creatorcontrib>Kim, Myung-Gyu</creatorcontrib><creatorcontrib>Huh, Kyu Ha</creatorcontrib><creatorcontrib>Park, Jae Berm</creatorcontrib><creatorcontrib>Lee, Sik</creatorcontrib><creatorcontrib>Han, Seungyeup</creatorcontrib><creatorcontrib>Kim, Jayoun</creatorcontrib><creatorcontrib>Oh, Kook-Hwan</creatorcontrib><creatorcontrib>Yang, Jaeseok</creatorcontrib><creatorcontrib>KNOW-KT Study group</creatorcontrib><title>Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1-3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. 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These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar.</description><subject>Adult</subject><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Cerebrovascular diseases</subject><subject>Cerebrovascular Disorders - epidemiology</subject><subject>Chronic kidney failure</subject><subject>Comorbidity</subject><subject>Comparative analysis</subject><subject>Delivery of Health Care</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Employment</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Hemoglobin</subject><subject>Hemoglobins - analysis</subject><subject>Higher education</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Income</subject><subject>Internal medicine</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>Laboratories</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Marital Status</subject><subject>Medical prognosis</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Patient outcomes</subject><subject>Patient satisfaction</subject><subject>Patients</subject><subject>Peritoneal dialysis</subject><subject>Population</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Renal function</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Seoul - epidemiology</subject><subject>Statistical analysis</subject><subject>Transplant Recipients</subject><subject>Transplantation</subject><subject>Variables</subject><subject>Vascular diseases</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9uO0zAQhiMEYpeFN0BgCQnBRYudg5PcIC0rDpVWWglW3FpTZ9y6uHHWdoA-Ay-NQ9OlQXuBcuHI_uYfz--ZJHnK6JxlJXuzsb1rwcw72-KcpkVZV-xecsrqLJ3xlGb3j_5Pkkfebygtsorzh8lJlnPKC1qcJr_eYQjoyBrBhPXMoYGADbnpweiwI1YRoxUS3ZJvumlxR4KD1ncG2kA6CBrb4Im02w5cDAuWyLWzrZYHvNEeweNf9ocOa-L1VhtwxGGsgKi-lUHb9nHyQIHx-GRcz5LrD--vLz7NLq8-Li7OL2eS12mY5aBYw5d1iRkoXqU5APJUYoW8KXJeVLQsU7pkPFUsrSDNVckUA8ZQ8rzKsrPk-V62M9aL0UYvBgdpmeZVEYnFnmgsbETn9BbcTljQ4s-GdSsBLmhpUORULrGOmVNa50UGS0VpXRdQsaJoahi03o7Z-uUWGxlNcGAmotOTVq_Fyn4XVV7VJaNR4NUo4OxNjz6IrfYSTXwCtP3-3lmsmLGIvvgHvbu6kVpBLEC3ysa8chAV57wsq5JndR2p-R1U_Brcahl7Tum4Pwl4PQmITMCfYQW992Lx5fP_s1dfp-zLI3bfp96afugYPwXzPSid9d6hujWZUTGMzMENMYyMGEcmhj07fqDboMOMZL8B-WcTtg</recordid><startdate>20211004</startdate><enddate>20211004</enddate><creator>Ryu, Jung-Hwa</creator><creator>Koo, Tai Yeon</creator><creator>Ro, Han</creator><creator>Cho, Jang-Hee</creator><creator>Kim, Myung-Gyu</creator><creator>Huh, Kyu Ha</creator><creator>Park, Jae Berm</creator><creator>Lee, Sik</creator><creator>Han, Seungyeup</creator><creator>Kim, Jayoun</creator><creator>Oh, Kook-Hwan</creator><creator>Yang, Jaeseok</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5378-7797</orcidid><orcidid>https://orcid.org/0000-0001-8807-2452</orcidid><orcidid>https://orcid.org/0000-0002-7561-6534</orcidid></search><sort><creationdate>20211004</creationdate><title>Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function</title><author>Ryu, Jung-Hwa ; Koo, Tai Yeon ; Ro, Han ; Cho, Jang-Hee ; Kim, Myung-Gyu ; Huh, Kyu Ha ; Park, Jae Berm ; Lee, Sik ; Han, Seungyeup ; Kim, Jayoun ; Oh, Kook-Hwan ; Yang, Jaeseok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4af1d6b97e3af6824aae62ce8e6d5465807720b162f128a24f71f1a11ec64833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Cerebrovascular diseases</topic><topic>Cerebrovascular Disorders - 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However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1-3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. 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| language | eng |
| recordid | cdi_plos_journals_2579072485 |
| source | PLoS; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adult Aged Biology and Life Sciences Cerebrovascular diseases Cerebrovascular Disorders - epidemiology Chronic kidney failure Comorbidity Comparative analysis Delivery of Health Care Diabetes Diabetes mellitus Diabetes Mellitus - epidemiology Employment Female Follow-Up Studies Health aspects Health care Hemoglobin Hemoglobins - analysis Higher education Hospitals Humans Income Internal medicine Kidney - physiopathology Kidney diseases Kidney Transplantation Kidney transplants Kidneys Laboratories Longitudinal Studies Male Marital Status Medical prognosis Medical schools Medicine Medicine and Health Sciences Middle Aged Morbidity Mortality Nephrology Patient outcomes Patient satisfaction Patients Peritoneal dialysis Population Prognosis Quality of Life Questionnaires Renal function Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - physiopathology Seoul - epidemiology Statistical analysis Transplant Recipients Transplantation Variables Vascular diseases |
| title | Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T18%3A23%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Better%20health-related%20quality%20of%20life%20in%20kidney%20transplant%20patients%20compared%20to%20chronic%20kidney%20disease%20patients%20with%20similar%20renal%20function&rft.jtitle=PloS%20one&rft.au=Ryu,%20Jung-Hwa&rft.aucorp=KNOW-KT%20Study%20group&rft.date=2021-10-04&rft.volume=16&rft.issue=10&rft.spage=e0257981&rft.epage=e0257981&rft.pages=e0257981-e0257981&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0257981&rft_dat=%3Cgale_plos_%3EA677876399%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2579072485&rft_id=info:pmid/34606505&rft_galeid=A677876399&rft_doaj_id=oai_doaj_org_article_40cbe9e6d209453abf00995a8155d9a5&rfr_iscdi=true |