Impact of HLA type, age and chronic viral infection on peripheral T-cell receptor sharing between unrelated individuals

The human adaptive immune system must generate extraordinary diversity to be able to respond to all possible pathogens. The T-cell repertoire derives this high diversity through somatic recombination of the T-cell receptor (TCR) locus, a random process that results in repertoires that are largely pr...

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Veröffentlicht in:	PloS one 2021-08, Vol.16 (8), p.e0249484-e0249484
Hauptverfasser:	Johnson, Sarah A, Seale, Spencer L, Gittelman, Rachel M, Rytlewski, Julie A, Robins, Harlan S, Fields, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive systems Age Alleles Analysis Antigens Biology and Life Sciences Cell proliferation Chronic infection Cloning Correlation Exposure Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens Immune system Influence Lymphocytes Lymphocytes T Medicine and Health Sciences Pathogens Random processes Receptors Recombination Research and Analysis Methods Severe acute respiratory syndrome coronavirus 2 T cell receptors T cells T-cell receptor Thymus Variable region
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