Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome
Adipokine leptin plays a crucial role in metabolic and reproductive functions. Leptin receptor has a soluble form that binds to leptin, thus modulating its level in the circulation. It has been indicated that the levels of leptin and leptin receptor and also LEP rs7799039 and LEPR rs1137101 polymorp...
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| Veröffentlicht in: | PloS one 2021-08, Vol.16 (8), p.e0255920 |
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| creator | Kargasheh, Fatemeh Bagheri Ansaripour, Soheila Borumandnia, Nasrin Moradi, Nariman Zandieh, Zahra Maleki, Monireh Mokhtar, Sara Karimi, Atousa Fatemi, Farnaz Kheirollahi, Asma Vatannejad, Akram |
| description | Adipokine leptin plays a crucial role in metabolic and reproductive functions. Leptin receptor has a soluble form that binds to leptin, thus modulating its level in the circulation. It has been indicated that the levels of leptin and leptin receptor and also LEP rs7799039 and LEPR rs1137101 polymorphisms are associated with metabolic disorders. In the present study, we assessed the levels of leptin and soluble leptin receptor (sOB-R), and also the frequency of rs7799039 and rs1137101 polymorphisms in healthy fertile women and patients with polycystic ovary syndrome (PCOS), inclusive of PCOS-infertile and PCOS-recurrent pregnancy loss (RPL) subjects.
A total of 324 PCOS patients- including 199 infertile cases and 125 patients with a history of RPL- and 144 healthy controls were enrolled in this study. Biochemical parameters and plasma leptin and sOB-R levels were measured by ELISA and the genotypes of rs7799039 and rs1137101 polymorphisms were determined using PCR- RFLP.
Plasma leptin and sOB-R levels were significantly higher and lower in PCOS, PCOS-infertile and PCOS RPL groups, respectively. The GG genotype frequencies of rs7799039 and rs1137101 polymorphisms were significantly different between PCOS-infertile women and non-PCOS subjects (P = 0.043, OR = 0.47, 95% CI = 0.22-0.97, and P = 0.01, OR = 0.31, 95% CI = 0.12-0.75, respectively). Increased LEP levels were associated with the risk of PCOS and RPL in women with PCOS (P = 0.039, OR = 1.203, 95%CI = [1.009-1.435] and P = 0.012, OR = 1.267, 95% CI = [1.054-1.522], respectively).
Polymorphisms rs7799039 and rs1137101 and circulating leptin and sOB-R levels were associated with infertility in Iranian women with PCOS. Further studies are needed to reveal the role of leptin in PCOS pathogenesis. |
| doi_str_mv | 10.1371/journal.pone.0255920 |
| format | Article |
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A total of 324 PCOS patients- including 199 infertile cases and 125 patients with a history of RPL- and 144 healthy controls were enrolled in this study. Biochemical parameters and plasma leptin and sOB-R levels were measured by ELISA and the genotypes of rs7799039 and rs1137101 polymorphisms were determined using PCR- RFLP.
Plasma leptin and sOB-R levels were significantly higher and lower in PCOS, PCOS-infertile and PCOS RPL groups, respectively. The GG genotype frequencies of rs7799039 and rs1137101 polymorphisms were significantly different between PCOS-infertile women and non-PCOS subjects (P = 0.043, OR = 0.47, 95% CI = 0.22-0.97, and P = 0.01, OR = 0.31, 95% CI = 0.12-0.75, respectively). Increased LEP levels were associated with the risk of PCOS and RPL in women with PCOS (P = 0.039, OR = 1.203, 95%CI = [1.009-1.435] and P = 0.012, OR = 1.267, 95% CI = [1.054-1.522], respectively).
Polymorphisms rs7799039 and rs1137101 and circulating leptin and sOB-R levels were associated with infertility in Iranian women with PCOS. Further studies are needed to reveal the role of leptin in PCOS pathogenesis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0255920</identifier><identifier>PMID: 34407095</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abortion ; Abortion, Habitual - blood ; Abortion, Habitual - genetics ; Adult ; Biology and Life Sciences ; Care and treatment ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Genotypes ; Health aspects ; Health risks ; Humans ; Infertility ; Infertility, Female - blood ; Infertility, Female - genetics ; Investigations ; Iran ; Leptin ; Leptin - blood ; Leptin - genetics ; Medicine and Health Sciences ; Metabolic disorders ; Obesity ; Pathogenesis ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - genetics ; Polymorphism, Single Nucleotide ; Pregnancy ; Pregnant women ; Receptors ; Receptors, Leptin - blood ; Receptors, Leptin - genetics ; Serum levels ; Stein-Leventhal syndrome</subject><ispartof>PloS one, 2021-08, Vol.16 (8), p.e0255920</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Kargasheh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Kargasheh et al 2021 Kargasheh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-9141703545c0a9ad5cb1640ce75f4055c00d451d7b3d5539df5ade59386ab5523</citedby><cites>FETCH-LOGICAL-c585t-9141703545c0a9ad5cb1640ce75f4055c00d451d7b3d5539df5ade59386ab5523</cites><orcidid>0000-0002-8202-7914</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372961/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372961/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34407095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kargasheh, Fatemeh Bagheri</creatorcontrib><creatorcontrib>Ansaripour, Soheila</creatorcontrib><creatorcontrib>Borumandnia, Nasrin</creatorcontrib><creatorcontrib>Moradi, Nariman</creatorcontrib><creatorcontrib>Zandieh, Zahra</creatorcontrib><creatorcontrib>Maleki, Monireh</creatorcontrib><creatorcontrib>Mokhtar, Sara</creatorcontrib><creatorcontrib>Karimi, Atousa</creatorcontrib><creatorcontrib>Fatemi, Farnaz</creatorcontrib><creatorcontrib>Kheirollahi, Asma</creatorcontrib><creatorcontrib>Vatannejad, Akram</creatorcontrib><title>Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Adipokine leptin plays a crucial role in metabolic and reproductive functions. Leptin receptor has a soluble form that binds to leptin, thus modulating its level in the circulation. It has been indicated that the levels of leptin and leptin receptor and also LEP rs7799039 and LEPR rs1137101 polymorphisms are associated with metabolic disorders. In the present study, we assessed the levels of leptin and soluble leptin receptor (sOB-R), and also the frequency of rs7799039 and rs1137101 polymorphisms in healthy fertile women and patients with polycystic ovary syndrome (PCOS), inclusive of PCOS-infertile and PCOS-recurrent pregnancy loss (RPL) subjects.
A total of 324 PCOS patients- including 199 infertile cases and 125 patients with a history of RPL- and 144 healthy controls were enrolled in this study. Biochemical parameters and plasma leptin and sOB-R levels were measured by ELISA and the genotypes of rs7799039 and rs1137101 polymorphisms were determined using PCR- RFLP.
Plasma leptin and sOB-R levels were significantly higher and lower in PCOS, PCOS-infertile and PCOS RPL groups, respectively. The GG genotype frequencies of rs7799039 and rs1137101 polymorphisms were significantly different between PCOS-infertile women and non-PCOS subjects (P = 0.043, OR = 0.47, 95% CI = 0.22-0.97, and P = 0.01, OR = 0.31, 95% CI = 0.12-0.75, respectively). Increased LEP levels were associated with the risk of PCOS and RPL in women with PCOS (P = 0.039, OR = 1.203, 95%CI = [1.009-1.435] and P = 0.012, OR = 1.267, 95% CI = [1.054-1.522], respectively).
Polymorphisms rs7799039 and rs1137101 and circulating leptin and sOB-R levels were associated with infertility in Iranian women with PCOS. Further studies are needed to reveal the role of leptin in PCOS pathogenesis.</description><subject>Abortion</subject><subject>Abortion, Habitual - blood</subject><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Infertility</subject><subject>Infertility, Female - blood</subject><subject>Infertility, Female - genetics</subject><subject>Investigations</subject><subject>Iran</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Leptin - genetics</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Pathogenesis</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Receptors</subject><subject>Receptors, Leptin - blood</subject><subject>Receptors, Leptin - genetics</subject><subject>Serum levels</subject><subject>Stein-Leventhal syndrome</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkt2K1DAUx4so7rr6BqIBQbyZMU1y-nEjDIuuAwui6HVI03QmQ5rUpJ2lj-bbmc50lhnxKuGc3_mfzyR5neJlSvP0484N3gqz7JxVS0wASoKfJNdpSckiI5g-PftfJS9C2GEMtMiy58kVZQznuITr5M8qBCe16LWzyDXIqK7XFt0RYMUKCVufLF7J-HEefSeE_kCdM2PrfLfVoQ0Hrt8q7VFQfmhjzF6ZgB50v0XaNsr32uh-PHBRaPBe2R51Xm2ssHJExoUQQbT2wmph0YNrlT2GT4nkGHotkdsLP6Iw2tpH_8vkWSNMUK_m9yb59eXzz9uvi_tvd-vb1f1CQgH9okxZmmMKDCQWpahBVmnGsFQ5NAxDtOKaQVrnFa0BaFk3IGoFZZyUqAAIvUneHnW7WCWfpx44gYwAZgXJIrE-ErUTO9553cY6uROaHwzOb7iIE5BGcSIkzuIaypwSVjVQVkQxqARrqkY1CketT3O2oWpVLeOcvDAXopceq7d84_a8oDkpszQKfJgFvPs9qNDzVgepjBFWueFYd0FJCkVE3_2D_r-7mdqI2EDcpot55STKV1lOWJ4DnrTen1FbJUy_Dc4M012FS5AdQenj0r1qHntLMZ8O-1QEnw6bz4cdw96cz-Ux6HTJ9C8nzviw</recordid><startdate>20210818</startdate><enddate>20210818</enddate><creator>Kargasheh, Fatemeh Bagheri</creator><creator>Ansaripour, Soheila</creator><creator>Borumandnia, Nasrin</creator><creator>Moradi, Nariman</creator><creator>Zandieh, Zahra</creator><creator>Maleki, Monireh</creator><creator>Mokhtar, Sara</creator><creator>Karimi, Atousa</creator><creator>Fatemi, Farnaz</creator><creator>Kheirollahi, Asma</creator><creator>Vatannejad, Akram</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8202-7914</orcidid></search><sort><creationdate>20210818</creationdate><title>Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome</title><author>Kargasheh, Fatemeh Bagheri ; Ansaripour, Soheila ; Borumandnia, Nasrin ; Moradi, Nariman ; Zandieh, Zahra ; Maleki, Monireh ; Mokhtar, Sara ; Karimi, Atousa ; Fatemi, Farnaz ; Kheirollahi, Asma ; Vatannejad, Akram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-9141703545c0a9ad5cb1640ce75f4055c00d451d7b3d5539df5ade59386ab5523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abortion</topic><topic>Abortion, Habitual - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kargasheh, Fatemeh Bagheri</au><au>Ansaripour, Soheila</au><au>Borumandnia, Nasrin</au><au>Moradi, Nariman</au><au>Zandieh, Zahra</au><au>Maleki, Monireh</au><au>Mokhtar, Sara</au><au>Karimi, Atousa</au><au>Fatemi, Farnaz</au><au>Kheirollahi, Asma</au><au>Vatannejad, Akram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-08-18</date><risdate>2021</risdate><volume>16</volume><issue>8</issue><spage>e0255920</spage><pages>e0255920-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Adipokine leptin plays a crucial role in metabolic and reproductive functions. Leptin receptor has a soluble form that binds to leptin, thus modulating its level in the circulation. It has been indicated that the levels of leptin and leptin receptor and also LEP rs7799039 and LEPR rs1137101 polymorphisms are associated with metabolic disorders. In the present study, we assessed the levels of leptin and soluble leptin receptor (sOB-R), and also the frequency of rs7799039 and rs1137101 polymorphisms in healthy fertile women and patients with polycystic ovary syndrome (PCOS), inclusive of PCOS-infertile and PCOS-recurrent pregnancy loss (RPL) subjects.
A total of 324 PCOS patients- including 199 infertile cases and 125 patients with a history of RPL- and 144 healthy controls were enrolled in this study. Biochemical parameters and plasma leptin and sOB-R levels were measured by ELISA and the genotypes of rs7799039 and rs1137101 polymorphisms were determined using PCR- RFLP.
Plasma leptin and sOB-R levels were significantly higher and lower in PCOS, PCOS-infertile and PCOS RPL groups, respectively. The GG genotype frequencies of rs7799039 and rs1137101 polymorphisms were significantly different between PCOS-infertile women and non-PCOS subjects (P = 0.043, OR = 0.47, 95% CI = 0.22-0.97, and P = 0.01, OR = 0.31, 95% CI = 0.12-0.75, respectively). Increased LEP levels were associated with the risk of PCOS and RPL in women with PCOS (P = 0.039, OR = 1.203, 95%CI = [1.009-1.435] and P = 0.012, OR = 1.267, 95% CI = [1.054-1.522], respectively).
Polymorphisms rs7799039 and rs1137101 and circulating leptin and sOB-R levels were associated with infertility in Iranian women with PCOS. Further studies are needed to reveal the role of leptin in PCOS pathogenesis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34407095</pmid><doi>10.1371/journal.pone.0255920</doi><orcidid>https://orcid.org/0000-0002-8202-7914</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-08, Vol.16 (8), p.e0255920 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2562504826 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abortion Abortion, Habitual - blood Abortion, Habitual - genetics Adult Biology and Life Sciences Care and treatment Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease Genotype Genotypes Health aspects Health risks Humans Infertility Infertility, Female - blood Infertility, Female - genetics Investigations Iran Leptin Leptin - blood Leptin - genetics Medicine and Health Sciences Metabolic disorders Obesity Pathogenesis Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - genetics Polymorphism, Single Nucleotide Pregnancy Pregnant women Receptors Receptors, Leptin - blood Receptors, Leptin - genetics Serum levels Stein-Leventhal syndrome |
| title | Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A54%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20leptin%20G2548A%20and%20leptin%20receptor%20Q223R%20polymorphisms%20and%20their%20serum%20levels%20with%20infertility%20and%20recurrent%20pregnancy%20loss%20in%20Iranian%20women%20with%20polycystic%20ovary%20syndrome&rft.jtitle=PloS%20one&rft.au=Kargasheh,%20Fatemeh%20Bagheri&rft.date=2021-08-18&rft.volume=16&rft.issue=8&rft.spage=e0255920&rft.pages=e0255920-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0255920&rft_dat=%3Cgale_plos_%3EA672477508%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2562504826&rft_id=info:pmid/34407095&rft_galeid=A672477508&rft_doaj_id=oai_doaj_org_article_2ac0605397324bf59b2e45ba4fbfefe0&rfr_iscdi=true |