Feedback regulation of Notch signaling and myogenesis connected by MyoD-Dll1 axis

Muscle precursor cells known as myoblasts are essential for muscle development and regeneration. Notch signaling is an ancient intercellular communication mechanism that plays prominent roles in controlling the myogenic program of myoblasts. Currently whether and how the myogenic cues feedback to re...

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Veröffentlicht in:	PLoS genetics 2021-08, Vol.17 (8), p.e1009729-e1009729
Hauptverfasser:	Zhang, Haifeng, Shang, Renjie, Bi, Pengpeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell Culture Techniques Cell Differentiation - genetics Cellular signal transduction CRISPR Feedback Feedback, Physiological - physiology Fibroblasts Gene expression Gene Expression Regulation, Developmental - genetics Genetic aspects Genetic regulation Genetic research Humans Ligands Mammals Medicine and Health Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mice Muscle Development - genetics Muscle Development - physiology Musculoskeletal system Myoblasts Myoblasts - metabolism MyoD protein MyoD Protein - metabolism MyoD Protein - physiology Myogenesis PAX7 Transcription Factor - metabolism Proteins Receptors, Notch - genetics Receptors, Notch - metabolism Research and Analysis Methods Signal Transduction - genetics Stem cells Transcription
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