Predictors of severity and development of critical illness of Egyptian COVID-19 patients: A multicenter study
Objectives We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological characteristics associated with critical illness among patients with COVID-19 from Egypt. Methods The present study was a multicenter, retrospective study that r...
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| creator | Omran, Dalia Al Soda, Mohamed Bahbah, Eshak Esmat, Gamal Shousha, Hend Elgebaly, Ahmed Abdel Ghaffar, Muhammad Alsheikh, Mohamed El Sayed, Enass Afify, Shimaa Abdel Hafez, Samah Elkelany, Khaled Eltayar, Ayman Ali, Omnia Kamal, Lamiaa Heiba, Ahmed |
| description | Objectives We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological characteristics associated with critical illness among patients with COVID-19 from Egypt. Methods The present study was a multicenter, retrospective study that retrieved the data of all Egyptian cases with confirmed COVID-19 admitted to hospitals affiliated to the General Organization for Teaching Hospitals and Institutes (GOTHI) through the period from March to July 2020. The diagnosis of COVID-19 was based on a positive reverse transcription-polymerase chain reaction (RT-PCR) laboratory test. Results This retrospective study included 2724 COVID-19 patients, of whom 423 (15.52%) were critically ill. Approximately 45.86% of the critical group aged above 60 years, compared to 39.59% in the non-critical group (p = 0.016). Multivariate analysis showed that many factors were predictors of critically illness, including age >60 years (OR = 1.30, 95% CI [1.05, 1.61], p = 0.014), low oxygen saturation (OR = 0.93, 95% CI [0.91, 0.95], p |
| doi_str_mv | 10.1371/journal.pone.0256203 |
| format | Article |
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Methods The present study was a multicenter, retrospective study that retrieved the data of all Egyptian cases with confirmed COVID-19 admitted to hospitals affiliated to the General Organization for Teaching Hospitals and Institutes (GOTHI) through the period from March to July 2020. The diagnosis of COVID-19 was based on a positive reverse transcription-polymerase chain reaction (RT-PCR) laboratory test. Results This retrospective study included 2724 COVID-19 patients, of whom 423 (15.52%) were critically ill. Approximately 45.86% of the critical group aged above 60 years, compared to 39.59% in the non-critical group (p = 0.016). Multivariate analysis showed that many factors were predictors of critically illness, including age >60 years (OR = 1.30, 95% CI [1.05, 1.61], p = 0.014), low oxygen saturation (OR = 0.93, 95% CI [0.91, 0.95], p<0.001), low Glasgow coma scale (OR = 0.75, 95% CI [0.67, 0.84], p<0.001), diabetes (OR = 1.62, 95% CI [1.26, 2.08], p<0.001), cancer (OR = 2.47, 95% CI [1.41, 4.35], p = 0.002), and serum ferritin (OR = 1.004, 95% CI [1.0003, 1.008], p = 0.031). Conclusion In the present report, we demonstrated that many factors are associated with COVID-19 critical illness, including older age groups, fatigue, elevated temperature, increased pulse, lower oxygen saturation, the preexistence of diabetes, malignancies, cardiovascular disease, renal diseases, and pulmonary disease. Moreover, elevated serum levels of ALT, AST, and ferritin are associated with worse outcomes. Further studies are required to identify independent predictors of mortality for patients with COVID-19.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0256203</identifier><identifier>PMID: 34555027</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Cardiovascular diseases ; Care and treatment ; Coronaviruses ; COVID-19 ; Critically ill ; Diabetes ; Diabetes mellitus ; Epidemiology ; Ferritin ; High temperature ; Hospitals ; Illnesses ; Infectious diseases ; Laboratory tests ; Lung diseases ; Medical research ; Medicine and Health Sciences ; Mortality ; Multivariate analysis ; Oxygen ; Oxygen content ; Patient outcomes ; Patients ; Physical Sciences ; Polymerase chain reaction ; Reverse transcription ; Saturation ; Serum levels ; Viral diseases</subject><ispartof>PloS one, 2021-09, Vol.16 (9), p.e0256203-e0256203</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Omran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Omran et al 2021 Omran et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-f8d926a8eb64114dd9f2f6908efca14f841a20d0540feb9385cff98ea3477d1c3</citedby><cites>FETCH-LOGICAL-c669t-f8d926a8eb64114dd9f2f6908efca14f841a20d0540feb9385cff98ea3477d1c3</cites><orcidid>0000-0002-5513-6955 ; 0000-0002-5200-5458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459940/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459940/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids></links><search><contributor>Zirlik, Andreas</contributor><creatorcontrib>Omran, Dalia</creatorcontrib><creatorcontrib>Al Soda, Mohamed</creatorcontrib><creatorcontrib>Bahbah, Eshak</creatorcontrib><creatorcontrib>Esmat, Gamal</creatorcontrib><creatorcontrib>Shousha, Hend</creatorcontrib><creatorcontrib>Elgebaly, Ahmed</creatorcontrib><creatorcontrib>Abdel Ghaffar, Muhammad</creatorcontrib><creatorcontrib>Alsheikh, Mohamed</creatorcontrib><creatorcontrib>El Sayed, Enass</creatorcontrib><creatorcontrib>Afify, Shimaa</creatorcontrib><creatorcontrib>Abdel Hafez, Samah</creatorcontrib><creatorcontrib>Elkelany, Khaled</creatorcontrib><creatorcontrib>Eltayar, Ayman</creatorcontrib><creatorcontrib>Ali, Omnia</creatorcontrib><creatorcontrib>Kamal, Lamiaa</creatorcontrib><creatorcontrib>Heiba, Ahmed</creatorcontrib><title>Predictors of severity and development of critical illness of Egyptian COVID-19 patients: A multicenter study</title><title>PloS one</title><description>Objectives We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological characteristics associated with critical illness among patients with COVID-19 from Egypt. Methods The present study was a multicenter, retrospective study that retrieved the data of all Egyptian cases with confirmed COVID-19 admitted to hospitals affiliated to the General Organization for Teaching Hospitals and Institutes (GOTHI) through the period from March to July 2020. The diagnosis of COVID-19 was based on a positive reverse transcription-polymerase chain reaction (RT-PCR) laboratory test. Results This retrospective study included 2724 COVID-19 patients, of whom 423 (15.52%) were critically ill. Approximately 45.86% of the critical group aged above 60 years, compared to 39.59% in the non-critical group (p = 0.016). Multivariate analysis showed that many factors were predictors of critically illness, including age >60 years (OR = 1.30, 95% CI [1.05, 1.61], p = 0.014), low oxygen saturation (OR = 0.93, 95% CI [0.91, 0.95], p<0.001), low Glasgow coma scale (OR = 0.75, 95% CI [0.67, 0.84], p<0.001), diabetes (OR = 1.62, 95% CI [1.26, 2.08], p<0.001), cancer (OR = 2.47, 95% CI [1.41, 4.35], p = 0.002), and serum ferritin (OR = 1.004, 95% CI [1.0003, 1.008], p = 0.031). Conclusion In the present report, we demonstrated that many factors are associated with COVID-19 critical illness, including older age groups, fatigue, elevated temperature, increased pulse, lower oxygen saturation, the preexistence of diabetes, malignancies, cardiovascular disease, renal diseases, and pulmonary disease. Moreover, elevated serum levels of ALT, AST, and ferritin are associated with worse outcomes. Further studies are required to identify independent predictors of mortality for patients with COVID-19.</description><subject>Biology and Life Sciences</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Critically ill</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Epidemiology</subject><subject>Ferritin</subject><subject>High temperature</subject><subject>Hospitals</subject><subject>Illnesses</subject><subject>Infectious diseases</subject><subject>Laboratory tests</subject><subject>Lung diseases</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Oxygen</subject><subject>Oxygen content</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcription</subject><subject>Saturation</subject><subject>Serum levels</subject><subject>Viral 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of severity and development of critical illness of Egyptian COVID-19 patients: A multicenter study</title><author>Omran, Dalia ; Al Soda, Mohamed ; Bahbah, Eshak ; Esmat, Gamal ; Shousha, Hend ; Elgebaly, Ahmed ; Abdel Ghaffar, Muhammad ; Alsheikh, Mohamed ; El Sayed, Enass ; Afify, Shimaa ; Abdel Hafez, Samah ; Elkelany, Khaled ; Eltayar, Ayman ; Ali, Omnia ; Kamal, Lamiaa ; Heiba, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-f8d926a8eb64114dd9f2f6908efca14f841a20d0540feb9385cff98ea3477d1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biology and Life Sciences</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Critically ill</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Epidemiology</topic><topic>Ferritin</topic><topic>High temperature</topic><topic>Hospitals</topic><topic>Illnesses</topic><topic>Infectious diseases</topic><topic>Laboratory tests</topic><topic>Lung diseases</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Oxygen</topic><topic>Oxygen content</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Polymerase chain reaction</topic><topic>Reverse transcription</topic><topic>Saturation</topic><topic>Serum levels</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omran, Dalia</creatorcontrib><creatorcontrib>Al Soda, Mohamed</creatorcontrib><creatorcontrib>Bahbah, Eshak</creatorcontrib><creatorcontrib>Esmat, Gamal</creatorcontrib><creatorcontrib>Shousha, Hend</creatorcontrib><creatorcontrib>Elgebaly, Ahmed</creatorcontrib><creatorcontrib>Abdel Ghaffar, 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omran, Dalia</au><au>Al Soda, Mohamed</au><au>Bahbah, Eshak</au><au>Esmat, Gamal</au><au>Shousha, Hend</au><au>Elgebaly, Ahmed</au><au>Abdel Ghaffar, Muhammad</au><au>Alsheikh, Mohamed</au><au>El Sayed, Enass</au><au>Afify, Shimaa</au><au>Abdel Hafez, Samah</au><au>Elkelany, Khaled</au><au>Eltayar, Ayman</au><au>Ali, Omnia</au><au>Kamal, Lamiaa</au><au>Heiba, Ahmed</au><au>Zirlik, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of severity and development of critical illness of Egyptian COVID-19 patients: A multicenter study</atitle><jtitle>PloS one</jtitle><date>2021-09-23</date><risdate>2021</risdate><volume>16</volume><issue>9</issue><spage>e0256203</spage><epage>e0256203</epage><pages>e0256203-e0256203</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Objectives We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological characteristics associated with critical illness among patients with COVID-19 from Egypt. Methods The present study was a multicenter, retrospective study that retrieved the data of all Egyptian cases with confirmed COVID-19 admitted to hospitals affiliated to the General Organization for Teaching Hospitals and Institutes (GOTHI) through the period from March to July 2020. The diagnosis of COVID-19 was based on a positive reverse transcription-polymerase chain reaction (RT-PCR) laboratory test. Results This retrospective study included 2724 COVID-19 patients, of whom 423 (15.52%) were critically ill. Approximately 45.86% of the critical group aged above 60 years, compared to 39.59% in the non-critical group (p = 0.016). Multivariate analysis showed that many factors were predictors of critically illness, including age >60 years (OR = 1.30, 95% CI [1.05, 1.61], p = 0.014), low oxygen saturation (OR = 0.93, 95% CI [0.91, 0.95], p<0.001), low Glasgow coma scale (OR = 0.75, 95% CI [0.67, 0.84], p<0.001), diabetes (OR = 1.62, 95% CI [1.26, 2.08], p<0.001), cancer (OR = 2.47, 95% CI [1.41, 4.35], p = 0.002), and serum ferritin (OR = 1.004, 95% CI [1.0003, 1.008], p = 0.031). Conclusion In the present report, we demonstrated that many factors are associated with COVID-19 critical illness, including older age groups, fatigue, elevated temperature, increased pulse, lower oxygen saturation, the preexistence of diabetes, malignancies, cardiovascular disease, renal diseases, and pulmonary disease. Moreover, elevated serum levels of ALT, AST, and ferritin are associated with worse outcomes. Further studies are required to identify independent predictors of mortality for patients with COVID-19.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34555027</pmid><doi>10.1371/journal.pone.0256203</doi><tpages>e0256203</tpages><orcidid>https://orcid.org/0000-0002-5513-6955</orcidid><orcidid>https://orcid.org/0000-0002-5200-5458</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_2575815555 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Biology and Life Sciences Cardiovascular diseases Care and treatment Coronaviruses COVID-19 Critically ill Diabetes Diabetes mellitus Epidemiology Ferritin High temperature Hospitals Illnesses Infectious diseases Laboratory tests Lung diseases Medical research Medicine and Health Sciences Mortality Multivariate analysis Oxygen Oxygen content Patient outcomes Patients Physical Sciences Polymerase chain reaction Reverse transcription Saturation Serum levels Viral diseases |
| title | Predictors of severity and development of critical illness of Egyptian COVID-19 patients: A multicenter study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T21%3A55%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predictors%20of%20severity%20and%20development%20of%20critical%20illness%20of%20Egyptian%20COVID-19%20patients:%20A%20multicenter%20study&rft.jtitle=PloS%20one&rft.au=Omran,%20Dalia&rft.date=2021-09-23&rft.volume=16&rft.issue=9&rft.spage=e0256203&rft.epage=e0256203&rft.pages=e0256203-e0256203&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0256203&rft_dat=%3Cgale_plos_%3EA676583882%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2575815555&rft_id=info:pmid/34555027&rft_galeid=A676583882&rft_doaj_id=oai_doaj_org_article_6415293d2d2541d8bd68e5d004da87ec&rfr_iscdi=true |