Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension

To gain insight on the impact of preventive exercise during pulmonary arterial hypertension (PAH), we evaluated the gene expression of myosins and gene-encoding proteins associated with the extracellular matrix remodeling of right hypertrophied ventricles. We used 32 male Wistar rats, separated in f...

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Veröffentlicht in:	PloS one 2021-09, Vol.16 (9), p.e0244768
Hauptverfasser:	Mariano, Thaoan Bruno, de Souza Castilho, Anthony César, de Almeida Sabela, Ana Karenina Dias, de Oliveira, André Casanova, Cury, Sarah Santiloni, Aguiar, Andreo Fernando, Dias, Raisa de Jesus Dutra, Cicogna, Antonio Carlos, Okoshi, Katashi, Junior, Luis Antonio Justulin, Carvalho, Robson Francisco, Pacagnelli, Francis Lopes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Aerobics Analysis Animal sciences Animals Biology Biology and Life Sciences Cardiomyocytes Collagen Collagen (type I) Collagen - genetics Collagen - metabolism Echocardiography Exercise Extracellular matrix Fitness equipment Fractal geometry Gene expression Gene Expression Regulation Genetic aspects Health aspects Heart failure Hypertension Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - prevention & control Hypertrophy Hypertrophy, Right Ventricular - genetics Hypertrophy, Right Ventricular - metabolism Hypertrophy, Right Ventricular - prevention & control Injection Internal medicine Laboratory animals Male Medicine and Health Sciences Messenger RNA Monocrotaline MYH7 gene Myocytes Myosin Myosins - genetics Myosins - metabolism Physical Conditioning, Animal Physical fitness Physical therapy Pulmonary Arterial Hypertension - genetics Pulmonary Arterial Hypertension - metabolism Pulmonary artery Pulmonary hypertension Rats Rats, Wistar Reverse transcription RNA, Messenger - genetics RNA, Messenger - metabolism Sedentary behavior Social Sciences Training Treadmills Velocity Zoology
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