Ankle joint rotation and exerted moment during plantarflexion dependents on measuring- and fixation method

We examined the effect of ankle joint fixation vs increased foot pressure (aiming to reduce dynamometer-subject elasticity (DSE)) on the exerted moment during plantarflexion contraction. We also examined the joint rotation in dependence of the measuring site (forefoot, rearfoot) and the foot conditi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2021-08, Vol.16 (8), p.e0253015-e0253015
Hauptverfasser: Stafilidis, Savvas, Kopper-Zisser, Carina
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page e0253015
container_issue 8
container_start_page e0253015
container_title PloS one
container_volume 16
creator Stafilidis, Savvas
Kopper-Zisser, Carina
description We examined the effect of ankle joint fixation vs increased foot pressure (aiming to reduce dynamometer-subject elasticity (DSE)) on the exerted moment during plantarflexion contraction. We also examined the joint rotation in dependence of the measuring site (forefoot, rearfoot) and the foot condition (fixed, free). We hypothesized higher exerted moments due to reduced DSE compared to fixed condition and an effect of fixation on the joint rotation in dependence of the measuring site. Fourteen healthy individuals (28.7±6.9y) completed in randomized order maximal isometric plantarflexions in four different positions (0-3-6-9 cm) and two ankle joint conditions (fixed-free). Kinematics of the rear- and forefoot were obtained synchronously. We found higher moment in the fixed compared to the free condition at all positions. The maximum moment in the fixed condition did not differ at any position. At the fixed condition, the forefoot rotation did not differ at any position (~5°) while at free condition we observed a significant rotation reduction (form ~12 to ~5°). The rearfoot rotation did not differ between conditions at any position while a significant joint angle reduction was observed (~10 to ~6° and ~12 to ~6°; fixed-free respectively). The results indicate that with appropriate foot fixation the maximum moment can be achieved irrespective of the position. With the foot secured, the measuring site influences the rotational outcome. We suggest that for a minimization of the joint rotation a fixation and the forefoot-measuring site should be preferred. Additionally, for unconstrained foot kinematic observations both measuring sites can be obtained.
doi_str_mv 10.1371/journal.pone.0253015
format Article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2567969520</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A673834703</galeid><doaj_id>oai_doaj_org_article_a1c65629043540a7ab56f2fc6d26e996</doaj_id><sourcerecordid>A673834703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c669t-969293713bb2a3365deb6b86d369d2f2340af31ec3cd07b2b743a753497b95093</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7jr6DwQLguhFxzSnSSc3wrD4MbCw4NdtSJvTmYxtM5ukMv5705kqW9kLyUU-zpP35LzkJMnznCxzKPO3ezu4XrXLg-1xSSgDkrMHyWUugGacEnh4Z32RPPF-TwiDFeePkwsoCl6AIJfJft3_aDHdW9OH1NmggrF9qnqd4hFdQJ12tsMY04Mz_TY9tKoPyjUtHkdQ4wF7HeM-jbsOlT9h2UmhMcezXIdhZ_XT5FGjWo_PpnmRfPvw_uvVp-z65uPman2d1ZyLkAkuqIgFQlVRBcCZxopXK66BC00bCgVRDeRYQ61JWdGqLECVDApRVoIRAYvkxVn30FovJ5u8pIyXUZtFOxbJ5kxoq_by4Eyn3C9plZGnA-u2Urlg6halymvOOBWkABYTl6pivKFNzTXlKASPWu-mbEPVoa6jF061M9F5pDc7ubU_5aogJePjc19PAs7eDuiD7IyvsY1Gox1O715RVjCAiL78B72_uonaqliA6Rsb89ajqFzzElZQlGTUWt5DxaGxM3X8U42J57MLb2YXIhPwGLZq8F5uvnz-f_bm-5x9dYfdoWrDztt2GH-On4PFGayd9d5h89fknMixJf64IceWkFNLwG96VfyP</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2567969520</pqid></control><display><type>article</type><title>Ankle joint rotation and exerted moment during plantarflexion dependents on measuring- and fixation method</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Stafilidis, Savvas ; Kopper-Zisser, Carina</creator><creatorcontrib>Stafilidis, Savvas ; Kopper-Zisser, Carina</creatorcontrib><description>We examined the effect of ankle joint fixation vs increased foot pressure (aiming to reduce dynamometer-subject elasticity (DSE)) on the exerted moment during plantarflexion contraction. We also examined the joint rotation in dependence of the measuring site (forefoot, rearfoot) and the foot condition (fixed, free). We hypothesized higher exerted moments due to reduced DSE compared to fixed condition and an effect of fixation on the joint rotation in dependence of the measuring site. Fourteen healthy individuals (28.7±6.9y) completed in randomized order maximal isometric plantarflexions in four different positions (0-3-6-9 cm) and two ankle joint conditions (fixed-free). Kinematics of the rear- and forefoot were obtained synchronously. We found higher moment in the fixed compared to the free condition at all positions. The maximum moment in the fixed condition did not differ at any position. At the fixed condition, the forefoot rotation did not differ at any position (~5°) while at free condition we observed a significant rotation reduction (form ~12 to ~5°). The rearfoot rotation did not differ between conditions at any position while a significant joint angle reduction was observed (~10 to ~6° and ~12 to ~6°; fixed-free respectively). The results indicate that with appropriate foot fixation the maximum moment can be achieved irrespective of the position. With the foot secured, the measuring site influences the rotational outcome. We suggest that for a minimization of the joint rotation a fixation and the forefoot-measuring site should be preferred. Additionally, for unconstrained foot kinematic observations both measuring sites can be obtained.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0253015</identifier><identifier>PMID: 34464390</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Ankle ; Biology and Life Sciences ; Biomechanics ; Computer science ; Contraction ; Engineering and Technology ; Feet ; Fixation ; Foot ; Informed consent ; Isometric ; Kinematics ; Kinesiology ; Medicine and Health Sciences ; Morphology ; Movements ; Physical Sciences ; Physiological aspects ; Position measurement ; Reduction ; Rotation ; Sport science</subject><ispartof>PloS one, 2021-08, Vol.16 (8), p.e0253015-e0253015</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Stafilidis, Kopper-Zisser. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Stafilidis, Kopper-Zisser 2021 Stafilidis, Kopper-Zisser</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-969293713bb2a3365deb6b86d369d2f2340af31ec3cd07b2b743a753497b95093</citedby><cites>FETCH-LOGICAL-c669t-969293713bb2a3365deb6b86d369d2f2340af31ec3cd07b2b743a753497b95093</cites><orcidid>0000-0003-3960-1551</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407569/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407569/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids></links><search><creatorcontrib>Stafilidis, Savvas</creatorcontrib><creatorcontrib>Kopper-Zisser, Carina</creatorcontrib><title>Ankle joint rotation and exerted moment during plantarflexion dependents on measuring- and fixation method</title><title>PloS one</title><description>We examined the effect of ankle joint fixation vs increased foot pressure (aiming to reduce dynamometer-subject elasticity (DSE)) on the exerted moment during plantarflexion contraction. We also examined the joint rotation in dependence of the measuring site (forefoot, rearfoot) and the foot condition (fixed, free). We hypothesized higher exerted moments due to reduced DSE compared to fixed condition and an effect of fixation on the joint rotation in dependence of the measuring site. Fourteen healthy individuals (28.7±6.9y) completed in randomized order maximal isometric plantarflexions in four different positions (0-3-6-9 cm) and two ankle joint conditions (fixed-free). Kinematics of the rear- and forefoot were obtained synchronously. We found higher moment in the fixed compared to the free condition at all positions. The maximum moment in the fixed condition did not differ at any position. At the fixed condition, the forefoot rotation did not differ at any position (~5°) while at free condition we observed a significant rotation reduction (form ~12 to ~5°). The rearfoot rotation did not differ between conditions at any position while a significant joint angle reduction was observed (~10 to ~6° and ~12 to ~6°; fixed-free respectively). The results indicate that with appropriate foot fixation the maximum moment can be achieved irrespective of the position. With the foot secured, the measuring site influences the rotational outcome. We suggest that for a minimization of the joint rotation a fixation and the forefoot-measuring site should be preferred. Additionally, for unconstrained foot kinematic observations both measuring sites can be obtained.</description><subject>Ankle</subject><subject>Biology and Life Sciences</subject><subject>Biomechanics</subject><subject>Computer science</subject><subject>Contraction</subject><subject>Engineering and Technology</subject><subject>Feet</subject><subject>Fixation</subject><subject>Foot</subject><subject>Informed consent</subject><subject>Isometric</subject><subject>Kinematics</subject><subject>Kinesiology</subject><subject>Medicine and Health Sciences</subject><subject>Morphology</subject><subject>Movements</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Position measurement</subject><subject>Reduction</subject><subject>Rotation</subject><subject>Sport science</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7jr6DwQLguhFxzSnSSc3wrD4MbCw4NdtSJvTmYxtM5ukMv5705kqW9kLyUU-zpP35LzkJMnznCxzKPO3ezu4XrXLg-1xSSgDkrMHyWUugGacEnh4Z32RPPF-TwiDFeePkwsoCl6AIJfJft3_aDHdW9OH1NmggrF9qnqd4hFdQJ12tsMY04Mz_TY9tKoPyjUtHkdQ4wF7HeM-jbsOlT9h2UmhMcezXIdhZ_XT5FGjWo_PpnmRfPvw_uvVp-z65uPman2d1ZyLkAkuqIgFQlVRBcCZxopXK66BC00bCgVRDeRYQ61JWdGqLECVDApRVoIRAYvkxVn30FovJ5u8pIyXUZtFOxbJ5kxoq_by4Eyn3C9plZGnA-u2Urlg6halymvOOBWkABYTl6pivKFNzTXlKASPWu-mbEPVoa6jF061M9F5pDc7ubU_5aogJePjc19PAs7eDuiD7IyvsY1Gox1O715RVjCAiL78B72_uonaqliA6Rsb89ajqFzzElZQlGTUWt5DxaGxM3X8U42J57MLb2YXIhPwGLZq8F5uvnz-f_bm-5x9dYfdoWrDztt2GH-On4PFGayd9d5h89fknMixJf64IceWkFNLwG96VfyP</recordid><startdate>20210831</startdate><enddate>20210831</enddate><creator>Stafilidis, Savvas</creator><creator>Kopper-Zisser, Carina</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3960-1551</orcidid></search><sort><creationdate>20210831</creationdate><title>Ankle joint rotation and exerted moment during plantarflexion dependents on measuring- and fixation method</title><author>Stafilidis, Savvas ; Kopper-Zisser, Carina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-969293713bb2a3365deb6b86d369d2f2340af31ec3cd07b2b743a753497b95093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ankle</topic><topic>Biology and Life Sciences</topic><topic>Biomechanics</topic><topic>Computer science</topic><topic>Contraction</topic><topic>Engineering and Technology</topic><topic>Feet</topic><topic>Fixation</topic><topic>Foot</topic><topic>Informed consent</topic><topic>Isometric</topic><topic>Kinematics</topic><topic>Kinesiology</topic><topic>Medicine and Health Sciences</topic><topic>Morphology</topic><topic>Movements</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Position measurement</topic><topic>Reduction</topic><topic>Rotation</topic><topic>Sport science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stafilidis, Savvas</creatorcontrib><creatorcontrib>Kopper-Zisser, Carina</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stafilidis, Savvas</au><au>Kopper-Zisser, Carina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ankle joint rotation and exerted moment during plantarflexion dependents on measuring- and fixation method</atitle><jtitle>PloS one</jtitle><date>2021-08-31</date><risdate>2021</risdate><volume>16</volume><issue>8</issue><spage>e0253015</spage><epage>e0253015</epage><pages>e0253015-e0253015</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We examined the effect of ankle joint fixation vs increased foot pressure (aiming to reduce dynamometer-subject elasticity (DSE)) on the exerted moment during plantarflexion contraction. We also examined the joint rotation in dependence of the measuring site (forefoot, rearfoot) and the foot condition (fixed, free). We hypothesized higher exerted moments due to reduced DSE compared to fixed condition and an effect of fixation on the joint rotation in dependence of the measuring site. Fourteen healthy individuals (28.7±6.9y) completed in randomized order maximal isometric plantarflexions in four different positions (0-3-6-9 cm) and two ankle joint conditions (fixed-free). Kinematics of the rear- and forefoot were obtained synchronously. We found higher moment in the fixed compared to the free condition at all positions. The maximum moment in the fixed condition did not differ at any position. At the fixed condition, the forefoot rotation did not differ at any position (~5°) while at free condition we observed a significant rotation reduction (form ~12 to ~5°). The rearfoot rotation did not differ between conditions at any position while a significant joint angle reduction was observed (~10 to ~6° and ~12 to ~6°; fixed-free respectively). The results indicate that with appropriate foot fixation the maximum moment can be achieved irrespective of the position. With the foot secured, the measuring site influences the rotational outcome. We suggest that for a minimization of the joint rotation a fixation and the forefoot-measuring site should be preferred. Additionally, for unconstrained foot kinematic observations both measuring sites can be obtained.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34464390</pmid><doi>10.1371/journal.pone.0253015</doi><tpages>e0253015</tpages><orcidid>https://orcid.org/0000-0003-3960-1551</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2021-08, Vol.16 (8), p.e0253015-e0253015
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2567969520
source DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS)
subjects Ankle
Biology and Life Sciences
Biomechanics
Computer science
Contraction
Engineering and Technology
Feet
Fixation
Foot
Informed consent
Isometric
Kinematics
Kinesiology
Medicine and Health Sciences
Morphology
Movements
Physical Sciences
Physiological aspects
Position measurement
Reduction
Rotation
Sport science
title Ankle joint rotation and exerted moment during plantarflexion dependents on measuring- and fixation method
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T23%3A07%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ankle%20joint%20rotation%20and%20exerted%20moment%20during%20plantarflexion%20dependents%20on%20measuring-%20and%20fixation%20method&rft.jtitle=PloS%20one&rft.au=Stafilidis,%20Savvas&rft.date=2021-08-31&rft.volume=16&rft.issue=8&rft.spage=e0253015&rft.epage=e0253015&rft.pages=e0253015-e0253015&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0253015&rft_dat=%3Cgale_plos_%3EA673834703%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2567969520&rft_id=info:pmid/34464390&rft_galeid=A673834703&rft_doaj_id=oai_doaj_org_article_a1c65629043540a7ab56f2fc6d26e996&rfr_iscdi=true