Prevalence of corneal arcus and associated factors in a German population—Results from the Gutenberg Health Study
We aimed to determine the prevalence of corneal arcus and to identify associated factors in the general population of Germany. The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity,...
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| creator | Wasielica-Poslednik, Joanna Hampel, Ulrike Ries, Lisa Faysal, Ruah Schulz, Andreas Prochaska, Jürgen H Wild, Philipp S Schmidtmann, Irene Münzel, Thomas Beutel, Manfred E Lackner, Karl J Pfeiffer, Norbert Schuster, Alexander K |
| description | We aimed to determine the prevalence of corneal arcus and to identify associated factors in the general population of Germany. The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity, non-contact tonometry and anterior segment imaging were performed for the five-year follow-up examination. Anterior segment photographs were graded for the presence of corneal arcus. Prevalence estimates were computed, and multivariable logistic regression analysis was applied to determine associated factors for corneal arcus including sex, age, spherical equivalent, central corneal thickness, intraocular pressure (IOP), socio-economic status, smoking, BMI, systolic and diastolic arterial blood pressure, HbA1c, HDL-C, LDL-C, triglyceride, and lipid modifying agents. A total of 9,850 right and 9,745 left eyes of 9,858 subjects (59.2±10.8 years), 49.0% females were included in this cross-sectional analysis. 21.1% of men (95%-CI: 20.0%- 22.3%) had a corneal arcus in at least one eye, and 16.9% (95%-CI: 15.9%- 18.0%) of women. In multivariable analyses, the presence of corneal arcus was associated with male gender (OR = 0.54 for female, p |
| doi_str_mv | 10.1371/journal.pone.0255893 |
| format | Article |
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The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity, non-contact tonometry and anterior segment imaging were performed for the five-year follow-up examination. Anterior segment photographs were graded for the presence of corneal arcus. Prevalence estimates were computed, and multivariable logistic regression analysis was applied to determine associated factors for corneal arcus including sex, age, spherical equivalent, central corneal thickness, intraocular pressure (IOP), socio-economic status, smoking, BMI, systolic and diastolic arterial blood pressure, HbA1c, HDL-C, LDL-C, triglyceride, and lipid modifying agents. A total of 9,850 right and 9,745 left eyes of 9,858 subjects (59.2±10.8 years), 49.0% females were included in this cross-sectional analysis. 21.1% of men (95%-CI: 20.0%- 22.3%) had a corneal arcus in at least one eye, and 16.9% (95%-CI: 15.9%- 18.0%) of women. In multivariable analyses, the presence of corneal arcus was associated with male gender (OR = 0.54 for female, p<0.0001), higher age (OR = 2.54 per decade, p<0.0001), smoking (OR = 1.59, p<0.0001), hyperopia (OR = 1.05 per diopter, p<0.0001), thinner cornea (OR = 0.994 per [mu]m, p<0.0001), higher IOP (OR = 1.02, p = 0.039), higher HDL-C-level (OR = 2.13, p<0.0001), higher LDL-C-level (OR = 1.21, p<0.0001), and intake of lipid modifying agents (OR = 1.26, p = 0.0001). Arcus was not associated with socio-economic status, BMI, arterial blood pressure, and HbA1c. Corneal arcus is a frequent alteration of the cornea in Germany and is associated with ocular parameters and systemic parameters of dyslipidemia.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0255893</identifier><identifier>PMID: 34547023</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Acuity ; Analysis ; Biology and Life Sciences ; Blood pressure ; Cardiology ; Care and treatment ; Cholesterol ; Cornea ; Corneal diseases ; Diabetes ; Diagnosis ; Dyslipidemia ; Economics ; Epidemiology ; Ethics ; Eye (anatomy) ; Females ; Gender ; Glycosylated hemoglobin ; High density lipoprotein ; Hyperopia ; Intraocular pressure ; Lipids ; Low density lipoprotein ; Low density lipoproteins ; Medicine and Health Sciences ; Men ; Metabolic disorders ; Methods ; Ophthalmology ; Parameters ; People and places ; Permeability ; Population studies ; Prevalence studies (Epidemiology) ; Preventive medicine ; Psychosomatic medicine ; Regression analysis ; Risk factors ; Segments ; Smoking ; Socioeconomics ; Thrombosis ; Triglycerides ; Visual acuity</subject><ispartof>PloS one, 2021-09, Vol.16 (9), p.e0255893-e0255893</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Wasielica-Poslednik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Wasielica-Poslednik et al 2021 Wasielica-Poslednik et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c618t-733876ed144d716f1985eaca16342c7aae8788a3799c1608cb93ffcb26cfa3223</cites><orcidid>0000-0002-7025-8280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454945/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454945/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids></links><search><contributor>Calabresi, Laura</contributor><creatorcontrib>Wasielica-Poslednik, Joanna</creatorcontrib><creatorcontrib>Hampel, Ulrike</creatorcontrib><creatorcontrib>Ries, Lisa</creatorcontrib><creatorcontrib>Faysal, Ruah</creatorcontrib><creatorcontrib>Schulz, Andreas</creatorcontrib><creatorcontrib>Prochaska, Jürgen H</creatorcontrib><creatorcontrib>Wild, Philipp S</creatorcontrib><creatorcontrib>Schmidtmann, Irene</creatorcontrib><creatorcontrib>Münzel, Thomas</creatorcontrib><creatorcontrib>Beutel, Manfred E</creatorcontrib><creatorcontrib>Lackner, Karl J</creatorcontrib><creatorcontrib>Pfeiffer, Norbert</creatorcontrib><creatorcontrib>Schuster, Alexander K</creatorcontrib><title>Prevalence of corneal arcus and associated factors in a German population—Results from the Gutenberg Health Study</title><title>PloS one</title><description><![CDATA[We aimed to determine the prevalence of corneal arcus and to identify associated factors in the general population of Germany. The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity, non-contact tonometry and anterior segment imaging were performed for the five-year follow-up examination. Anterior segment photographs were graded for the presence of corneal arcus. Prevalence estimates were computed, and multivariable logistic regression analysis was applied to determine associated factors for corneal arcus including sex, age, spherical equivalent, central corneal thickness, intraocular pressure (IOP), socio-economic status, smoking, BMI, systolic and diastolic arterial blood pressure, HbA1c, HDL-C, LDL-C, triglyceride, and lipid modifying agents. A total of 9,850 right and 9,745 left eyes of 9,858 subjects (59.2±10.8 years), 49.0% females were included in this cross-sectional analysis. 21.1% of men (95%-CI: 20.0%- 22.3%) had a corneal arcus in at least one eye, and 16.9% (95%-CI: 15.9%- 18.0%) of women. In multivariable analyses, the presence of corneal arcus was associated with male gender (OR = 0.54 for female, p<0.0001), higher age (OR = 2.54 per decade, p<0.0001), smoking (OR = 1.59, p<0.0001), hyperopia (OR = 1.05 per diopter, p<0.0001), thinner cornea (OR = 0.994 per [mu]m, p<0.0001), higher IOP (OR = 1.02, p = 0.039), higher HDL-C-level (OR = 2.13, p<0.0001), higher LDL-C-level (OR = 1.21, p<0.0001), and intake of lipid modifying agents (OR = 1.26, p = 0.0001). Arcus was not associated with socio-economic status, BMI, arterial blood pressure, and HbA1c. Corneal arcus is a frequent alteration of the cornea in Germany and is associated with ocular parameters and systemic parameters of dyslipidemia.]]></description><subject>Acuity</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Cardiology</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Cornea</subject><subject>Corneal diseases</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Dyslipidemia</subject><subject>Economics</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Eye (anatomy)</subject><subject>Females</subject><subject>Gender</subject><subject>Glycosylated hemoglobin</subject><subject>High density lipoprotein</subject><subject>Hyperopia</subject><subject>Intraocular pressure</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Medicine and Health 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the Gutenberg Health Study</atitle><jtitle>PloS one</jtitle><date>2021-09-21</date><risdate>2021</risdate><volume>16</volume><issue>9</issue><spage>e0255893</spage><epage>e0255893</epage><pages>e0255893-e0255893</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[We aimed to determine the prevalence of corneal arcus and to identify associated factors in the general population of Germany. The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity, non-contact tonometry and anterior segment imaging were performed for the five-year follow-up examination. Anterior segment photographs were graded for the presence of corneal arcus. Prevalence estimates were computed, and multivariable logistic regression analysis was applied to determine associated factors for corneal arcus including sex, age, spherical equivalent, central corneal thickness, intraocular pressure (IOP), socio-economic status, smoking, BMI, systolic and diastolic arterial blood pressure, HbA1c, HDL-C, LDL-C, triglyceride, and lipid modifying agents. A total of 9,850 right and 9,745 left eyes of 9,858 subjects (59.2±10.8 years), 49.0% females were included in this cross-sectional analysis. 21.1% of men (95%-CI: 20.0%- 22.3%) had a corneal arcus in at least one eye, and 16.9% (95%-CI: 15.9%- 18.0%) of women. In multivariable analyses, the presence of corneal arcus was associated with male gender (OR = 0.54 for female, p<0.0001), higher age (OR = 2.54 per decade, p<0.0001), smoking (OR = 1.59, p<0.0001), hyperopia (OR = 1.05 per diopter, p<0.0001), thinner cornea (OR = 0.994 per [mu]m, p<0.0001), higher IOP (OR = 1.02, p = 0.039), higher HDL-C-level (OR = 2.13, p<0.0001), higher LDL-C-level (OR = 1.21, p<0.0001), and intake of lipid modifying agents (OR = 1.26, p = 0.0001). Arcus was not associated with socio-economic status, BMI, arterial blood pressure, and HbA1c. Corneal arcus is a frequent alteration of the cornea in Germany and is associated with ocular parameters and systemic parameters of dyslipidemia.]]></abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34547023</pmid><doi>10.1371/journal.pone.0255893</doi><tpages>e0255893</tpages><orcidid>https://orcid.org/0000-0002-7025-8280</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-09, Vol.16 (9), p.e0255893-e0255893 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2575053566 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acuity Analysis Biology and Life Sciences Blood pressure Cardiology Care and treatment Cholesterol Cornea Corneal diseases Diabetes Diagnosis Dyslipidemia Economics Epidemiology Ethics Eye (anatomy) Females Gender Glycosylated hemoglobin High density lipoprotein Hyperopia Intraocular pressure Lipids Low density lipoprotein Low density lipoproteins Medicine and Health Sciences Men Metabolic disorders Methods Ophthalmology Parameters People and places Permeability Population studies Prevalence studies (Epidemiology) Preventive medicine Psychosomatic medicine Regression analysis Risk factors Segments Smoking Socioeconomics Thrombosis Triglycerides Visual acuity |
| title | Prevalence of corneal arcus and associated factors in a German population—Results from the Gutenberg Health Study |
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