Litter expansion alters metabolic homeostasis in a sex specific manner

Nutritional manipulations early in life have been shown to influence growth rate and elicit long lasting effects which in turn has been found to impact lifespan. Therefore, we studied the long-term effects of pre-weaning dietary restriction implemented by litter expansion (4, 6, 8, 10, and 12 pups p...

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Veröffentlicht in:	PloS one 2021-09, Vol.16 (9), p.e0237199
Hauptverfasser:	Kurup, Kavitha, Mann, Shivani N, Jackson, Jordan, Matyi, Stephanie, Ranjo-Bishop, Michelle, Freeman, Willard M, Stout, Michael B, Richardson, Arlan, Unnikrishnan, Archana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adiponectin - blood Adiponectin - metabolism Adipose Tissue - metabolism Age Aging Analysis Animal models in research Animals Biochemistry Biology and Life Sciences Birth weight Body composition Body fat Brain Cardiovascular disease Cat litter boxes Chronic illnesses Diabetes Diet Dietary restrictions Environmental aspects Expansion Female Fibroblast Growth Factors - blood Fibroblast Growth Factors - metabolism Glucose Glucose tolerance Growth rate Hamm, Harold Health aspects Health sciences Homeostasis Insulin Insulin resistance Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Laboratories Life span Litter Litter Size Liver Long-term effects Male Males Medicine and Health Sciences Metabolic syndrome Mice Mice, Inbred C57BL Molecular biology NMR Nuclear magnetic resonance Nutrition Obesity Organs Pregnancy Proteins Research and Analysis Methods Sex Sex Characteristics Sex Factors Vagina Weaning
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