Human placental perfusion measured using dynamic contrast enhancement MRI
To evaluate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and measure values of in vivo placental perfusion in women. This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before terminatio...
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| creator | Deloison, Benjamin Arthuis, Chloé Benchimol, Gabriel Balvay, Daniel Bussieres, Laurence Millischer, Anne-Elodie Grévent, David Butor, Cécile Chalouhi, Gihad Mahallati, Houman Hélénon, Olivier Tavitian, Bertrand Clement, Olivier Ville, Yves Siauve, Nathalie Salomon, Laurent Julien |
| description | To evaluate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and measure values of in vivo placental perfusion in women. This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses. 134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F .sub.total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA. Measuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies. |
| doi_str_mv | 10.1371/journal.pone.0256769 |
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This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses. 134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F .sub.total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA. Measuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0256769</identifier><identifier>PMID: 34473740</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Blood ; Blood flow ; Computer and Information Sciences ; Engineering and Technology ; Evaluation ; Fetuses ; Gadolinium ; Gestational age ; In vivo methods and tests ; Karyotypes ; Life Sciences ; Magnetic resonance ; Magnetic resonance imaging ; Medicine and Health Sciences ; Morphology ; Noise ; Parameters ; Perfusion ; Placenta ; Placental hormones ; Pregnancy ; Quality control ; Research and Analysis Methods ; Ultrasonic imaging ; Veins & arteries</subject><ispartof>PloS one, 2021-09, Vol.16 (9), p.e0256769-e0256769</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Deloison et al. 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This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses. 134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F .sub.total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA. Measuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies.</description><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood flow</subject><subject>Computer and Information Sciences</subject><subject>Engineering and Technology</subject><subject>Evaluation</subject><subject>Fetuses</subject><subject>Gadolinium</subject><subject>Gestational age</subject><subject>In vivo methods and tests</subject><subject>Karyotypes</subject><subject>Life Sciences</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Medicine and Health Sciences</subject><subject>Morphology</subject><subject>Noise</subject><subject>Parameters</subject><subject>Perfusion</subject><subject>Placenta</subject><subject>Placental 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placental perfusion measured using dynamic contrast enhancement MRI</title><author>Deloison, Benjamin ; Arthuis, Chloé ; Benchimol, Gabriel ; Balvay, Daniel ; Bussieres, Laurence ; Millischer, Anne-Elodie ; Grévent, David ; Butor, Cécile ; Chalouhi, Gihad ; Mahallati, Houman ; Hélénon, Olivier ; Tavitian, Bertrand ; Clement, Olivier ; Ville, Yves ; Siauve, Nathalie ; Salomon, Laurent Julien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c703t-dbf6c9dee6c35c15b0688ec2273d714c73c8bea0fb571dda0a5c50bddad4937a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood flow</topic><topic>Computer and Information Sciences</topic><topic>Engineering and Technology</topic><topic>Evaluation</topic><topic>Fetuses</topic><topic>Gadolinium</topic><topic>Gestational age</topic><topic>In vivo methods and 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vivo placental perfusion in women. This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses. 134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F .sub.total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA. Measuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34473740</pmid><doi>10.1371/journal.pone.0256769</doi><tpages>e0256769</tpages><orcidid>https://orcid.org/0000-0002-3302-416X</orcidid><orcidid>https://orcid.org/0000-0002-7937-3648</orcidid><orcidid>https://orcid.org/0000-0002-5349-8194</orcidid><orcidid>https://orcid.org/0000-0002-6890-671X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2021-09, Vol.16 (9), p.e0256769-e0256769 |
| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Biology and Life Sciences Blood Blood flow Computer and Information Sciences Engineering and Technology Evaluation Fetuses Gadolinium Gestational age In vivo methods and tests Karyotypes Life Sciences Magnetic resonance Magnetic resonance imaging Medicine and Health Sciences Morphology Noise Parameters Perfusion Placenta Placental hormones Pregnancy Quality control Research and Analysis Methods Ultrasonic imaging Veins & arteries |
| title | Human placental perfusion measured using dynamic contrast enhancement MRI |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T09%3A02%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20placental%20perfusion%20measured%20using%20dynamic%20contrast%20enhancement%20MRI&rft.jtitle=PloS%20one&rft.au=Deloison,%20Benjamin&rft.date=2021-09-02&rft.volume=16&rft.issue=9&rft.spage=e0256769&rft.epage=e0256769&rft.pages=e0256769-e0256769&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0256769&rft_dat=%3Cgale_plos_%3EA674089508%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2568584523&rft_id=info:pmid/34473740&rft_galeid=A674089508&rft_doaj_id=oai_doaj_org_article_ebaaca519f4f4a029978625e8a9d787a&rfr_iscdi=true |