An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence

Chemical-genetics (C-G) experiments can be used to identify interactions between inhibitory compounds and bacterial genes, potentially revealing the targets of drugs, or other functionally interacting genes and pathways. C-G experiments involve constructing a library of hypomorphic strains with esse...

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Veröffentlicht in:	PloS one 2021-10, Vol.16 (10), p.e0257911
Hauptverfasser:	Dutta, Esha, DeJesus, Michael A, Ruecker, Nadine, Zaveri, Anisha, Koh, Eun-Ik, Sassetti, Christopher M, Schnappinger, Dirk, Ioerger, Thomas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Analysis Anti-Bacterial Agents - pharmacology Antibiotics Biochemical genetics Biology and Life Sciences Cloning Computer science Depletion Drug Discovery Drug resistance Evaluation Generalized linear models Genes Genes, Bacterial - drug effects Genetics Identification methods Immunology Libraries Medical research Medicine and Health Sciences Mycobacterium tuberculosis - metabolism Next-generation sequencing Outliers (statistics) Physical Sciences Physiology Population Relative abundance Research and Analysis Methods Slopes Statistical analysis Statistical methods Statistics Target recognition Tuberculosis
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