Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer
The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca). We retrospectively a...
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| Veröffentlicht in: | PloS one 2021-08, Vol.16 (8), p.e0256797-e0256797 |
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| creator | Matsueda, Katsunori Kanzaki, Hiromitsu Takenaka, Ryuta Nakagawa, Masahiro Matsueda, Kazuhiro Iwamuro, Masaya Kawano, Seiji Kawahara, Yoshiro Toji, Tomohiro Tanaka, Takehiro Yagi, Takahito Fujiwara, Toshiyoshi Okada, Hiroyuki |
| description | The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).
We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.
Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).
SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca. |
| doi_str_mv | 10.1371/journal.pone.0256797 |
| format | Article |
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We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.
Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).
SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0256797</identifier><identifier>PMID: 34449813</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Ampulla of Vater - diagnostic imaging ; Ampulla of Vater - pathology ; Biology and Life Sciences ; Cancer ; Carcinoma ; Carcinoma - diagnosis ; Carcinoma - diagnostic imaging ; Carcinoma - epidemiology ; Carcinoma - pathology ; Colorectal cancer ; Dentistry ; Diagnosis ; Duodenal Neoplasms - diagnosis ; Duodenal Neoplasms - epidemiology ; Duodenal Neoplasms - genetics ; Duodenal Neoplasms - pathology ; Endoscopy ; Ethics ; Female ; Gastric cancer ; Gastroenterology ; Gastrointestinal cancer ; Hepatology ; Humans ; Identification and classification ; Intestinal Mucosa - diagnostic imaging ; Intestinal Mucosa - pathology ; Intestine ; Invasiveness ; Lesions ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mucin ; Mucins - genetics ; Mucosa ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - pathology ; Pathology ; Patients ; Pharmaceutical sciences ; Phenotype ; Phenotypes ; Small intestine cancer ; Surgery ; Tumors ; University graduates</subject><ispartof>PloS one, 2021-08, Vol.16 (8), p.e0256797-e0256797</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Matsueda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Matsueda et al 2021 Matsueda et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c685t-c02d13eb50baf522c8e677d4654d0ef9312473a23d20c63e3efaf0b7b7facb333</cites><orcidid>0000-0002-0509-251X ; 0000-0002-6497-730X ; 0000-0002-0545-8892</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396771/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396771/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34449813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsueda, Katsunori</creatorcontrib><creatorcontrib>Kanzaki, Hiromitsu</creatorcontrib><creatorcontrib>Takenaka, Ryuta</creatorcontrib><creatorcontrib>Nakagawa, Masahiro</creatorcontrib><creatorcontrib>Matsueda, Kazuhiro</creatorcontrib><creatorcontrib>Iwamuro, Masaya</creatorcontrib><creatorcontrib>Kawano, Seiji</creatorcontrib><creatorcontrib>Kawahara, Yoshiro</creatorcontrib><creatorcontrib>Toji, Tomohiro</creatorcontrib><creatorcontrib>Tanaka, Takehiro</creatorcontrib><creatorcontrib>Yagi, Takahito</creatorcontrib><creatorcontrib>Fujiwara, Toshiyoshi</creatorcontrib><creatorcontrib>Okada, Hiroyuki</creatorcontrib><title>Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).
We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.
Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).
SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ampulla of Vater - diagnostic imaging</subject><subject>Ampulla of Vater - pathology</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - epidemiology</subject><subject>Carcinoma - pathology</subject><subject>Colorectal cancer</subject><subject>Dentistry</subject><subject>Diagnosis</subject><subject>Duodenal Neoplasms - diagnosis</subject><subject>Duodenal Neoplasms - epidemiology</subject><subject>Duodenal Neoplasms - genetics</subject><subject>Duodenal Neoplasms - pathology</subject><subject>Endoscopy</subject><subject>Ethics</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>Gastrointestinal cancer</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Intestinal Mucosa - diagnostic imaging</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestine</subject><subject>Invasiveness</subject><subject>Lesions</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mucin</subject><subject>Mucins - genetics</subject><subject>Mucosa</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Pathology</subject><subject>Patients</subject><subject>Pharmaceutical sciences</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Small intestine cancer</subject><subject>Surgery</subject><subject>Tumors</subject><subject>University graduates</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLguhFx7Rp0_ZGWAY_BhYW_LoNp_mYydgm3aQd3H_vmZnuMpW9kF60nDznTd43PVH0MiWLlJbph60bvYV20TurFiQrWFmXj6LztKZZwjJCH598n0XPQtgSUtCKsafRGc3zvK5Seh79XrbGGgFtDFbG_UZZN9z2h4LYgAcxKG_CYESInY7D2HSjcAFXjd1BMDsVC_DCWNcBlmLrbAJdP7Yt-NtYjk4qu5cCK5R_Hj3R0Ab1YnpfRD8_f_qx_JpcXX9ZLS-vEsGqYkgEyWRKVVOQBnSRZaJSrCxlzopcEqVrmmZ5SSGjMiOCUUWVBk2asik1iIZSehG9Pur2rQt8yilwjKhA29iLxOpISAdb3nvT4XG5A8MPBefXHDyabhXXBZMilTWQJs9FU1UCirosCRQNAaY1an2cdsNwlBTKDh7ameh8xZoNX7sdr2iNvlIUeDcJeHczqjDwzgShMEKr3Hg4NyO0Igdnb_5BH3Y3UWtAA8Zqh_uKvSi_ZCXePf4pDKnFAxQ-UnVG4E-lDdZnDe9nDcgM6s-whjEEvvr-7f_Z619z9u0Ju1HQDpvg2nEwzoY5mB9B4V0IXun7kFPC9zNxlwbfzwSfZgLbXp1e0H3T3RDQv3bNCZI</recordid><startdate>20210827</startdate><enddate>20210827</enddate><creator>Matsueda, Katsunori</creator><creator>Kanzaki, Hiromitsu</creator><creator>Takenaka, Ryuta</creator><creator>Nakagawa, Masahiro</creator><creator>Matsueda, Kazuhiro</creator><creator>Iwamuro, Masaya</creator><creator>Kawano, Seiji</creator><creator>Kawahara, Yoshiro</creator><creator>Toji, Tomohiro</creator><creator>Tanaka, Takehiro</creator><creator>Yagi, Takahito</creator><creator>Fujiwara, Toshiyoshi</creator><creator>Okada, Hiroyuki</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0509-251X</orcidid><orcidid>https://orcid.org/0000-0002-6497-730X</orcidid><orcidid>https://orcid.org/0000-0002-0545-8892</orcidid></search><sort><creationdate>20210827</creationdate><title>Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer</title><author>Matsueda, Katsunori ; Kanzaki, Hiromitsu ; Takenaka, Ryuta ; Nakagawa, Masahiro ; Matsueda, Kazuhiro ; Iwamuro, Masaya ; Kawano, Seiji ; Kawahara, Yoshiro ; Toji, Tomohiro ; Tanaka, Takehiro ; Yagi, Takahito ; Fujiwara, Toshiyoshi ; Okada, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-c02d13eb50baf522c8e677d4654d0ef9312473a23d20c63e3efaf0b7b7facb333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ampulla of Vater - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsueda, Katsunori</au><au>Kanzaki, Hiromitsu</au><au>Takenaka, Ryuta</au><au>Nakagawa, Masahiro</au><au>Matsueda, Kazuhiro</au><au>Iwamuro, Masaya</au><au>Kawano, Seiji</au><au>Kawahara, Yoshiro</au><au>Toji, Tomohiro</au><au>Tanaka, Takehiro</au><au>Yagi, Takahito</au><au>Fujiwara, Toshiyoshi</au><au>Okada, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-08-27</date><risdate>2021</risdate><volume>16</volume><issue>8</issue><spage>e0256797</spage><epage>e0256797</epage><pages>e0256797-e0256797</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).
We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.
Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).
SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34449813</pmid><doi>10.1371/journal.pone.0256797</doi><tpages>e0256797</tpages><orcidid>https://orcid.org/0000-0002-0509-251X</orcidid><orcidid>https://orcid.org/0000-0002-6497-730X</orcidid><orcidid>https://orcid.org/0000-0002-0545-8892</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-08, Vol.16 (8), p.e0256797-e0256797 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2565449473 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Aged, 80 and over Ampulla of Vater - diagnostic imaging Ampulla of Vater - pathology Biology and Life Sciences Cancer Carcinoma Carcinoma - diagnosis Carcinoma - diagnostic imaging Carcinoma - epidemiology Carcinoma - pathology Colorectal cancer Dentistry Diagnosis Duodenal Neoplasms - diagnosis Duodenal Neoplasms - epidemiology Duodenal Neoplasms - genetics Duodenal Neoplasms - pathology Endoscopy Ethics Female Gastric cancer Gastroenterology Gastrointestinal cancer Hepatology Humans Identification and classification Intestinal Mucosa - diagnostic imaging Intestinal Mucosa - pathology Intestine Invasiveness Lesions Male Medicine Medicine and Health Sciences Middle Aged Mucin Mucins - genetics Mucosa Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Pathology Patients Pharmaceutical sciences Phenotype Phenotypes Small intestine cancer Surgery Tumors University graduates |
| title | Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T18%3A04%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20and%20phenotypical%20characteristics%20of%20submucosal%20invasive%20carcinoma%20in%20non-ampullary%20duodenal%20cancer&rft.jtitle=PloS%20one&rft.au=Matsueda,%20Katsunori&rft.date=2021-08-27&rft.volume=16&rft.issue=8&rft.spage=e0256797&rft.epage=e0256797&rft.pages=e0256797-e0256797&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0256797&rft_dat=%3Cgale_plos_%3EA673447976%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2565449473&rft_id=info:pmid/34449813&rft_galeid=A673447976&rft_doaj_id=oai_doaj_org_article_f56dc1d9a0b44cb88ca59770a5b0a6ff&rfr_iscdi=true |